Vishnu Suresh Babu

Accomplished Molecular Biology Researcher specializing in organelle communication, autophagy, and metabolic changes linked to aging. Expertise in CRISPR technology and cell line engineering, driving innovative models that enhance understanding of stress signaling and cellular senescence. Strong project management skills foster collaboration and propel advancements in cancer and metabolic research.

• A non-canonical AKT1-TERT pathway coordinates autophagy and ERphagy., Suresh Babu, V., Ghosh, S., Bammidi, S., Jiwon, R., Sharma, R., Meyer, D., Hose, S., Pattabiraman, P., Sahel, J., Kidley, N., Braz, N., Slater, M., Lang, S., Ghosh, A., Yi, J., Sripathi, S., Rangaramanujam, K., Bharti, K., & Sinha, D., Nature Communications, 2025, Manuscript under review, https://doi.org/10.1101/2025.11.24.690135
• STING activation induces polarized cytokine secretion of IFN-β and IL-17A, promoting photoreceptor death and choroidal disruption in age-related macular degeneration., Huang, C., Suresh Babu, V., Bammidi, S., Arnold, J. N., Ebeling, M., Widmer, G., Strassburger, P., Lazendic, M., Grüner, S., Koester, J., Dutta, P., Hose, S., Singh, S., Gautam, P., Lad, E. M., Westenskow, P. D., Kutsyr, O., Csaky, K. G., Ghosh, S., Sripathi, S. R., Proia, A. D., Flores-Bellver, M., Sinha, D., & Feenstra, D., Cell death and disease, 2025, accepted in principle; joint first author
• Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1- Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration., Chatterjee S, Ghosh S, Sin Z, Suresh Babu V, Preval LV, Davis E, Tran N, Bammidi S, Gautam P, Hose S, Sergeev Y, Flores-Bellver M, Ritter K, Jessen HJ, Al Diri I, Sinha D, Guha P., Aging Cell, 2025, 07/15/25, 40662679
• MLST8 overexpression in RPE cells disrupts autophagy through novel mechanisms affecting AMD pathogenesis., Bammidi S, Ghosh S, Chowdhury O, Suresh Babu, V., Dutta P, Hose S, Sinha D., Autophagy, 2025, 04/14/25, 40205682
• Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice., Chowdhury, O., Bammidi, S., Gautam, P., Suresh Babu, V., Liu, H., Shang, P., Xin, Y., Mahally, E., Nemani, M., Koontz, V., Lathrop, K., Kedziora, K. M., Franks, J., Sun, M., Smith, J. W., DeVine, L. R., Cole, R. N., Stepicheva, N., Strizhakova, A., Chattopadhyay, S., Sinha, D., Aging cell, 2025, 02/17/25, 39957408
• Depleted hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in retinoblastoma tumors., Suresh Babu V, Mallipatna A, Dudeja G, Shetty R, Nair AP, Tun SBB, Ho CEH, Chaurasia SS, Bhattacharya SS, Verma NK, Lakshminarayanan R, Guha N, Heymans S, Barathi VA, Ghosh A., Translational Research, 2023, 07/06/23, 37419277
• Enhanced Epithelial-to-Mesenchymal Transition and Chemoresistance in Advanced Retinoblastoma Tumors Is Driven by miR-181a., Suresh Babu V, Bisht A, Mallipatna A, Sa D, Dudeja G, Kannan R, Shetty R, Guha N, Heymans S, Ghosh A., Cancers (Basel), 2022, 10/19/22, 36291907, PMC9600213
• Lack of Retinoblastoma Protein Shifts Tumor Metabolism from Glycolysis to OXPHOS and Allows the Use of Alternate Fuels., Suresh Babu V, Dudeja G, Sa D, Bisht A, Shetty R, Heymans S, Guha N, Ghosh., Cells, 2022, 10/11/22, 36291051, PMC9600484
• Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors., Suresh Babu V, Mallipatna A, Sa D, Dudeja G, Kannan R, Shetty R, Nair AP, Gundimeda S, Chaurasia SS, Verma NK, Lakshminarayanan R, Heymans S, Barathi VA, Guha N, Ghosh A., Cells, 2022, 05/18/22, 35626705, PMC9139581
• Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial Dodecapeptides., Suresh Babu V, Kizhakeyil A, Dudeja G, Chaurasia SS, Barathi VA, Heymans S, Verma NK, Lakshminarayanan R, Ghosh A., Pharmaceutics, 2022, 11/18/22, 36432697, PMC9694048
• Retinoblastoma genetics screening and clinical management., Gupta H, Malaichamy S, Mallipatna A, Murugan S, Jeyabalan N, Suresh Babu V, Ghosh A, Ghosh A, Santhosh S, Seshagiri S, Ramprasad VL, Kumaramanickavel G., BMC Med Genomics, 2021, 07/22/21, 34294096, PMC8296631
• Type 1-type 2 interferon imbalance in dry eye disease., Panigrahi T, D'Souza S, Suresh Babu V, Dickman MM, Nuijts RMMA, Sethu S, Shetty R., Indian J Ophthalmol, 2023, 04/01/23, 37026295, PMC10276729
• Host factors related to SARS-CoV2 infection in the human eye and prophylaxis thereof., S. D’Souza, Suresh Babu V, T. Panigrahi, R. Shetty, P. Khamar, P. B, Sethu S, Ghosh., 2022, in press
• Integrated Transcriptomics and Metabolomics Study of Retinoblastoma Using Agilent Microarrays and LC / MS / GC / MS Platforms Application Note., N. Guha, S. Gundimeda, A. Padmanaban, A. Mallipatna, Suresh Babu V, Ghosh A., 2015, Agilent Technologies