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Vivek Mahadevan
Director, Integrated Bioanalysis
Frederick,MD
Summary
Seasoned molecular biologist and translational medicine lead with 14+ years of experience in bioanalysis across therapeutic modalities. Proven independent leader and scientific subject matter expert. Successfully drove neuroimmune and neuropsychiatric disorder drug discovery through multi-omic screening and computational approaches. Skilled in developing robust bioanalytical strategies, leading projects to candidate selection, and advancing portfolios. Demonstrated ability in talent development, portfolio oversight, and resource planning. Experienced in gene therapy design, antibody-drug conjugates, bioanalytical techniques for Pharmacokinetics, Cellular Kinetics (CK), Biodistribution, Immunogenicity, and Biomarkers. In-depth knowledge of fit-for-purpose assay validation / qualification in bioanalysis. Proven publication and presentation record. Exceptional verbal and written communication skills. Driven, detail-oriented, and dedicated to research excellence. Outstanding mentor.
Overview
17
17
years of professional experience
11
11
years of post-secondary education
2
2
Certifications
Work History
Director of Operations, Molecular Genomics Core
National Institutes of Health
04.2024 - Current
- Oversaw daily operations across 65+ NICHD labs, ensuring seamless coordination and efficient execution of sequencing experiments at the MGC.
- Provided technical leadership and execution of novel scRNAseq and spatial genomics workflows for NICHD labs.
- Defined, implemented, and revised operational policies and guidelines.
- Negotiated with vendors, suppliers and other stakeholders to acquire mutually beneficial contracts and agreement.
- Managed successful relocation of the facility to new campus without disruptions to existing operations.
- Mentored Staff Scientists, research fellows and graduate students.
- Coauthored 3 collaborative studies, and corresponded 1 manuscript.
Scientist, Neuro & Immunology
EMD Serono
10.2023 - 04.2024
- Single-cell disease atlas for discovery and identification of novel cell targets and molecular targets.
- Identify and evaluate novel targets for 4 distinct neuroimmune disorders.
- Established novel drug discovery screening for neuro-immune co-cultures
- Streamlined scRNAseq workflows for purifying infiltrating immune cells in CNS disorders.
Scientist, Gene Therapy
Patch Biosciences
09.2022 - 07.2023
- Assay Development: Developed, characterized and validated novel synthetic regulatory synthetic DNA elements through massively parallel reporter assays (MPRA), single-cell transcriptomics, Next generation sequencing (NGS) assays for AAV-based gene therapy
- Collaborate extensively with computational and machine learning team; Expert application in R and statistical programming to identify top synthetic regulatory elements and drive assay pipelines
- Conducted 25+ in vivo and in vitro MPRA screens; initiate in vivo brain gene therapy program; identify and validate novel therapeutics in (AAV8) liver and (AAV9) muscle gene therapy program; Investigated on-target / off-target delivery.
- Manage CRO partnerships; mentor junior scientists in designing & conducting experiments, including troubleshooting and development of disease-relevant assays
- Collaborate and communicate across diverse research team to successfully progress scientific goals
Senior Visiting Fellow
NIH, NICHD, Lab Of Dr. Chris McBain
02.2016 - 08.2022
- Assay development: Brain-specific biomarker screens for seizure disorder, schizophrenia, depression using single-cell transcriptomics, mRNA translatomics, proteomics and multi-omic analyses and identified novel high-risk candidates.
- Team leader in multi-institute NIH collaboration examining brain development and identifying novel biomarkers underlying schizophrenia and depression using pre-clinical transgenic mouse models. Employed multifaceted unbiased screening platform involving FACS, 10X Genomics microfluidics platform, library preparation, NGS.
- Team contributor in 3 additional projects investigating molecular underpinnings in intellectual disability, autism, Lissencephaly by employing NGS approaches.
- Employed range of assays using cell biological, electrophysiological, molecular genetics, biochemistry, histology of tissue sections, RNAscope, IHC, high-content imaging, immunoassays, cellular pharmacological approaches (PK-PD), and mouse behavioral assays for preclinical validation of lead molecules.
- Extensive mouse behavioral phenotyping through writing and amending IACUC protocols.
- Effective in working with and managing high-functioning teams. Collaborated with computational biologists and bioinformaticians to generate integrated atlas single-cell of rodent and primate brain generated across 4 international research institutes.
- Effectively communicate results to project teams and senior scientists and management to facilitate decision making.
- Invited for research talks to present findings at international conferences, and across Universities in US, Canada and India.
- Leveraged interpersonal and communication skills to mentor technicians, graduate students and post-baccalaureate trainees, and enabled them to complete short-term projects.
- Published 2 first-authored, 4 co-authored research articles, 2 first-authored manuscripts under preparation. Peer-reviewed 70+ manuscripts and submitted 3 grants to research foundations.
Postdoctoral Scientist
University Of Toronto, Lab Of Prof. Melanie Woodin
08.2015 - 01.2016
- Assay development: Brain-specific biomarker screens for Huntington's and CNS degenerative disorders, seizure disorders and autism, using proteomics to identify novel high-risk candidates.
- Team leader in conducting neuron-specific proteomics, cell biology discovery pipelines to study ion channel-transporter complexes and biomarkers involved in seizure, psychiatric and
neurodegeneration disorders using pre-clinical mouse models. - Identified, characterized novel pathways involved in Epilepsy, Autism and Huntington's degeneration through behavior, primary cell cultures, biochemistry, electrophysiology, cell biology. and mouse
behavioral phenotyping. - Collaborated with 3 multidisciplinary teams across North America, Europe, Australia.
- Mentored technicians, PhD, graduate and undergraduate students.
- Published 2 first-authored, 2 co-authored research articles, 2 review articles and 3 book chapters.
Graduate Research & Teaching Assistant
University Of Toronto, Lab Of Prof. Melanie Woodin
09.2011 - 07.2015
- Assay development - Brain-specific biomarker screens for epilepsy and neuropathic pain using interactome proteomics to identify novel high-risk candidates.
- Team leader in 3 main projects characterizing novel biomarkers for nervous system ion channels and transporter functions aberrant in neurological disorders.
- Team contributor in 4 additional projects in schizophrenia, memory formation. Extensively performed CNS-targeted injections of AAVs and investigate psychosis-like behavior.
- Independently designed and executed experiments and provided comprehensive research assistance to collaborative projects. Recorded data and maintained source documentation following good documentation practices.
- Published 2 first-authored, 3 co-authored research articles.
Neurophysiologist, Research Technologist
University Of Toronto, Lab Of Prof. John Roder
03.2010 - 08.2011
- Established in vitro assays using primary neuronal cultures, cell lines to study membrane protein dynamics via biochemistry, molecular biology, neurophysiology and imaging.
- Generated novel hypothesis and critical datasets to successfully steer complex and long-pending projects.
- Published 1 first-authored, 2 co-authored research articles.
Graduate Research Assistant
University Of Toronto, Lab Of Prof. Rod McInnes
01.2008 - 01.2010
- Established, Membrane protein pull-down and MYTH interaction assays.
- Identified 30+ regulators of synaptic transmission and validated 3 to completion.
- Published 1 co-authored research article.
Education
PhD - Biochemistry, Neuroscience, Cell & Systems Biology
University of Toronto, Dept. Cell & Systems Biol.
Toronto, Canada 09.2011 - 07.2015
Master of Science - Molecular Genetics
University of Toronto, Dept. Molecular Genetics
Toronto, Canada 01.2008 - 01.2010
Master of Science - Advanced Biochemistry
University of Madras, Dept. Advanced Biochemistry
Chennai, India 07.2004 - 07.2006
Bachelor of Science - Biochemistry
University of Madras, Dept. Biochemistry
D.G. Vaishnav College, Chennai, India 06.2000 - 12.2003
Skills
Lead scientists, program development, detail oriented with excellent organizational skills
Preclinical in vivo models of complex disorders, dosing, PK/PD, biodistribution and bioavailability
Foundational and translational biology, hypothesis generation, study design, analysis and publication
Identify and establish collaborations, critically evaluation of scientific assay data quality and results
Demonstrated ability to troubleshoot complex problems, work effectively in multi-disciplinary teams
Biomarker identification using NGS, Cell-type specific, single-cell and spatial transcriptomics
Effectively collaborate with stakeholders, providing effective solutions to challenges and risk-mitigation
Strategic planning and execution, process improvement, operations efficiency and oversight, resource allocation
Accomplishments
- Published 25 - first-authored, co-authored peer-reviewed publications and invited book chapters, in well accredited scientific platforms including eLife, Cell Reports, Journal of Neuroscience, Journal of Physiology, Neuron, PNAS and Elsevier Publications.
- Presented work at 15+ international conferences and 10 invited talks including at the Gordon Research Conference, ASPET, National Institutes of Aging, Indian Institute of Science, Indian Institute of Technology-M,K.
- PhD. research findings directly resulted in (CAD$) 500,000+ research funding.
- Recipient of 12 national and international competitive research awards.
- Mentored10+ undergraduate, graduate students and conducted science outreach activities.
- Peer-reviewed 70+ manuscripts for 10 international scientific journals.
Certification
Advanced Training Certification in Proteomics Bioinformatics, by EMBL-EBI and Wellcome Trust, UK
Software
References
Available upon request.
Timeline
Director of Operations, Molecular Genomics Core
National Institutes of Health
04.2024 - Current
Scientist, Neuro & Immunology
EMD Serono
10.2023 - 04.2024
Scientist, Gene Therapy
Patch Biosciences
09.2022 - 07.2023
Bioinformatic Analysis of NGS Data, by The Foundation for Advanced Education in the Sciences, NIH
04-2017
Senior Visiting Fellow
NIH, NICHD, Lab Of Dr. Chris McBain
02.2016 - 08.2022
Postdoctoral Scientist
University Of Toronto, Lab Of Prof. Melanie Woodin
08.2015 - 01.2016
Advanced Training Certification in Proteomics Bioinformatics, by EMBL-EBI and Wellcome Trust, UK
11-2014
Graduate Research & Teaching Assistant
University Of Toronto, Lab Of Prof. Melanie Woodin
09.2011 - 07.2015
PhD - Biochemistry, Neuroscience, Cell & Systems Biology
University of Toronto, Dept. Cell & Systems Biol.
09.2011 - 07.2015
Neurophysiologist, Research Technologist
University Of Toronto, Lab Of Prof. John Roder
03.2010 - 08.2011
Graduate Research Assistant
University Of Toronto, Lab Of Prof. Rod McInnes
01.2008 - 01.2010
Master of Science - Molecular Genetics
University of Toronto, Dept. Molecular Genetics
01.2008 - 01.2010
Master of Science - Advanced Biochemistry
University of Madras, Dept. Advanced Biochemistry
07.2004 - 07.2006
Bachelor of Science - Biochemistry
University of Madras, Dept. Biochemistry
06.2000 - 12.2003
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