Intern
Boehringer Ingelheim Pharmaceuticals
06.2023 - 08.2023
- IVIVC, DDI risk calculation
- Co-med list development
- Transporter activity prediction
Xin Chen
Seattle,WA
Summary
- Ji-Ping Wang Endowed Fellowship 2022
- Excellent Graduate 2019
- Merit Student 2016 & 2017
Work History
Education
Ph.D. - Pharmaceutics
University of Washington
Seattle, WA06.2024
Bachelor of Science - Pharmacy (Basic Pharmacy)
China Pharmaceutical University
Nanjing, China06.2019
Skills
- DMPK research (Transwell/vesicles/microsome etc)
- Modeling (Phoenix/Symcyp/R)
- LC-MS/MS quantification and method development, proteomics
- Animal research techniques (administration, tissue harvest)
selected publications
- Chen X, Unadkat JD, and Mao Q (2023) Maternal and Fetal Exposure to (-)-Δ9-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Drug Metab Dispos 51(3):269-275
- Mao Q and Chen X (2022) An update on placental drug transport and its relevance to fetal drug exposure. Medical Review 2(5): 501-511
- Chen X, Unadkat JD, and Mao Q (2021) Tetrahydrocannabinol and its major metabolites are not (or are poor) substrates or inhibitors of human P-Glycoprotein [ATP-binding cassette (ABC) B1] and breast cancer resistance protein (ABCG2). Drug Metab Dispos 49:910–918
- Li J, Lu Y, Wang D, Quan F, Chen X et al. (2019) Schisandrin B prevents ulcerative colitis and colitis-associated-cancer by activating focal adhesion kinase and influence on gut microbiota in an in vivo and in vitro model. Eur J Pharmacol 854:9–21
- Wang D, Li X, Li Jiani, Lu Y, Zhao S, Tang X, Chen X et al. (2019) APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression. Gut 68:1846–1857
- Chen X et al. (2018) Quorum sensing inhibitors: a patent review (2014–2018). Expert Opin Ther Pat, 28:849–865
Timeline
Intern
Boehringer Ingelheim Pharmaceuticals
06.2023 - 08.2023
Ph.D. - Pharmaceutics
University of Washington
Bachelor of Science - Pharmacy (Basic Pharmacy)
China Pharmaceutical University
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