Yi Chen

Personal Profile Name: Yi Chen M.D., M.Sc., Ph.D. Gender: Male Date of Birth: 06/10/1992 Working Address: Columbia Stem Cell Initiative, Department of Medicine, Division of Hematology & Oncology, Columbia University Irving Medical Center, 650 W. 168th Street, William Black Building, New York, NY 10032, United States Telephone: +1 9179514767 +86 15067753891 E-mail: chenyi.med@gmail.com; yc4229@cumc.columbia.edu

• 2022-2023, Researcher, Aaron Viny/Rual Rabadan group, Department of Medicine, Division of Hematology & Oncology, Columbia University Irving Medical Center, New York, NY, USA, Understanding the role of altered chromatin architecture as a regulator of gene expression
• 2021-2022, Researcher, Janne Lehtiö’s Group, Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden, Identification of candidates for therapy de-escalation in early HER2-positive breast cancer
• 2017-2021, Researcher, Olle Larsson's Group, Bioclinicum, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden, Investigating the transcriptome profiling of Ewing sarcomas
• 2015-2016, Resident, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China, Clinical practice in the Department of Urology
• 2014-2017, Researcher, Central Laboratory of Basic Medical Science, Guilin Medical University, Guilin, Guangxi, China, Investigating the biological functions of long non-coding RNAs in bladder cancer
• 2013-2014, Intern, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China, Clinical rotations in the Department of General Medicine

• 2024, Poster presentation at Fourteenth International Myeloid Workshop, Cincinnati, USA
• 2023, Presentations at FASEB Hematological Malignancies Conference, Worcester, USA
• 2022, Excellent Ph.D., Karolinska Institute, Sweden
• 2021, Poster presentation in Translational Immunology meeting, Ghent, Belgium
• 2020, Presentation in American Association for Cancer Research (AACR) annual meeting, San Diego, CA (Online)
• 2017, Excellent postgraduate scholarship
• 2016, First class scholarship
• 2015, Postgraduate student innovation project, No: YCSZ2015215 (CNY 30,000)
• 2012, Hospital outstanding student union officer
• 2011, Excellent individual in a social field trip of undergraduate student
• 2011, First place in the English speech contest

• Frontiers in Immunology
• Frontiers in Oncology
• Scientific Reports
• Cell Biochemistry and Biophysics
• Molecular Cytogenetics
• Discover Oncology
• BMC Cancer
• BMC Medical Informatics and Decision Making

650 W. 168th Street, William Black Building, New York, NY, 10032, United States

• Date of Birth: 06/10/92
• Gender: Male

• Mandarin
• English

• Molecular Profiling Defines Three Subtypes of Synovial Sarcoma, Y. Chen
• Y. Su, X. Cao, I. Siavelis, I. R. Leo, J. Zeng, P. Tsagkozis, A. C. Hesla, A. Papakonstantinou, X. Liu, W.-K. Huang, B. Zhao, C. Haglund, M. Ehnman, H. Johansson, Y. Lin, J. Lehtiö, Y. Zhang, O. Larsson, X. Li, F. H. de Flon, Adv. Sci., 2024, https://doi.org/10.1002/advs.202404510
• Synergy of Stag2-Cohesin Loss Results in Expansion of Npm1c-Mutant Hematopoietic Stem and Progenitor Cells, Jane J Xu#, Yi Chen#, John Pantazi, Sebastian Fernando, Besmira Alija, Varun Sudunagunta, Govind Bhagat, Aaron D Viny, Blood, 2023-11-28, 142, 954
• Stag2-Cohesin Loss Attenuates Flt3 ITD Myeloid Blast Expansion Yet Preserves Mutant HSC, Jane J Xu#, Yi Chen#, John Pantazi, Sebastian Fernando, Besmira Alija, Varun Sudunagunta, Govind Bhagat, Robert L Bowman, Aaron D Viny, Blood, 2023-11-28, 142, 2756
• Transcriptome profiling of Ewing sarcomas - treatment resistance pathways and IGF-dependency, Chen Y, Hesla AC, Lin Y, Ghaderi M, Liu M, Yang C, Zhang Y, Tsagkozis P, Larsson O, Haglund F, Molecular Oncology, 2020, 14, 5, 1101-1117
• Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma, Chen Y
• Su H, Su Y, Zhang Y, Lin Y, Haglund F, Cancers, 2021, 13, 15, 3736
• TERT promoter mutation is an objective clinical marker for disease progression in chondrosarcoma, Zhang Y#, Chen Y#, Yang C, Seger N, Hesla AC, Tsagkois P, Larsson O, Lin Y, Haglund F, Modern Pathology, 2021, 34, 11, 2020-2027
• Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification, Chen Y
• You S, Li J, Zhang Y, Kokaraki G, Epstein E, Carlson J, Huang W-K, Haglund F, Frontiers in Immunology, 2021, 12, 788959
• Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification, Chen Y, Chen D, Wang Q, Xu Y, Huang X, Haglund F, Su H, Frontiers in Immunology, 2021, 12, 719105
• Integrated Analysis of Copy Number Variation, Microsatellite Instability, and Tumor Mutation Burden Identifies an 11-Gene Signature Predicting Survival in Breast Cancer, Jin X, Yan J, Chen C, Chen Y
• Huang W-K, Frontiers in Cell and Developmental Biology, 2021, 9, 721505
• Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer, Huang X, Chen C, Xu Y, Shen L, Chen Y
• Su H, Bioengineered, 2021, 12, 1, 2688-701
• Identification and Mechanism of the PD-1/PD-L1 Genomic Signature SORL1 as Protective Factor in Bladder Cancer, Xu Y, Chen D, Shen L, Huang X, Chen Y
• Su H, Frontiers in Genetics, 2021, 12, 736158
• LncROR promotes bladder cancer cell proliferation, migration, and epithelial-mesenchymal transition, Chen Y, Peng Y, Xu Z, Ge B, Xiang X, Zhang T, Gao L, Shi H, Wang C, Huang J, Cellular Physiology and Biochemistry, 2017, 41, 6, 2399-2410
• Knockdown of lncRNA SNHG7 inhibited cell proliferation and migration in bladder cancer through activating Wnt/β-catenin pathway, Chen Y, Peng Y, Xu Z, Ge B, Xiang X, Zhang T, Gao L, Shi H, Wang C, Huang J, Pathology-Research and Practice, 2019, 215, 2, 302-7
• Utility of Fluorescence In Situ Hybridization (FISH) to Sub-Classify Low-Grade Urothelial Carcinoma for Prognostication, Chen Y, Tao B, Peng Y, Yang W, Wang C, Xiang X, Zhang T, Gao L, Yi J, Zhou X, Huang J, Medical Science Monitor, 2017, 23, 3161-3167

• Cancer Biology
• Computational Biology
• Clinical Oncology
• Experimental Oncology
• Molecular Oncology
• Tumor Evolution
• Tumor Biomarkers
• Cancer Immunology
• Surgery
• Epidemiology
• Pathology
• RT-PCR
• QPCR
• Western Blot
• Co-IP
• Cell Culture
• Cell Functional Experiments
• Plasmid Vector Design and Construction
• Flow Cytometry
• Immunofluorescence
• Immunohistochemistry
• Mouse Experiments
• Liquid Chromatography Mass Spectrometry (LC-MS)
• Other Regular Biomolecular Techniques

• AI
• Deep Learning
• Machine Learning
• Data Science
• Neural Networks
• Programming
• Cloud Computing
• Image Recognition
• Python
• Tensorflow
• R programming
• SQL
• MATLAB
• TensorFlow
• PyTorch
• Keras
• Theano
• Amazon AWS
• Hypothesis Testing
• Tunning
• Algorithm Optimization
• Model Evaluation
• Bioinformatics
• Biostatistics
• Computer Graphics
• Multi-Omics