YONMEE HAN
San Jose,CA
Summary
Detail-oriented individual with exceptional communication and project management skills. Proven ability to handle multiple tasks effectively and efficiently in fast-paced environments. Recognized for taking proactive approach to identifying and addressing issues, with focus on optimizing processes and supporting team objectives.
Overview
28
28
years of professional experience
Work History
Sr. Scientist
Illumina, Inc.
11.2023 - 04.2025
- Perform automated and manual NGS library preparation of commercially released and in-development Library Prep Protocols
- Communicate with internal customers, including managing of larger long-term projects
- Perform data analysis and maintain accurate documentation of results, assist in troubleshooting and error tracking
- Assist with lab maintenance and inventory management
- Assess information to ensure data sufficiency and completeness of results
- Interface with various departments
- Contribute to the overall success of the project; anticipate problems to minimize issues and work to resolve any issues to minimize impact on success of project
- Use standard laboratory instrumentation: i.e. Covaris ultrasonicators, Bioanalyzer, TapeStation, Fragment Analyzer, qPCR machines, fluorescence plate readers, thermocyclers, liquid handling robotics
- General administrative duties
Associate Scientist 1
Illumina, Inc.
03.2022 - 11.2023
- Perform automated and manual NGS library preparation of commercially released and in-development Library Prep Protocols
- Communicate with internal customers, including managing of larger long-term projects
- Perform data analysis and maintain accurate documentation of results, assist in troubleshooting and error tracking
- Assist with lab maintenance and inventory management
- Assess information to ensure data sufficiency and completeness of results
- Interface with various departments
- Contribute to the overall success of the project; anticipate problems to minimize issues and work to resolve any issues to minimize impact on success of project
- Use standard laboratory instrumentation: i.e. Covaris ultrasonicators, Bioanalyzer, TapeStation, Fragment Analyzer, qPCR machines, fluorescence plate readers, thermocyclers, liquid handling robotics
- General administrative duties
Senior Clinical Laboratory Technician
PetDx
06.2021 - 03.2022
- Assist with routine and production-scale nucleic acid extraction and NGS library preparation for DNA/RNA sequencing using manual and automated methods
- Perform quality control and quality assurance procedures, track and manage data within LIMS and other IT application systems
- Monitor and maintain inventory, supplies, and organize materials
- Perform daily maintenance and decontamination of general laboratory and equipment
- Support Quality initiatives through good documentation practices, risk assessments, and root cause analysis for non-conforming events
- Participate or assist with a variety of other essential laboratory activities, including reagent qualification, inventory management, procedure writing, preventive maintenance, inspection preparation, assay validation, and troubleshooting investigations
Associate Scientist, Product Development
Verogen, Inc.
02.2018 - 06.2021
- Participate in developing products and assays for NGS applications from concept to commercialization
- Conduct laboratory work with minimal direction of supervisor
- Recognize potential problems, understand and troubleshoot assays
- Plan, conduct, analyze, interpret, and report recommendations based on tested experimental results
- Assess information to ensure data sufficiency and completeness of results.
- Write experimental reports, summaries and protocols for supervisors, project leads, and other teams as appropriate
- Contribute to the overall success of the project; anticipate problems to minimize issues and work to resolve any issues to minimize impact on success of project
- Contribute to planning of future experiments based on data analysis and input from team members
- Assist junior scientific staff in the laboratory with experiments, instrument training, and troubleshooting
- Sequence libraries on MiSeq, NextSeq and iSeq sequencers
- Run Infinium Assay workflow and scan Global Screening Array-24 BeadChip on iScan
- Order laboratory supply and chemicals as needed and prepare solutions and standards per written procedures
Associate Scientist 2
Illumina, Inc.
04.2015 - 02.2018
- Perform research and/or development activities, in collaboration with others, on complex company projects for DNA, RNA, cfDNA and FFPE samples.
- Make detailed observations, analyze data, interpret results and make recommendations to supervisors
- Write and present experimental reports, summaries and protocols for supervisors and other team members as appropriate.
- DNA purification from plasma using Qiagen kits
- Sequence libraries on MiSeq, HiSeq, NextSeq and NovaSeq sequencers
- Order laboratory supply and chemicals as needed and prepare solutions and standards per written procedures
Sr Research Associate
Illumina, Inc.
08.2012 - 04.2015
- Perform research and/or development activities, in collaboration with others, on complex company projects for DNA, RNA, cfDNA and FFPE samples.
- Make detailed observations, analyze data, interpret results and make recommendations to supervisors
- Write and present experimental reports, summaries and protocols for supervisors and other team members as appropriate.
- DNA purification from plasma using Qiagen kits
- Sequence libraries on MiSeq, HiSeq, NextSeq and NovaSeq sequencers
- Order laboratory supply and chemicals as needed and prepare solutions and standards per written procedures
Sr Quality Control Associate
Illumina, Inc.
11.2011 - 08.2012
- Validate QC protocol of new products to ensure a smooth transition from development to production QC
- Train QC personnel on new QC processes
- Write and revise Standard Operating Procedures and other QC documentation
- Assist in performing functional QC testing of Illumina library preparation reagents
Quality Control Analyst 2
Illumina, Inc.
07.2009 - 11.2011
- Perform functional QC testing of Illumina library preparation reagents as required in compliance with company specifications
- Analyze and review data from functional testing for compliance to specifications
- Report and determine causes of abnormalities in QC data
- Ensure that appropriate methodology is utilized without unauthorized modifications
- Write and revise Standard Operating Procedures and other QC documentation
- Assist in the development and validation of QC methods
- Order laboratory supply and chemicals as needed and prepare solutions and standards per written procedures
- Maintain chemicals and samples inventory
- Manage test samples, reagents and reference standards used for QC testing
- Train personnel on quality control methods and procedures
Manufacturing, Quality Control Associate 2
Illumina, Inc.
07.2007 - 07.2009
- Calibrate and test next generation DNA sequencing instrumentation such as the Genome Analyzer 2 and Genome Analyzer 3 using standard protocols
- Set up and operate test equipment, prepare DNA samples on Illumina Cluster Station and sequence DNA on Genome Analyzer 2 and Genome Analyzer 3
- Troubleshoot and resolve problems with the manufacturing team
- Analyze data to determine trends
- Establish and maintain logs and databases of instrument failures and defects
- Develop and edit Standard Operating Procedures for release testing on Genome Analyzers
- Train new members of the team
Biological Science Technician-Plants
United States Department of Agriculture-Agricultural Research Service
06.2004 - 06.2006
- Perform a variety of technical duties pertaining to the isolation and characterization of genetic markers and genes of interest using biotechnology methods including isolation of nucleic acids from plant, bacterial and fungal material, DNA quantification, and gel electrophoresis
- Perform PCR amplification and cycle sequencing of DNA molecules using ABI Prism 3100 Avant Genetic Analyzer
- Use Ploidy Analyzer to determine relative DNA content of various plants
- Analyze DNA sequences or fragments using bioinformatics software such as ABI Prism Sequencing Analysis 5.1, ABI Prism GeneMapper 3.7, Sequencher 4.5, Primer Select, MegAlign, Oligo 4.0, MapDraw and EditSeq
- Maintain, calibrate and modify laboratory equipment such as ABI Prism 3100 Avant Genetic Analyzer, MJ Research PTC-225 Peltier Thermal Cycler, Eppendorf Centrifuge 5810R, DNA110 SpeedVac, Barnstead Turner Quantech Fluorometer, NanoDrop Spectrophotometer and Partec Ploidy Analyzer
- Tabulate, statistically analyze and summarize data using personal computers and software packages for posters, presentations and publications
- Maintain lab stocks, keep inventories of lab stocks and submitted requests for supplies as needed
DNA Analysis Supervisor
Sequetech Corporation
11.1996 - 03.2003
- Monitor daily operations to ensure technical and performance based goals and objectives are met
- Collaborate with clients to design specific sequencing strategies
- Initiate and track sequencing projects
- Assemble final data packages for customers
- Perform cycle sequencing on DNA samples using BigDye Terminator or BigDye Primer methodologies on ABI Prism 377 DNA sequencers
- Maintain and troubleshoot lab equipment including three ABI Prism 377 DNA sequencers
Education
Bachelor of Arts - Biology
New York University
New York, NY05.1996
Associates Degree - undefined
De Anza College
Cupertino, CA08.1994
Skills
- Microscopy expertise
- Training and mentoring
- Scientific writing
- Safety processes and procedures
- Project management
- Research and experiments
- Assay development
- Lab experiments and research
- Laboratory techniques
- Laboratory equipment functions
- Experiment protocol development
- Teamwork
- Time management
- Multitasking
- Reliability
- Planning and scheduling
- Organizational skills
- Effective communication
- Self-driven and motivated
- Task prioritization
- Quality control testing
- Equipment maintenance
- Molecular biology
Accomplishments
Illumina TruSight Oncology 500 kit, Verogen ForenSeq Signature kit, Verogen ForenSeq Kintelligence kit
Timeline
Sr. Scientist
Illumina, Inc.
11.2023 - 04.2025
Associate Scientist 1
Illumina, Inc.
03.2022 - 11.2023
Senior Clinical Laboratory Technician
PetDx
06.2021 - 03.2022
Associate Scientist, Product Development
Verogen, Inc.
02.2018 - 06.2021
Associate Scientist 2
Illumina, Inc.
04.2015 - 02.2018
Sr Research Associate
Illumina, Inc.
08.2012 - 04.2015
Sr Quality Control Associate
Illumina, Inc.
11.2011 - 08.2012
Quality Control Analyst 2
Illumina, Inc.
07.2009 - 11.2011
Manufacturing, Quality Control Associate 2
Illumina, Inc.
07.2007 - 07.2009
Biological Science Technician-Plants
United States Department of Agriculture-Agricultural Research Service
06.2004 - 06.2006
DNA Analysis Supervisor
Sequetech Corporation
11.1996 - 03.2003
Associates Degree - undefined
De Anza College
Bachelor of Arts - Biology
New York University
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