Yun Zhu

Resourceful chemistry Ph.D. Candidate passionate about the investigation of biological macromolecules and their stability and regulation using native mass spectrometry. Adept in mass spec analysis, data analysis, experiment planning and problem solving.

First/Co-first

• Schrecke S, Zhu Y, McCabe JW, Bartz M, Packianathan C, Zhao M, Zhou M, Russell D, Laganowsky A. Selective regulation of human TRAAK channels by biologically active phospholipids. Nature Chemical Biology. 2021 Jan;17(1):89-95. DOI: 10.1038/s41589-020-00659-5. (Co-First)
• Yun Zhu, Samantha Schrecke, Shuli Tang, Melanie T. Odenkirk, Thomas Walker, Lauren Stover, Jixing Lyu, Tianqi Zhang, David Russell, Erin S. Baker, Xin Yan, and Arthur Laganowsky. Cupric Ions Selectively Modulate TRAAK–Phosphatidylserine Interactions. Journal of the American Chemical Society 2022 144 (16), 7048-7053. DOI: 10.1021/jacs.2c00612
• Yun Zhu, Bo-Ji Peng, Smriti Kumar, Lauren Stover, Jixing Lyu, Tianqi Zhang, Samantha Schrecke, David H. Russell, Lei Fang, Arthur Laganowsky. Polyamine detergents tailored for native mass spectrometry studies of membrane proteins. (Submitted and under review for Angewandte Chemie ) (Co-First)

Collaboration:

• Qiao P, Schrecke S, Walker T, McCabe JW, Lyu J, Zhu Y, Zhang T, Kumar S, Clemmer D, Russell DH, Laganowsky A. Entropy in the Molecular Recognition of Membrane Protein-Lipid Interactions. J Phys Chem Lett. 2021 Dec 30;12(51):12218-12224. DOI: 10.1021/acs.jpclett.1c03750.
• Qiao P, Schrecke S, Lyu J, Zhu Y, Zhang T, Benavides A, Laganowsky A. Insight into the Phospholipid-Binding Preferences of Kir3.4. Biochemistry. 2021 Dec 21;60(50):3813- 3821. DOI: 10.1021/acs.biochem
• Smriti Kumar, Yun Zhu, Lauren Stover, and Arthur Laganowsky. Step toward Probing the Nonannular Belt of Membrane Proteins. Anal. Chem. DOI: 10.1021/acs.analchem.2c02811
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