Yunyun Wang

To achieve a challenging and responsible position at Research & Development in Pharmaceutical Industry that fosters creativity and innovation through trust, flexibility, and freedom to work towards organizational goals for a Quality Products.

• Yining Jiang, Yunyun Wang, Liyan Zhao, Wenzhuo Yang, Lin Pan, Yang Bai, Yubo Wang & Yunqian Li, P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism, Discover Oncology, 2024, 15, 6
• Jianmin Wang, Jiashun Mao, Meng Wang, Xiangyang Le, Yunyun Wang
• Explore drug-like space with deep generative models, Methods, 2023, 210, 52-59
• Jiashun Mao
• Jianmin Wang, Amir Zeb, Kwang-Hwi Cho, Kwang-Hwi Cho, Haiyan Jin, Jongwan Kim, Onju Lee, Yunyun Wang
• and Kyoung Tai No
• Transformer Based Molecular Generative Model for Antiviral Drug Design, J. Chem. Inf. Model., 2023, https://doi.org/10.1021/acs.jcim.3c00536
• Zhongyuan Xu, Jjianqiang Qian, Chi Meng, Yun Liu, Hongmei Wu, Fansheng Ran, Gongqing Liu, Yunyun Wang
• Yong Ling
• TME-targeting theranostic agent uses NIR tracking for tumor diagnosis and surgical resection and acts as chemotherapeutic showing enhanced efficiency and minimal toxicity, Theranostics, 2022, 12, 6, 2535-2548
• Yunyun Wang, Wei Shi, Yuxun Zhao, Chenglong Zhang, Lin Wan, Chenliang Wu, Wen Gu, Shifa Wang
• Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism, Biomedicine & Pharmacotherapy, 2021, 139, 111663
• Yunyun Wang, Zhonglong Wang, Hongbo Kuang, Yan Zhang, Wen Gu, Yongqiang Zhu, Shifa Wang, Synthesis and antitumor activity of 2-isocamphanyl thiosemicarbazone derivatives via ROS-enhanced mitochondria damage, Chemical Biology & Drug Design, 2019, 94, 1, 1281-1291
• Yunyun Wang, Qiangjian Zhang, Chenliang Wu, Wen Gu, Yu Shan, Shifa Wang
• Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway, Bioorganic Chemistry, 2019, 84, 468-477
• Yunyun Wang, Wen Gu, Yu Shan, Fei Liu, Xu Xu, Yiqin Yang, Qiangjian Zhang, Yan Zhang, Hongbo Kuang, Zhonglong Wang, Shifa Wang
• Design, synthesis and anticancer activity of novel nopinone-based thiosemicarbazone derivatives, Bioorganic & Medicinal Chemistry Letters, 2017, 27, 11, 2360-2363
• Mingguang Zhang, Yunyun Wang, Shifa Wang, Hongyan Wu, Synthesis and Biological Evaluation of Novel Pyrimidine Amine Derivatives Bearing Bicyclic Monoterpene Moieties, Molecules, 2022, 27, 22, 8104
• Yang Yang, Yunyun Wang, Zhijie Zhang, Shifa Wang
• Zhen Li
• WSF-CT-11, a Sesquiterpene Derivative, Activates AMP-Activated Protein Kinase with Anti-diabetic Effects in 3T3-L1 Adipocytes, ACS Omega, 2021, 6, 31272–31281
• Chong-Hui Ma, Yunyun Wang, Fu-Hao Dong, Zhong-Long Wang, Shi-Fa Wang, Synthesis and antitumor activity of isolongifoleno[7,8-d]thiazolo[3,2-a]pyrimidine derivatives via enhancing ROS level, Chemical Biology & Drug Design, 2019, 94, 1, 1457-1466
• Yan Zhang, Yunyun Wang, Yu-Xun Zhao, Wen Gu, Shi-Fa Wang, Novel camphor-based pyrimidine derivatives induced cancer cell death through a ROS-mediated mitochondrial apoptosis pathway, RSC Advances, 2019, 9, 51, 29711-29720
• Qiang-Jian Zhang, Yunyun Wang, Shi-Fa Wang, Synthesis and a-Amylase Inhibitory Potential and Molecular Docking Study of Nopinone-Based Thiazolylhydrazine Derivatives, Chinese Journal of Organic Chemistry, 2019, 39, 5, 1372-1382
• Chen-Liang Wu, Yunyun Wang, Shi-Fa Wang, Synthesis and Antiproliferative Activity of Isolongifolanone Pyrazoline Derivatives Inducing Intracellular Rosl Accumulation, Pharmaceutical Chemistry Journal, 2019, 53, 2, 706-712
• Yudian Zhang, Yunyun Wang, Xiao-Chuan Li, Shi-Fa Wang, Zhen Li, WSF-7 Inhibits Obesity-Mediated PPARy Phosphorylation and Improves Insulin Sensitivity in 3T3-L1 Adipocytes, Biological & Pharmaceutical Bulletin, 2020, 43, 3, 526-532
• Qiangjian Zhang, Yunyun Wang, Yuxun Zhao, Shi-Fa Wang, Design, Synthesis and Antioxidant Application of Camphorsulfonic Acid Thiazolylhydrazone Derivatives, Chinese Journal of Organic Chemistry, 2019, 39, 9, 2616
• Shuning Chen, Yunyun Wang, Guido Schnabel, Congyue Annie Peng, Satyanarayana Lagishetty, Kerry Smith, Huizhu Yuan, Inherent Resistance to 14 alpha-Demethylation Inhibitor Fungicides in Colletotrichum truncatum Is Likely Linked to CYP51A and/or CYP51B Gene Variants, Phytopathology, 2018, 108, 11, 1263-1275
• Lijuan Yang, Mingxin Li, Yunyun Wang, Yan Zhang, Zhipeng Liu, Shutang Ruan, Zhonglong Wang, Shifa Wang
• An isocamphanyl-based fluorescent “turn-on” probe for highly sensitive and selective detection of Ga3+ and application in vivo and in vitro, Analyst, 2021, 146, 7294-7305
• Yang Yang, Yunyun Wang, Zhijie Zhang, Zhijie Zhang, Shifa Wang
• and Zhen Li
• A novel berberine-based colorimetric and fluorimetric probe for hydrazine detection, ACS Omega, 2021, 6, 31272–31281
• Shutang Ruan, Yu Gao, Yunyun Wang, Mingxin Li, Haiyan Yang, Jie Song, Zhonglong Wang
• Shifa Wang
• A novel berberine-based colorimetric and fluorimetric probe for hydrazine detection, New J. Chem., 2020, 44, 15752-15757
• Chonghui Ma, Chenliang Wu, Yunyun Wang, Zhenzhen Huang, Qiangjian Zhang, Fuhao Dong, Wen Gu, Yu Shan, Shifa Wang, Synthesis and Antitumor Activity of Novel Isolongifolic-Alkyl Dihydropyrimidinethione Derivatives, Chin. J. Org. Chem., 2019, 39, 3, 821-829
• Yao Wang, Yudian Zhang, Yunyun Wang, Han Peng, Jian Rui, Zhijie Zhang, Shifa Wang, Zhen Li, WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes, Bioscience, Biotechnology, and Biochemistry, 2017, 81, 1529–1535
• Jinlai Yang, Jian Rui, Xu Xu, Yiqin Yang, Jun Su, Haijun Xu, Yunyun Wang, Nan Sun, Shifa Wang, Fluorescence staining of salicylaldehyde azine, and applications in the determination of potassium tert-butoxide, RSC Adv., 2016, 6, 30636-30641
• Jianqiang Qian, Zhongyuan Xu, Chi Meng, Yun Liu, Hongmei Wu, Yunyun Wang, Jinxian Yang, Hongwei Zheng, Fansheng Ran
• Gong-Qing Liu
• and Yong Ling
• Redox-Activatable Theranostic Co-Prodrug for Precise Tumor Diagnosis and Selective Combination Chemotherapy, J. Med. Chem., 2022, 65, 15, 10393–10407
• Mingguang Zhang, Yang Yang, Yunyun Wang, Jia Wang, Hongyan Wu, Yongqiang Zhu, Synthesis and Evaluation of 2-Amine-4-oxyphosaniline Pyrimidine Derivatives as EGFR L858R/T790M/C797S Mutant Inhibitors, Chemical and Pharmaceutical Bulletin, 2023, 71, 140-147
• Mingguang Zhang, Zhongbao Bi, Yunyun Wang, Yuxun Zhao, Yang Yang, Yongqiang Zhu, Shifa Wang, A practical synthesis of 3-chloro-2,4-difluoro-5-hydroxybenzoic acid, Journal of Chemical Research, 2020, 45, 1-2, 174751982093225