Z. Christine Bian

Accomplished Biologist with a proven track record at the University of Cincinnati Medical School, adept in leveraging statistical data analysis and research proficiency to uncover vital patterns in biological data. Skilled in developing innovative solutions to potential cancer therapy, the work has significantly contributed to basic cancer research and advanced molecular biology knowledge.

Publications

• Biglycan promotes cancer stem cell properties, NFκB signaling and metastatic potential in breast cancer cells. Kanakaraju Manupati, Ritama Paul, Mingang Hao, Michael Haas, Zhaoqun Christine Bian, Tammy M. Holm, Jun Lin Guan, Syn Kok Yeo. Cancers 2022, 14(2), 455 https://doi.org/10.3390/cancers14020455
• Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling. Fuchun Yang, Shiva Kalantari, Banzhan Ruan, Shaogang Sun, Zhaoqun Bian & Jun-Lin Guan.Nature Communications. 22 February 2023. https://doi.org/10.1038/s41467-023-36562-5
• Inhibition of Autophagy Mitigates Cell Migration and Invasion in Thyroid Cancer (2022). Tammy M Holm, Z. Christine Bian, Kanakaraju Manupati, Jun-Lin Guan. Surgery. Jan; 171(1) 235-244
• Suppression of FIP200 and autophagy by tumor derived lactate promotes naïve T cell apoptosis and affects tumor immunity(2017). H. Xia, W. Wang, J. Crespo, I. Kryczek, W. Li, S. Wei, Z. C. Bian, T. Maj, M. He, J. R. Liu, Y. He, R. Rattan, A. Munkarah, J.-L. Guan and W. Zou. Science Immunology. Nov 17; 2(17). pii: eaan4631. doi: 10.1126/sciimmunol.aan4631.
• FIP200 is required for maintenance and differentiation of postnatal neural stem cells (2013). C. Wang, C.-C. Liang, Z. C. Bian, Y. Zhu and J.-L. Guan. Nature Neurosci. 16: 532-542.
• Identification of the transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression (2003). J. Zhao, Z. C. Bian, K. Yee, B. P.C. Chen, S. Chien, J. -L. Guan. Molecular Cell 11: 1503-1515.
• Differential regulation of Pyk2 and Focal Adhesion (FAK): the C-terminal domain of FAK confers response to cell adhesion (1998). C. Zheng, Z. Xing, Z.C. Bian, C. Guo, A. Akbay, L. Warner and J. -L. Guan. J. Biol. Chem. 273: 2384-2389.
• Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate (1998). C. Guo, C. Zheng, I. Martin-Padura, Z.C. Bian and J. -L. Guan. Eur. J. Biochem. 257: 403-408.
• Asn-265 of frog kainate binding protein is a functional glycosylation site: implications for the transmembrane topology of glutamate receptors (1995). Z.G. Wo, Z.C. Bian and R.E. Oswald. FEBS Letters 368: 230-234.
• Studies on C-glycosides XXVII. Synthesis of acyclic bayin analogues (1991). M. Cai, Z. C. Bian L. Qiao and D. Wang. Acta Chimica Sinica 49: 593-599.

References

Available upon request