Zeta Doufexi
Summary
Biomedical Engineer with a strong background in small molecule drug discovery and early-stage drug development, looking to expand into biologics research. Experienced in evaluating new targets, designing high-throughput screening (HTS) pipelines, and analyzing preclinical data to assess therapeutic potential. Skilled in cell-based assays, immunoassays (ELISAs, Western blots), and multi-panel flow cytometry using the Aurora Cytek platform. Proficient in automation and liquid handling systems, ensuring accuracy and reproducibility. Expert in data analysis and presentation using GraphPad Prism and LIMS. A proactive problem solver with a hands-on approach, committed to integrating innovative screening technologies to advance translational research.
Overview
3
3
years of professional experience
Work History
Sr. Research Associate - New Target Identification
Oddity Labs
Boston, MA
01.2025 - Current
- Drove new target identification and prioritization in skin inflammation by conducting deep literature searches, analyzing emerging scientific data, and engaging with KOLs to assess clinical relevance and feasibility.
- Conduct FTO and IP landscape analyses by reviewing patents, assessing claim structures, and identifying potential risks to guide R&D and M&A decisions.
Research Associate - Small Molecule Discovery
Oddity Labs
Boston , MA
01.2024 - 12.2024
- Developed assay cascade leveraging enzymatic (HTRF, ELISA) and cell-based assays to enable the identification of 3 potential drug candidates for skin inflammatory diseases.
- Applied multivariate statistical modeling (PCA) and nonlinear dimensionality reduction techniques (UMAP, t-SNE) to extract key patterns from high-dimensional scRNA-seq data, generating actionable biological insights to guide experimental design.
- Streamlined high-throughput screening (HTS) methodologies by developing SOPs and conducting team training sessions, boosting workflow efficiency by 25%.
- Strategically managed CRO partnerships to outsource assay development, achieving 10% cost savings.
Research Associate - 3D Cardiac Tissue Engineering
Columbia University: Laboratory for Stem Cells
New York, NY
09.2022 - 12.2023
- Differentiated induced pluripotent stem cells (iPSCs) into cardiomyocytes and cardiac fibroblasts to develop 3D cardiac tissue models, characterizing genetic channelopathy-related arrhythmias through advanced calcium dye imaging and video analysis.
- Designed a CRISPR-based gene editing methodology to correct point mutations in cardiac models, resulting in significant phenotypic improvements.
Education
MSc - Biomedical Engineering (GPA 4.0/4.0)
Columbia University
New York, NY12-2023
BSc & MSc - Chemical Engineering (GPA 8.5/10)
National Technical University of Athens
Athens, Greece07-2022
Minors - Economics (GPA 4.0/4.0) & Biology (GPA 4.0/4.0)
Deree - The American College of Greece
Athens, Greece05-2022
Skills
- Technical Expertise: Python (NumPy, Pandas), PCA, Graphpad Prism, Jira, Patsnap, SciFinder, UMAP, t-SNE, Excel (Pivot Tables, Functions), HTS, CRISPR, Flow Cytometry, High Content Imaging, qPCR, DNA/RNA isolation, ELISA, Western Blot, Liquid Handling Platforms
- Project management: Analytical Problem-Solving, Strategic Planning, Task Delegation, Deadline Management, Reporting to Leadership, Effective Communication, Client Relationship Management
Timeline
Sr. Research Associate - New Target Identification
Oddity Labs
01.2025 - Current
Research Associate - Small Molecule Discovery
Oddity Labs
01.2024 - 12.2024
Research Associate - 3D Cardiac Tissue Engineering
Columbia University: Laboratory for Stem Cells
09.2022 - 12.2023
MSc - Biomedical Engineering (GPA 4.0/4.0)
Columbia University
BSc & MSc - Chemical Engineering (GPA 8.5/10)
National Technical University of Athens
Minors - Economics (GPA 4.0/4.0) & Biology (GPA 4.0/4.0)
Deree - The American College of Greece