Zhongyang "Adam" Shi

Working with postdoc Gao Shuliang to investigate the role of various TSC2 genes encoding RNA constructs that leads to lymphangioleiomyomatosis (LAM). Evaluating the efficacy of ZUGC-mRNA in developing lipid nanoparticle vaccines for treating LAM.

Working with PhD candidate Chen Mengting to explore a nucleic acid vaccine that efficiently inhibits the synthesis of mutated ANGPTL3 proteins, regulating lipid metabolism thus controlling the development of potential liver-cancer.

Working with PhD candidate Cui Shangyuan to assess drug delivery methods using nanofabrication technology with natural biopolymers (pending publication).

Worked with PI Lu Nan to examine the signaling system of glioblastoma (GBM). By analyzing patient samples, we've conducted the STING therapeutic pathway to boost the recognition of NK cells on cancerous cells.

Publication: Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme | Link: https://pubmed.ncbi.nlm.nih.gov/35464443/