Wen Xiao
Los Angeles,CA
Summary
- Self-motivated PhD level scientist with over 13 years of R&D experience in academia that resulted in 17 peer-reviewed publications.
- Independent and creative problem solver, offering deep knowledge in molecular biology, genome editing and RNA biology, complemented with hands-on experience in a wide variety of cellular and molecular assays.
- Effective communicator, interacting with cross-functional teams, experience in mentorship.
Overview
13
13
years of professional experience
Work History
Assistant Project Scientist
University Of California, Los Angeles
09.2022 - Current
- Identified a well studied nuclear lincRNA can export to the cytoplasm and encode small peptides in developing neurons and plays an important role in neuron development/maturation (Submitted to Nature).
- Validated the expression of Xist dampening gene by smFISH in collaboration of Kathrin Plath lab at UCLA (Cell, 2024).
- Characterization of some germline specific gene expression by Tissue FISH in C. elegans. in collaboration with Patrick Allard lab at UCLA (Cell reports, 2023).
Postdoctoral Research Scholar
University Of California, Los Angeles
11.2018 - 07.2022
- Developed a high-efficient and cost-effective FISH probe labeling method to investigate the spatial interactions between retained introns of mRNA and subcellular compartments in single cell (RNA, 2023).
- Identified developmental gene regulation through intron retention and nuclear anchoring in fractionated compartments in collaboration with my colleague (Genome research, 2021).
- Established primary neuron isolation and culture system for analyzing neural maturation and development.
- Established a protocol to efficiently differentiate mouse embryonic cells toward Motor or Glutamatergic neurons.
Research Assistant
University Of Chinese Academy Of Sciences
08.2016 - 10.2017
- Identified entacapone, a catechol-O-methyltransferase inhibitor used in the treatment of Parkinson’s disease, as an inhibitor of a m6A demethylase-FTO ( Sci. Transl. Med., 2019).
Ph.D. Student
University Of Chinese Academy Of Sciences
09.2010 - 07.2016
- Characterized a m6A reader protein YTHDC1 in regulation of alternative splicing of mRNA in mammalian cell (Mol. Cell, 2016).
- Identified WTAP as a regulatory subunit of m6A methyl-transferase in regulation of m6A formation for mRNA (Cell Res., 2014).
- Identified entacapone, a catechol-O-methyltransferase inhibitor used in the treatment of Parkinson’s disease, as an inhibitor of a m6A demethylase-FTO (Sci. Transl. Med., 2019).
Education
Ph.D. - Biochemistry And Molecular Biology
University Of Chinese Academy of Sciences
Beijing, China07.2016
Bachelor of Science - Agricluture
Shandong Agricultural University
Tai'an, China07.2010
Skills
Cell Biology: mouse and human stem cell maintenance, primary neuron isolation and culture from mouse embryos , cell lines, confocal microscopy
Immunology: immune-blot, immunofluorescence, immunocyto- & histochemistry, immunoprecipitation
Molecular Biology: PCR, qRT-PCR, Western blot, DNA & RNA extraction
Microbiology: Isolation, cultivation, and maintenance of bacteria, AAV viruse packaging
Software: GraphPad Prism, Image J, Office, Adobe illustrator, R language
Communication skills: Presentation & publication of scientific data, coordination of interdisciplinary projects, training and supervision of technical staff
Timeline
Assistant Project Scientist
University Of California, Los Angeles
09.2022 - Current
Postdoctoral Research Scholar
University Of California, Los Angeles
11.2018 - 07.2022
Research Assistant
University Of Chinese Academy Of Sciences
08.2016 - 10.2017
Ph.D. Student
University Of Chinese Academy Of Sciences
09.2010 - 07.2016
Ph.D. - Biochemistry And Molecular Biology
University Of Chinese Academy of Sciences
Bachelor of Science - Agricluture
Shandong Agricultural University
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