Albert D. Kim

Before joining the 10x Genomics Cell Biology and Applications team I was an NIH Ruth L. Kirschstein National Research Service Award (NRSA) fellow at USC Stem Cell in the laboratory of Andrew P. McMahon. I investigated comparative developmental biology of the mouse and human kidney with a focus on how the body's primary filter is established by nephron, interstitial, and endothelial progenitors leveraging insights identified from single cell genomic analysis in collaboration with Kun Zhang's laboratory at UCSD. I utilized high resolution microscopy and high throughput cell-based assays to identify genetically and chemically tractable signaling pathways for regulation of these coordinated processes. The developmental biology of vertebrate organs has been my career-long focus shaped from my graduate studies in the laboratory of David Traver at UCSD. My goals at 10x Genomics are to expand the resolution and the applicability of single cell and spatial genomics methods to derive more complete insights for biology and personalized medicine. Before I used to think about the biology of a village of cells of one organ at a time and now I need to consider how researchers will mine the universe of biological specimens in their current research needs but also needs that they haven't thought of yet.

Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Bertrand JY , Kim AD , Violette EP, Stachura DL, Cisson JL, Traver D. Development. 2007 Dec;134(23):4147-56. Epub 2007 Oct 24. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Bertrand JY , Kim AD , Teng S, Traver D. Development. 2008 May;135(10):1853-62. Epub 2008 Apr 16. 

A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Clements WK, Kim AD, Ong KG, Moore JC, Lawson ND, Traver D. Nature. 2011 Jun 8;474(7350):220-4. doi: 10.1038/nature10107. PMID: 21654806 Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling. Kobayashi I, Kobayashi-Sun J, Kim AD, Pouget C, Fujita N, Suda T, Traver D. Nature. 2014 Aug 21;512(7514):319-23. doi: 10.1038/nature13623. Epub 2014 Aug 13. 

Discrete Notch signaling requirements in the specification of hematopoietic stem cells. Kim AD, Melick C, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Traver D. EMBO J. 2014 Sep 17. pii: e201488784. Proinflammatory signaling regulates hematopoietic stem cell emergence. Espín- Palazón R, Stachura DL, Campbell CA, García-Moreno D, Del Cid N, Kim AD, Candel S, Meseguer J, Mulero V, Traver D.
Cell. 2014 Nov 20;159(5):1070-85. doi: 10.1016/j.cell.2014.10.031. Epub 2014 Nov 6. FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling. Lee Y, Manegold JE, Kim AD, Pouget C, Stachura DL, Clements WK, Traver D.
Nat Commun. 2014 Nov 27;5:5583. doi: 10.1038/ncomms6583. 

Cell signaling pathways involved in hematopoietic stem cell specification. Kim AD, Stachura DL, Traver D. Exp Cell Res. 2014 Oct 29;329(Hrabe de Angelis et al):227233. doi: 10.1016/j.yexcr.2014.10.011. Review. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. O'Brien LL, Guo Q, Bahrami- Samani E, Park JS, Hasso SM, Lee YJ, Fang A, Kim AD, Guo J, Hong TM, Peterson KA, Lozanoff S, Raviram R, Ren B, Fogelgren B, Smith AD, Valouev A, McMahon AP. PLoS Genet. 2018 Jan 29;14(1):e1007181. doi: 10.1371/journal.pgen.1007181. eCollection 2018 Jan. PubMed PMID: 29377931; PubMed Central PMCID: PMC5805373. 

Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. Lindström NO , Guo J , Kim AD , Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Basking L, Grubbs B, McMahon JA, Smith AD, McMahon AP. J Am Soc Nephrol. 2018 Mar;29(3):806-824. doi: 10.1681/ASN.2017080890. Epub 2018 Feb 15. PubMed PMID: 29449449; PubMed Central PMCID: PMC5827607. 

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time- Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis. Lindström NO, De Sena Brandine G, Tran T, Ransick A, Suh G, Guo J, Kim AD, Parvez RK, Ruffins SW, Rutledge EA, Thornton ME, Grubbs B, McMahon JA, Smith AD, McMahon AP. Dev Cell. 2018 Jun 4;45(5):651-660.e4. doi: 10.1016/j.devcel.2018.05.010. PubMed PMID: 29870722. 

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. Lindström NO, McMahon JA, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Basking L, Grubbs B, Kesselman C, McMahon AP. J Am Soc Nephrol. 2018 Mar;29(3):785-805. doi: 10.1681/ASN.2017080887. Epub 2018 Feb 15. PubMed PMID: 29449453; PubMed Central PMCID: PMC5827606. 

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. Tran T, Lindström NO, Ransick A, De Sena Brandine G, Guo Q, Kim AD, Der B, Peti-Peterdi J, Smith AD, Thornton M, Grubbs B, McMahon JA, McMahon AP. Dev Cell. 2019 Jul 1;50(1):102-116.e6. doi: 10.1016/j.devcel.2019.06.001. PMID: 31265809. 

Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney.Ransick A, Lindström NO, Liu J, Zhu Q, Guo JJ, Alvarado GF, Kim AD, Black HG, Kim J, McMahon AP.Dev Cell. 2019 Nov 4;51(3):399-413.e7. doi: 10.1016/j.devcel.2019.10.005.PMID: 31689386 Free PMC article. 

Spatial transcriptional mapping of the human nephrogenic program. Lindström NO, Sealfon R, Chen X, Parvez RK, Ransick A, De Sena Brandine G, Guo J, Hill B, Tran T, Kim AD, Zhou J, Tadych A, Watters A, Wong A, Lovero E, Grubbs BH, Thornton ME, McMahon JA, Smith AD, Ruffins SW, Armit C, Troyanskaya OG, McMahon AP.Dev Cell. 2021 Aug 23;56(16):2381-2398.e6. doi: 10.1016/j.devcel.2021.07.017.PMID: 34428401 Free PMC article. 

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, Lindström N, Brown A, Oxburgh L, Ren B, McMahon AP.Elife. 2021 Feb 15;10:e64444. doi: 10.7554/eLife.64444. PMID: 33587034 Free PMC article. 

Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors.Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z.Nat Commun. 2021 Jun 15;12(1):3641. doi: 10.1038/s41467-021-23911-5. PMID: 34131121 Free PMC article.

• Jill L. Herschleb, Ph.D. (she/her/hers) Senior Director, Cell Biology and Applications
  jill@10xgenomics.com 10x Genomics Office 925 123 4567 | Mobile 415 404 2092 6230 Stoneridge Mall Road
  Pleasanton, CA 94588-3260 | 10xgenomics.com
• Andrew P. McMahon, Ph.D., W.M. Keck Provost Professor and Chair of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, 1425 San Pablo Street, BCC 312, Los Angeles, CA, 90033-9080, 323-442-7847, 323-442-8077, amcmahon@med.usc.edu
• Kun Zhang, Ph.D., Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0412, 858-822-7876, 858-822-3635, 858-534-5722, kzhang@eng.ucsd.edu
• David Traver, Ph.D., Professor, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0380, (858) 822-4593, (858) 534-5457, dtraver@ucsd.edu