Althea E. Escorce
Philadelphia,PA
Summary
Seasoned Research Scientist with a robust background at Wuxi AppTec and Thomas Jefferson University, specializing in CRISPR/Cas9 and data analytics. Demonstrated excellence in developing AAV vector therapies and leading FDA approval processes. Skilled in scientific writing and client management, with a proven track record of pioneering research methods and driving innovation in drug discovery.
Overview
9
9
years of professional experience
Work History
Research Scientist/Technical Operations Specialist
Wuxi AppTec
Philadelphia, PA
01.2022 - Current
- Develops assays to quantify client samples (analytical and raw material)
- Assisted in the FDA approval of the BLA for client Mesoderm
- Analyzes data and present data to clients
- Authors R&D and GMP test methods, CPs and QPs
- Conducts experiments such as UPLC, ddPCR, and ELISA
- Authors data reports (R&D) and presents results
- Performs techniques such as western blots, flow cytometry and gel electrophoresis
- Writes and edits SOPs and other regulatory assays
- Maintains cell culture and perform assays
- Test client samples via flow cytometry
- Performs in vitro and in vivo techniques
- Trains junior research associates
- Orders and maintains chemical inventory
- Develops AAV (AAV9 &AAV6) vector therapies and quantify capsids
- Maintains FDA regulatory paperwork and equipment calibration
Research Scientist
Thomas Jefferson University
Philadelphia, PA
09.2018 - 01.2022
- Developed new protocols to create genetic mouse lines
- Has knowledge and practice in GLP, GDP, and GMP
- Performed ELISA, PCR, Q-PCR, and electrophoresis
- Ran Western Blots and Southern Blots
- Proficient in DNA and RNA extraction
- Organized the mice genotyping database for the laboratory
- Conducted a variety of cloning techniques, such as CRISPR/Cas9 genome editing
- Authored research papers and test methods
- Trained colleagues, graduate students and undergraduate students
- Maintained regulatory paperwork and maintained laboratory equipment
Clinical Research Technician
Thomas Jefferson University
Philadelphia, PA
09.2017 - 06.2018
- Collected blood samples from patients and created databases
- Cultured cells (tumor analysis), experience counting cells, including human cancer cells
- Organized and orchestrated mouse experiments (subcutaneous injections and other protocols)
- Conducted various scientific techniques such as immunofluorescence technique
- Authored different protocols for cancer research projects
- Formulated different flow cytometry and molecular-based PCR-assays
- Analyzed patient blood samples for different experiments
Research Technician
University of Pennsylvania
04.2016 - 09.2017
- Obtained and maintained histological samples
- Created protocols for research studies
- Performed molecular sequencing techniques such as RNA sequencing and CRISPR
- Organized the system of laboratory mice lines
- Conducted PCR, qPCR, flow cytometry, ELISA, and immunohistochemistry for all lab projects
Clinical Research Assistant
University of Pennsylvania
09.2015 - 03.2016
- Recruited patients for clinical trials for sleep studies
- Created the protocol for the sleep studies with colleagues
- Organized IRB paperwork
- Created the database for behavioral trial
Education
Master of Science - Cellular Developmental Biology
05.2022
Bachelor of Arts - Public Health
05.2017
Bachelor of Science - Biology
05.2016
High School Diploma -
06.2011
Skills
- Immunofluorescence
- QPCR
- Western blotting
- Flow cytometry
- Cell culture
- Cell potency practices
- Cancer Biology
- CRISPR/Cas9
- Molecular-based PCR
- Miniprep
- Mammalian cell culture
- Laboratory logistics
- Data entry
- Microsoft Office Suite
- Method validation
- Scientific writing
- SharePoint
- Client management software
- Research and publication
- Drug discovery
- Research proposals
- Laboratory techniques
- Deep-dive data analysis
- Feasibility testing
- Clinical assays
- Paper writing
- Root-cause analysis
- Quantitative research
- Data analytics
- Research methods
- Computational modeling
- File management
- Lab and field testing
- Experiment design
- Experimental design
- Bioinformatics
Honors andnawards
- Research Diversity Supplement Grant, 2021
- Scholarship, Gates Millennium Graduate School Tuition Award, 2017
- Scholarship, Mayors University of Pennsylvania Scholarship Award, 2012
- The award, Thompson Award for Leadership, 2012
- Scholarship, Taiwanese Association of Greater Philadelphia, 2012
- Scholarship, Gates Millennium Scholarship recipient, 2011
- Valedictorian, Germantown High School, 2011
- Scholarship, Delta Sigma Theta recipient, 2011
Languages
French
Professional
References
References available upon request.
Timeline
Research Scientist/Technical Operations Specialist
Wuxi AppTec
01.2022 - Current
Research Scientist
Thomas Jefferson University
09.2018 - 01.2022
Clinical Research Technician
Thomas Jefferson University
09.2017 - 06.2018
Research Technician
University of Pennsylvania
04.2016 - 09.2017
Clinical Research Assistant
University of Pennsylvania
09.2015 - 03.2016
Master of Science - Cellular Developmental Biology
Bachelor of Arts - Public Health
Bachelor of Science - Biology
High School Diploma -
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