Alvaro G. Alvarado
Los Angeles,CA
Summary
Cancer researcher with extensive experience investigating glioblastoma
biology, tumor heterogeneity, and immune evasion. Proven track record in
patient-derived models, developing computational pipelines and
interdisciplinary collaborations. Passionate about advancing personalized
cancer care through translational research and innovative technologies.
Overview
14
14
years of professional experience
Work History
Assistant Project Scientist
University of California, Los Angeles
06.2022 - Current
- Lead pathway- and immune-focused glioblastoma research in collaboration with clinicians and data scientists.
- Developed computational pipeline to assess tumor heterogeneity via pathway enrichment.
- Designed and implemented CyTOF panels for immune profiling of patient-derived tumor samples.
Postdoctoral Fellow
UCLA Semel Institute for Neuroscience
09.2016 - 05.2022
- Investigated glioblastoma subpopulations and their interaction with immune cells.
- Identified immune-evasive cancer stem cell phenotypes relevant to patient prognosis.
- Collaborated in multi-omics studies on therapeutic resistance mechanisms.
Graduate Researcher
Case Western Reserve University / Cleveland Clinic
07.2011 - 05.2016
- Characterized glioblastoma stem cells and their regulatory pathways.
- Published foundational studies on tumor microenvironment and adhesion signaling.
- Led multiple projects utilizing patient-derived glioma lines.
Education
Ph.D. - Molecular Medicine
Case Western Reserve University
Cleveland, OH05-2016
B.S. - Biology
Universidad Peruana Cayetano Heredia
Lima, Peru12-2008
Skills
- Cancer Biology
- Immuno-oncology
- Tumor Heterogeneity
- Microenvironment
- Data Analysis
- Mass Cytometry
- Flow Cytometry
- Functional Genomics
- Pathway Analysis
- Patient-Derived Models
- Translational Research
- Clinical Collaboration
Awards
- UC President’s Postdoctoral Fellowship, 07/2019–06/2021
- Doctoral Excellence Award, Case Western Reserve University, 05/2016
- Elsa Albrecht Award for Best Graduate Publication, 05/2016
- Bumpus Award Finalist, Cleveland Clinic Foundation, 04/2015
Research Support
- Title: Reconciling Glioblastoma Heterogeneity Using a Pathway-Based
Approach
Fellowship: UC President’s Postdoctoral Fellowship Program
Role: Principal Postdoctoral Investigator
Duration: 07/2019 – 06/2021
Professional Leadership Service
- Reviewer, Cell Reports, Translational Oncology, Scientific Reports
- Editorial Board, Translational Oncology, 01/20–Present
- President, Diversity Initiative Group, CCLRI, 01/13–12/16
Presentations
- Speaker, CAMPOS Research Colloquium, UC Riverside, 2022
- Speaker, Spring Seminar Series, University of California Irvine, 2021
- Oral Presenter, Society for Neuro-Oncology Annual Meeting 2015,16,19
Selected Publications
- Adhesion/microRNA integration in GBM self-renewal, Neuro Oncol, 2016
- CSC/MDSC interaction facilitates immune evasion, Stem Cells, 2016
- GBM stem cell immune evasion via TLR4, Cell Stem Cell, 2017
- Resistance to mTOR inhibitors in GBM, Neuro Oncol, 2017
- Peripheral immune signatures in GBM prognosis, JCI Insight, 2018
- Capecitabine modulates MDSCs in GBM, JCI Insight, 2019
- Pathway-based sensitivity to E2F1 inhibition, Cancer Res Commun, 2022
- P300 promotes vascular mimicry and resistance Nat Commun, 2022
Timeline
Assistant Project Scientist
University of California, Los Angeles
06.2022 - Current
Postdoctoral Fellow
UCLA Semel Institute for Neuroscience
09.2016 - 05.2022
Graduate Researcher
Case Western Reserve University / Cleveland Clinic
07.2011 - 05.2016
Ph.D. - Molecular Medicine
Case Western Reserve University
B.S. - Biology
Universidad Peruana Cayetano Heredia
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