Arnab Sarkar

Dynamic research professional with research experience at Oregon Health and Science University, UT Health San Antonio and the University of Houston, specializing in CRISPR-Cas9 technology and pediatric cancer projects. Demonstrated expertise in molecular analysis and bioinformatics, complemented by a strong aptitude for problem-solving. Recognized for significant contributions to advancing scientific understanding through innovative research initiatives. Aiming to leverage skills in a collaborative environment focused on impactful scientific discoveries.

A LINCRNA00273 for diagnosis and estimation of cancer progression, 640/KOL/2015

• Date of Birth: 03/18/88
• Gender: Male
• Nationality: Indian
• Marital Status: Married

• Bengali
• English
• Hindi

• Eugenol and capsaicin exhibit anti-metastatic activity via modulating TGF-β signaling in Gastric Carcinoma, Food & Function, 2020
• Induction of Apoptosis by Eugenol and Capsaicin in Human Gastric Cancer AGS Cells - Elucidating the Role of p53, Asian Pacific Journal of Cancer Prevention, 2015
• TGFβ mediated LINC00273 upregulation sponges mir200a‐3p and promotes invasion and metastasis by activating ZEB1, J Cell Physiol, 2020
• LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness, Oncotarget, 2017
• Parkia javanica Extract Induces Apoptosis in S-180 Cells via the Intrinsic Pathway of Apoptosis, Nutrition and Cancer, 2016
• The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1α protein synthesis via PI3K/Akt pathway, BioFactors, 2019

• Advanced fluorescence Microscopy, Department of Zoology West Bengal State University
• Bioinformatics from sequence and structural perspectives, Department of Biochemistry and Biophysics at University of Kalyani
• Advanced Bioinformatics & NGS-Chip seq data Analysis, ArrayGen Technologies Pvt. Ltd.
• Exploring the modern approach in biological science: From genome to organism, 2015, Sidho Kanho Birsha University (SKBU), Purulia
• National Consortium for an integrated research on molecular medicine: Search for novel biopharmaceuticals from natural resources of West Bengal (CRIMM, WBSU), Department of Zoology, West Bengal State University, West Bengal, India

• Investigating the pro-apoptotic and antimetastatic activities of eugenol and capsaicin in gastric carcinoma, Cell cycle assay, Annexin V, co-immunoprecipitation of caspase9-cytochrome c and western blot analysis showed that both the phytochemicals exhibit anti-proliferative activity by inducing apoptosis.
• Investigating the role of TGFβ induced invasion and metastasis by upregulating LINC00273 and modulating miR200a/zeb1 feedback loop, In this project we determined the novel target LINC00273 that promotes cancer metastasis.
• Targeting Oncogenic RAS Signaling in NF1-associated Malignant Peripheral Nerve Sheath Tumor, Using loss/gain of function studies, we demonstrate that NF1 negatively regulates RAS/ERK signaling through C/BRAF.

• Got 3rd position in a oral presentation of GCCRI Research Retreat 2024.

https://www.linkedin.com/in/arnab-sarkar-809398197/

GATE in Lifesciences in 2011 and 2012

CSIR/UGC-NET-Lectureship in Lifesciences in 2012, 2014, 2015

CSIR-Senior research fellowship (SRF-Direct) in General Biology in 2018