Arpita Agrawal
kendall park
Summary
Process Chemist specializing in multi-step organic synthesis and process development for pharmaceutical applications. Expertise in route scouting, reaction optimization, and analytical characterization using HPLC, LC-MS, and NMR. Demonstrated success in cross-functional collaboration and maintaining rigorous documentation while enhancing process efficiency from lab to pilot scale.
Overview
18
18
years of professional experience
Work History
Senior Research Chemist II
Porton-Jstar Research Inc.
Cranbury
07.2022 - Current
- Directed scale-up operations by defining critical process parameters (CPPs) and quality attributes (CQAs).
- Executed studies on impurity fate and purge to support regulatory submissions effectively.
- Collaborated with cross-functional teams to facilitate tech transfer and production readiness.
- Optimized processes resulting in improved reproducibility and reduced cycle times for small-molecule APIs.
- Authored comprehensive regulatory documentation aligned with ICH standards.
- Mentored junior chemists, enhancing their skills in scientific compliance and excellence.
- Led PRD activities for APIs/intermediates, ensuring high yield and purity metrics during transfers.
- Utilized HPLC, LC-MS, and NMR techniques for reaction monitoring and impurity identification.
Chemist, Research and Development
SPEX (Antylia Scientific)
Metuchen
07.2021 - 06.2022
- Developed and launched new analytical standards and products, addressing emerging market needs.
- Pioneered cost-saving in-house synthesis of raw materials and stable isotope-labeled compounds.
- Advanced analytical methods for isomeric separation and protein standards for drug discovery.
Chemist III / Team Lead – Organic Manufacturing
Spex Certiprep (Cole Parmer)
Metuchen
05.2018 - 07.2020
- Promoted to Team Lead, managing 4–6 chemists and overseeing daily operations.
- Ensured compliance with safety, quality, and regulatory requirements.
- Led continuous improvement initiatives, enhancing product quality and operational efficiency.
Research Scientist
Ranbaxy Laboratories Limited
Gurgaon
04.2008 - 07.2009
- Designed and executed de novo synthetic routes for APIs, supporting successful biological evaluations and regulatory submissions.
Education
Ph.D. - Chemistry
University of Delhi
New Delhi, India01.2007
M.Sc. - Chemistry
Banaras Hindu University
Varanasi, India01.2001
B.Sc. - Chemistry
MMV, Banaras Hindu University
Varanasi, India01.1999
Skills
- Process optimization strategies
- Regulatory adherence (ICH, FDA, cGMP)
- Lab to kilo-lab technology transfer
- Impurity mapping techniques
- Quality assurance and risk management
- Innovative synthetic methodologies
- Route scouting and reaction optimization
- Scale-up processes (mg to kg)
- Solvent screening and reagent selection
- Analytical techniques: HPLC/UPLC, LC-MS, NMR (¹H, ¹³C), TLC, IR
- Purity profiling and reaction monitoring
- ChemDraw software proficiency
- ELN/LIMS , MS office
Publications
- Molybdenum in Organic Synthesis. A Review, Org. Prep. Proc Int., 36, 3, 201-276, 2004
- Microwave Mediated Debromination of Vicinal-Dibromides, Synth. Commun., 36, 207-209, 2006
- A Novel Two Step Synthesis of 3,4-dihydro-4-oxo-5H-pyrano[2,3-d]pyrimidines, Heterocycles, 68, 1885-1892, 2006
- 5,5-Diaryl and 5-Alkyl-3-phenyl-4-imidazolidones: A Novel Synthesis, J. Heterocycl. Chem., 46, 10007, 2009
- Oxidation of Chalcogenides using the Peroxo Complex of Molybdenum [MoO(O)(H2O)(hmpa)], J. Braz. Chem. Soc., 20, 1256-1261, 2009
Research
- Developed innovative, reagent-free microwave-assisted debromination techniques.
- Designed high-yield, two-step syntheses for complex heterocycles.
- Established selective desulfurization and oxidation methodologies for advanced intermediates.
Timeline
Senior Research Chemist II
Porton-Jstar Research Inc.
07.2022 - Current
Chemist, Research and Development
SPEX (Antylia Scientific)
07.2021 - 06.2022
Chemist III / Team Lead – Organic Manufacturing
Spex Certiprep (Cole Parmer)
05.2018 - 07.2020
Research Scientist
Ranbaxy Laboratories Limited
04.2008 - 07.2009
Ph.D. - Chemistry
University of Delhi
M.Sc. - Chemistry
Banaras Hindu University
B.Sc. - Chemistry
MMV, Banaras Hindu University