Aurpita Shaha

Accomplished Postdoctoral Researcher from Fox Chase Cancer Center, FCCC, adept in experimental design and advanced data analysis. Excelled in mentoring, enhancing team collaboration and research output. Contributed significantly to high-impact publications, demonstrating exceptional scientific writing and interpersonal skills. Proven track record in overcoming technical challenges, underscoring adaptability and critical thinking.

1. Early Career: After finishing a four-year bachelor’s degree program I have started my master’s in pharmacy at Rajshahi University, Bangladesh. My master’s thesis work on microbiology has been published in the following two journals:

a) Shaha A., Haque A., Haque U., Islam A., 2016. Identification of Bacteria that Contaminate Stored Streptomycin Species at 4°C. Int J Curr Micro Biol App Sci 5(9): 617-625 5.

b) Shaha A., Haque A., Islam A., 2016.Studies on secondary metabolites of Streptomyces Species Contaminated Bacteria. World Journal of pharmacy and Pharmaceutical Sciences 5(11): 218-234

2. PhD Career: During my Ph.D., I explored the new therapeutics for allergy from honeybee products (Royal jelly and Brazilian green propolis) having suppressive effect on H1R gene and IL-9 gene transcriptions. I found Royal jelly, Brazilian green propolis and isolated active compound (Betuletol) from Brazilian green propolis suppressed allergic sensitive gene up-regulation both in vivo and in vitro. These findings suggest that both Royal jelly, Brazilian green propolis and Betuletol could be good therapeutics for allergic rhinitis. My findings led to three publications:

a) Shaha A.,Mizuguchi H., Kitamura Y.,Fujino H.,Masami Y.,Takeda N., Fukui H., 2018. Effect of Royal jelly and Brazilian green propolis on the signaling pathways for histamine H1 receptor and interleukin-9 gene expression responsible for the pathogenesis of the allergic rhinitis. Biological and Pharmaceutical Bulletin. 41(9): 1440-1447

b) Islam R.,Mizuguchi H., Shaha A, Nishida K, Yabumoto M, Ikeda H, Fujino H, Kitamura Y, Fukui H, Takeda N. 2018. Effect of wild grapes on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis. The Journal of Medical Investigation 65(3): 242-250

c) Shaha A., Islam R., Tanaka N., Kashiwada Y., Fukui H., Takeda N., Kitamura Y., Mizuguchi H., 2022.Betuletol, a Propolis Component, Suppresses IL-33 Gene Expression and Effective against Eosinophilia. Molecules, 27, 5459.

3. Teaching Career:

Being into academics, my teaching career contributions were to provide guidance to my students to explore and understand important concepts in science by sharing my knowledge, experiences, and practices with them and discussing issues related to their learning, problem-solving and to gather evidence to support their ideas or decisions.

4. Postdoctoral Career:

I joined Dr. Ningling Kang's lab to study mechanisms governing colorectal liver metastasis. I am working here on a project focusing on the role of CMTM6 colorectal liver metastasis, and an additional one focusing on metastatic signals of colorectal cancer cells. The following publication has been published:

a) Shaha A, Wang Y, Wang X, Wang D, Guinovart D, Liu B, Kang N. CMTM6 mediates the Warburg effect and promotes colorectal liver metastasis. Experimental and Molecular medicine, 2024. 56, 2002–2015

b) Wang X, Wang Y, Bai B, Shaha A, Bao W, He L, Wang T, Kitange J G, Kang N. 2025. PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells. Cellular and molecular Gastroenterology and Hepatology. 19-3,101429.

c) Wang Y, Wang X, Bai B, Shaha A, He X, He Y, Ye Z, Shah VH, Kang N. Targeting Src SH3 domain-mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis. Hepatology. 2024 Jan 24. doi: 10.1097/HEP.0000000000000763. Epub ahead of print. PMID: 38271673.

d)Yang F, Hilakivi-Clarke L, Shaha A, Wang Y, Wang X, Deng Y, Lai J, Kang N. 2023.Metabolic reprogramming and its clinical implication for liver cancer (HEP-22-1008). Hepatology. doi: 10.1097/HEP.0000000000000005. Epub ahead of print. PMID: 36626639.

• Microsoft Office Specialist, Excel Associate(MOS Excel)- Microsoft Corporation.

• Postdoc (The Hormel Institute at UMN)
• Postdoc (Fox Chase Cancer Center at Temple University)
• Assistant Professor (Pharmacy, PUST, Bangladesh)