Summary
Overview
Work History
Education
Skills
Awards
Additional Information
List of Publications
Selected presentations
References
Timeline
Generic

Biruhalem Taye Beyene

Bioinformatician/Infection Biologist/Medical Laboratory Scientist
Rochester, MN,Minnesota

Summary

Dedicated bioinformatician and infection biologist with 16+ years of experience in basic and clinical research in international, multidisciplinary, and collaborative teams. Expertise in bioinformatics with background in infectious diseases and clinical laboratory science. Excellent communicator with extensive teaching experience. Passionate about applying advanced bioinformatics tools for disease surveillance, diagnostics biomarkers and therapeutics targets discovery.

Overview

21
21
years of professional experience
11
11
years of post-secondary education

Work History

Research Fellow

Mayo Clinic
Rochester, MN
12.2020 - Current
  • Developed, implemented, and validated diverse bioinformatics pipelines for two independent projects tailored for next-generation sequencing (NGS) datasets.
  • Planned, prioritized, and led three independent research projects involving both bioinformatics analysis and wet lab experiments.
  • Integrated multi-omics datasets for identification plausible drug targets.
  • Collaborated with scientists within Mayo Clinic and external partners.
  • Designed and performed immunology, molecular biology, biochemistry, and histochemistry experiments.
  • Compiled data and presented results on conferences, documented for publications and grant applications.

Postdoctoral Fellow

European Molecular Biology Laboratory
Hamburg, Germany
04.2018 - 11.2020
  • Led one project on influenza virus infection cycle pathway modeling.
  • Applied systems biology and pharmacology for computational drug-target prioritization.
  • Established virus propagation and antiviral assays.
  • Discovered four drug-target pairs with novel anti-influenza virus activity.
  • Developed grant proposal and awarded "Seal of Excellence - Marie Curie Actions".

Assistant Professor/Lecturer

Addis Ababa University
Addis Ababa, Ethiopia
12.2009 - 03.2018
  • Developed bioinformatics course syllabus for graduate students.
  • Coordinated graduate and undergraduate student
    visit, mentored five graduate and one undergraduate students.
  • Taught courses including Bioinformatics (40h), Microbiology (3x 48 hrs), Parasitology (16 hrs), Communicable Disease Control
    (2x 32hrs), Clinical Chemistry (64 hrs), Urinalysis (32 hrs), Clinical Laboratory Management (32 hrs), Principle of Genetics (48 hrs), Malaria prevention and control (3x 24 hrs).
  • Provided bioinformatics support for one collaborative projects on tuberculosis biomarker discovery.
  • Conducted research on epidemiology of tuberculosis and salmonella.
  • Established collaboration with J. Craig Venter Institute and contributed to research grant writing: "Systems Biology for Molecular Analysis of Tuberculosis in Ethiopia." funded by NIH-H3Africa.

Medical Laboratory Technologist

ALERT Hospital
Addis Ababa, Ethiopia
10.2002 - 12.2009
  • Conducted different clinical laboratory tests (Microbiology, Parasitology, Immunology, Hematology, Clinical chemistry, Serology, Urinalysis, and Mycology).
  • Assessed quality of five departments of ALERT clinical laboratory.
  • Prepared and edited Standard Operating Procedures (SOP) for different types of tests and laboratory safety documents.

Education

Ph.D. - Bioinformatics

Nanyang Technological University/BII A*STAR
Singapore
08.2013 - 01.2018

Master of Science - Tropical And Infectious Diseases

Addis Ababa University
Addis Ababa
10.2007 - 07.2009

Bachelor of Science - Medical Laboratory Technology

Addis Ababa University
Addis Ababa
10.2004 - 08.2007

Diploma - Medical Laboratory Technology

Jimma University
Jimma, Ethiopia
09.2000 - 07.2002

Skills

    Proficient in analysis of whole genome sequencing, bulk RNA-seq, single-cell RNA-seq, transcriptomics, proteomics, functional genomics, network, and systems biology data

undefined

Awards

  • "Seal of Excellence - Marie Curie Actions" award | 2020 | EMBL Hamburg
  • Research Grant Award | Addis Ababa University | 2011 – 2012 | Ethiopia.
  • Scholarship Award | Singapore International Graduate Award (SINGA) | 2013 – 2017 | Singapore.
  • Travel Award | Singapore Society for Microbiology and Biotechnology | 17-21 July 2017 | Singapore.
  • Prize Award | sbv IMPROVER Datathon | 23-24 Sep 2016 | Singapore.

Additional Information

  • Review Editor on the Editorial Board of Infectious Diseases: Pathogenesis and Therapy (specialty section of Frontiers in Medicine) | 2023 - present
  • Vice president | 2016-2017 | American Society for Microbiology, Student Chapter | NTU, Singapore.
  • Logistic Officer | 2014-2017 | Graduate Student Council | NTU, Singapore.
  • Assistant safety officer | 2016-2017 | Bioinformatics Institute A*STAR, Singapore.
  • Executive committee | 2012-2013 | Ethiopian Society of Tropical and Infectious Diseases, Ethiopia.
  • Secretary | 2011-2013 | Social and recreation committee, ALIPB, Addis Ababa University, Ethiopia.
  • Auditor | 2010-2012 | Adwa park condominium, Ethiopia.

List of Publications

https://orcid.org/0000-0002-6866-022X


1. Taye B, Thünauer R, Sugrue RJ, Maurer-Stroh S, Kosinski J. Identifying repurposed drugs with moderate
anti-influenza virus activity through computational prioritization of drug-target pairs. bioRxiv 2023.07.31.551116
2. Navaratnarajah CK, Pease DR, Halfmann P, Taye B, Barkhymer A, Howell KG, Charlesworth JE,
Christensen TA, Kawaoka Y, Cattaneo R, Schneider JW. Highly efficient SARS-CoV-2 infection of human
cardiomyocytes:spike protein-mediated cell fusion and its inhibition. Journal of virology 2021:JVI0136821.
3. Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, Tamirat M, Zewude A, Mohamed T, Medhin G,
Legesse M et al: Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non tuberculosis

mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation. Proteome science 2020, 18(1):10
4. Taye B, Chen H, Yeo DS, et al. A System Based-Approach to Examine Host Response during Infection with
Influenza A Virus Subtype H7N9 in Human and Avian Cells. Cells 2020; 9(2).
5. Malede A, Taye B, Legesse M, Debie A, Shibabaw A. Pulmonary tuberculosis preventive practices among
Anibessa Bus users at Addis Ababa, Ethiopia: a cross-sectional study. BMC research notes 2019; 12(1).
6. Berger KA, Pigott DM, Tomlinson F, et al. The Geographic Variation of Surveillance and Zoonotic Spillover
Potential of Influenza Viruses in Domestic Poultry and Swine. Open forum infectious diseases 2018; 5(12).
7. Taye B, Yeo D, Lee RTC, Tan BH, Sugrue RJ, Maurer-Stroh S. Inter-Species Host Gene Expression
Differences in Response to Human and Avian Influenza A Virus Strains. International journal of molecular
sciences
2017; 18(11).
8. Taye B, Vaz C, Tanavde V, et al. Benchmarking selected computational gene network growing tools in
context of virus-host interactions. Scientific reports 2017; 7(1): 5805.
9. Taye B, Chen H, Myaing MZ, Tan BH, Maurer-Stroh S, Sugrue RJ. Systems-based approach to examine the
cytokine responses in primary mouse lung macrophages infected with low pathogenic avian Influenza virus
circulating in South East Asia. BMC genomics 2017; 18(1): 420.
10. Tachbele E, Taye B, Tulu B, Ameni G. Treatment Outcomes of Tuberculosis Patients at Bale Robe Hospital
Oromia Regional State, Ethiopia: A Five Year Retrospective Study. Journal of Nursing & Care 2017; 06(02).
11. B Argaw D, Taye B, Worku A and Amare Worku. Major Risk Factors Predicting Anemia Development
during Pregnancy: Unmatched-Case Control Study. Journal of Community Medicine & Health Education 2015; 5: 353.

12. Tulu B, Dida N, Kassa Y, Taye B. Smear positive pulmonary tuberculosis and its risk factors among
tuberculosis suspect in South East Ethiopia; a hospital based cross-sectional study. BMC research notes 2014;7: 285.
13. Taye B, Desta K, Ejigu S, Dori GU. The magnitude and risk factors of intestinal parasitic infection in relation
to Human Immunodeficiency Virus infection and immune status, at ALERT Hospital, Addis Ababa,
Ethiopia. Parasitology international 2014; 63(3): 550-6.
14. Tesfaw L, Taye B, Alemu S, Alemayehu H, Sisay Z and Negussie H. Prevalence and antimicrobial resistance
profile of Salmonella isolates from dairy products in Addis Ababa, Ethiopia. African Journal of Microbiology
Research
2013; 7(43): 5046-50.
15. Taye B, Giday M, Animut A, Seid J. Antibacterial activities of selected medicinal plants in traditional
treatment of human wounds in Ethiopia. Asian Pacific journal of tropical biomedicine 2011; 1(5): 370-5.



Selected presentations

  • 41st annual meeting of the American Society for Virology | 16-20 July 2022 | Wisconsin-Madison
  • 17th annual IMV symposium, University of Minnesota | 9 June 2021| Virtual
  • Systems Biology: From large datasets to biological insight | 10 July 2019| Hinxton Cambridgeshire, UK.
  • 17th international congress of Virology | 17 - 21 July 2017 | Singapore.
  • Options IX for the control of Influenza | 24-28 Aug 2016 | Chicago, USA.
  • The 4th ISIRV-AVG conference | 2-4 June 2015 | University of Texas at Austin, USA.
  • International Conference on Bioinformatics (INCOB2016) | 21-23 Sept 2016| Singapore.
  • International meeting on respiratory pathogens (IMRP) |2-4 Sept 2015 | Singapore.
  • The 12th NUS-Nagasaki Joint symposium on Infectious Diseases |11-12 June 2015 | Singapore.
  • International Conference on Natural Products and Health | 5-7 Sept 2013 | NTU, Singapore.
  • More than 5 oral presentations in national scientific conferences | Ethiopia.

References

Jan Kosinski | Group leader at EMBL/CSSB | Tel: +49 (0) 40 8990 2787573 | email: jan.kosinski@embl.de


Sebastian Maurer-Stroh | Deputy Executive Director, BII A*STAR | email: sebastianms@bii.a-star.edu.sg


Abraham D Mengist | Assistant Professor, Nebraska Medical Center, USA | email: abraham.mengist@unmc.edu

Timeline

Research Fellow

Mayo Clinic
12.2020 - Current

Postdoctoral Fellow

European Molecular Biology Laboratory
04.2018 - 11.2020

Ph.D. - Bioinformatics

Nanyang Technological University/BII A*STAR
08.2013 - 01.2018

Assistant Professor/Lecturer

Addis Ababa University
12.2009 - 03.2018

Master of Science - Tropical And Infectious Diseases

Addis Ababa University
10.2007 - 07.2009

Bachelor of Science - Medical Laboratory Technology

Addis Ababa University
10.2004 - 08.2007

Medical Laboratory Technologist

ALERT Hospital
10.2002 - 12.2009

Diploma - Medical Laboratory Technology

Jimma University
09.2000 - 07.2002
Biruhalem Taye BeyeneBioinformatician/Infection Biologist/Medical Laboratory Scientist