Casey Chapman
Falls Church,VA
Summary
Determined and well-rounded individual with more than six years working as an Associate Scientist within the biotech industry. Able to manage multiple priorities to meet team goals. Primarily worked with AAV vectors for gene therapy products within the Potency Bioassay Analytical Development group.
Overview
7
7
years of professional experience
Work History
Associate Scientist III
RegenxBio
07.2017 - Current
- First started in the Quality Control group then switched to the Potency Bioassay group within the Analytical Development department in July, 2022.
- While in the QC group I managed internal and external contracted testing of GMP products ensuring timely release to support clinical programs.
- Managed the sample testing aspect, and data reporting of the GMP product stability program and numerous comparability studies.
- Conducted basic lab functions such as organizing lab testing data, making lab reagents/solutions, and coordinated other basic lab functions.
- Including the preparation and qualification of critical reagents.
- Coordinated testing, managed sampling, and data collection for numerous studies across multiple functional groups within AD/QC departments.
- Performed routine QC testing with various assays such as ELISA binding potency bioassay, Immunofluorescence potency bioassay, Immunostaining potency bioassay, DLS, and compendial assays (pH, Appearance and Osmolality).
- Performed routine potency testing with various methods to support process development and formulation groups.
- Performed ddPCR testing to support process development group.
- Trained on Analytical Ultra Centrifugation.
- Maintained cell cultures for method develop and routine testing as well as lead cell banking activities of primary cell lines (HEK-293, ARPE-19, HUH-7, HEP G2, SH-SY5Y, RD, U87-MG).
- Worked with standard T225/T75 flasks and hyperflasks.
- Extensive use of aseptic technique.
- Within the AD group I primarily worked with Scientists to develop, qualify, and validate cell-based analytical methods for measuring AAV-mediated transduction and biological activity of gene therapy products.
- Authored technical documents to support product release: Method validation protocols and reports, Technical reports for the qualification of reference standards, Qualification protocols and reports of primary/secondary reference standards, and Potency Method bridging reports.
- Participated in CMC activities to assist in improving product quality.
- Prepared and filled Reference Standards from tox reference standards to primary/secondary reference standards.
- Subject Matter Expert and Qualified Trainer of LabVantage LIMS and BioIT LIMS.
Education
M.S., in Pharmaceutical Sciences -
University of Florida
08.2020
B.S., Biology -
James Madison University
05.2016
Timeline
Associate Scientist III
RegenxBio
07.2017 - Current
M.S., in Pharmaceutical Sciences -
University of Florida
B.S., Biology -
James Madison University
Similar Profiles
Jenna LammersJenna Lammers
Independent Consultant at RegenxbioIndependent Consultant at Regenxbio
Darcy WeyantDarcy Weyant
Associate Director, Clinical Supply at REGENXBIOAssociate Director, Clinical Supply at REGENXBIO
Colin Bruce Jr.Colin Bruce Jr.
Cell Line Development Intern at RegenxbioCell Line Development Intern at Regenxbio
Karen HallKaren Hall
Assistant Director of Continuing Care – Nursing Home Administrator at Erickson LivingAssistant Director of Continuing Care – Nursing Home Administrator at Erickson Living
Emmanuel "Manoli" KarageorgosEmmanuel "Manoli" Karageorgos
Server at North ItaliaServer at North Italia