Charles A. Vecoli
Inlet Beach,FL
Summary
Dynamic executive with extensive experience in strategic portfolio management and program execution. Demonstrated leadership in integrating acquisitions and improving treatment options through innovative methodologies. Proven expertise in business acumen and critical thinking, achieving significant milestones in product development and global partnerships.
Overview
27
27
years of professional experience
Work History
Executive Director, Strategy Portfolio and Program Management
AstraZeneca Pharmaceuticals
Boston, MA
01.2024 - 10.2025
- Directed growing Therapeutic Area portfolio team for full life-cycle program management of Bone and Rare Endocrinology TA.
- Oversaw integration of Amolyt acquisition, doubling organizational size with the addition of two clinical-stage assets and one research-stage asset.
- Expanded partnerships with AstraZeneca business units, introducing new programs to the portfolio.
- Implemented Cell Therapy Platform utilizing CAR-T methodologies, enhancing treatment options.
- Developed and managed budgets supporting operational initiatives and key projects.
- Facilitated strategic planning sessions to establish organizational goals and objectives.
- Oversaw budget planning and resource allocation for various projects.
Sr. Director, Strategy, Portfolio, and Program Management Device Lead
AstraZeneca Pharmaceuticals
Barcelona, Spain
09.2022 - 12.2023
- Site development project manager, Barcelona, Rare Disease Division of AstraZeneca.
- Responsible for leading the Strategy, Portfolio, and Program Management team in the Bone and Rare Tumor TA.
- Hired, trained, and supported the staff for this TA in Barcelona, Spain.
- Held the role of Chief of Staff to the Barcelona Site Lead, TA Clinical Development Lead.
Device and Combination Product Lead
Alexion Pharmaceuticals, Inc.
04.2021 - 02.2022
- Responsible for leading key elements of the device operating model in alignment with Alexion’s Product to Patient business model and managing the respective program device strategy (planning, execution, and decision-making processes activities) within the Strategy, Program, and Portfolio Management (SPPM) team.
- Device and Applications Leadership Team (DALT) – supported the formation, chartering, and execution of the DALT.
- Defining the long-term enterprise platform strategy to ensure device recommendations are consistent across Alexion.
- Rare Disease Division of AstraZeneca
Director, Strategy, Portfolio, and Program Management
Alexion Pharmaceuticals, Inc.
08.2018 - 04.2021
- Global Program Management Lead ALXN1720 Program – provided program management leadership for the next-generation anti-C5 molecule development program.
- Led the transition from the pre-clinical to clinical phase, achieving First in Human in Sept. 2019.
- Continued program management of this clinical stage asset.
- Led R&D integration teams for two significant acquisitions.
- Lead the R&D integration teams for the integration of Achillion and Portola acquisitions.
- Provide Program Management leadership for the integration of the R&D assets for two major integrations.
- Transition company assets from Due Diligence phase into the integration execution phase pre- and post-close.
- Report out to senior leadership through the ISC and R&D governance models.
- Rare Disease Division of AstraZeneca
Independent Consultant
Principal Consultant
05.2017 - 08.2018
- Provide direct support and leadership on engagements for biopharma and medical device companies in need of product development, program management office (PMO) implementation, design history file/device manufacturing record remediation, and due diligence in drug master file remediation.
- Development of treatment delivery systems.
- Helping large and small companies achieve critical goals through better portfolio and program management practices.
- Self-employed
Sr. Director of Program and Portfolio Management, Oncology Division
Shire Pharmaceutical
Cambridge, MA
01.2015 - 05.2017
- Led a new team of Program Managers tasked with delivering Oncology portfolio development.
- Recruited and led team of PMs charged with internal developments, in-licensed products/assets, and partnerships.
- Managed a budget of >$120 Million annually, assembled and led a team of Project Managers driving global program execution.
- Achieved budget and milestone targets quarter over quarter.
- Led the Integration of the Pegylated-Asparaginase asset from Sigma Tau for the R&D function.
- Served as the R&D Integration lead on the Oncaspar integration.
- Executed an on-time full integration of the documentation supporting the Oncaspar product line, meeting all first-year launch commitments.
- Provided alliance management support to partnered companies.
- Led the strategic early development activities of option partnerships on the development of Allogeneic CAR-T and Checkpoint Inhibitor assets.
- Held role of Program Manager for the CAR-T program and provided management oversight for the checkpoint inhibitor program as part of the immune-oncology strategy.
- Formerly Baxalta
Sr. Director of Program Management, R&D Renal Division Medical Products
Baxter Healthcare, Inc.
Round Lake, IL
01.2011 - 01.2015
- Led a Global Program Management Office within the Renal business franchise.
- Led a team of nine direct reports who had oversight for a >$90 Million budget for new product development and life-cycle management of the renal product lines, including electromechanical devices, solutions and disposables.
- Managed the implementation of state-of-the art Program Management Systems including: project prioritization, Critical Chain Project Management, Financial-based project risk management utilizing RiskyProject software tools and Monte Carlo simulation, competency model development.
Director of Program Management, Infusion Pump Engineering
Baxter Healthcare, Inc.
01.2010 - 01.2011
- Led a cross-functional team with a $46.2 million budget in the application of design for six sigma (DFSS) methodologies to develop the next generation smart infusion pump system.
- Established the implementation of Critical Chain Project Management within the Infusion Pump Engineering Division’s next generation large volume infusion pump project.
Global Group Product Marketing Manager – Marketing GIS Division
Baxter Healthcare, Inc.
01.2007 - 01.2010
- Provided global leadership to the legacy large volume infusion pump business while the business pursued a remediation strategy for the COLLEAGUE large volume infusion pump in the US market.
- Resulting remediated design was returned to non-US market and with a significantly improved safety record.
- Design team consisted of US and India based resources from partner HCL.
- Led the Product Development Core Team to the successful launch of an interim release of the product outside the US.
- This included controlled launches and subsequent global launch activities.
- Established operating mechanisms for tracking current market sensitivities and developed communications between the regions and the Core Team regarding program status during development phases.
Business Marketing Manager – Gamma Knife Radiosurgery
Elekta, Inc.
Norcross, GA
01.2005 - 01.2007
- Led the successful North American launch of the Gamma Knife PerfexionTM stereotactic Radiosurgery system.
- Achieved 150% first year sales forecast.
- Developed the ‘Living With Brain Mets’ marketing campaign to demonstrate the clinical efficacy, financial utility, and market viability of using Gamma Knife for multiple brain metastases.
- Included a patient focused web campaign.
Director of Marketing – Radionics Division
Tyco Healthcare
Burlington, MA
01.2004 - 01.2005
- Developed brand identity for the X-Knife LINAC Radiosurgery System for Tyco.
- Led a team utilizing Concept Engineering Research in the development of the CUSA Excel ultra-sonic surgical aspirator, trans-sphrenoidal instruments and hand pieces for intracranial procedures.
- Achieved 25% growth in product line to $17 Million.
Vice President of Marketing
Photoelectron Corporation, Inc.
Lexington and N. Chelmsford, MA
01.1999 - 01.2004
- Held numerous executive leadership roles in start-up medical device company in sales (VP of Sales), marketing (VP of Marketing), and operations (VP of Operations) leading 35 direct reports.
- Led the strategic marketing, development, and launch of INTRABEAM miniature X-ray system for intra-operative radiation therapy.
- Steering committee member and program manager for the TARGiT Trial – Intraoperative radiation therapy for node-negative early stage breast cancer.
- Facilitated the Pediatric Ependymoma Brain Tumor Study at Memorial Children’s Hospital in Chicago, IL.
- At the request of Dr. Tadinori Tomita, organized a pediatric tumor consortium for the development of a protocol using INTRABEAM on pediatric Ependymoma after maximum course of external beam radiation.
Education
Bachelor of Science - Medicinal Chemistry
Providence College
Providence, RI05-1984
Bachelors of Science - Biology
Providence College
Providence, RI05-1984
Skills
- Leadership and strategy
- Critical thinking
- Business acumen
- Portfolio management
- Program and product management
- Global strategic partnerships
- Development lifecycle management
- Communication skills
Prior Experience
- Radionics Inc., Burlington, MA, Product Manager, Stereotactic Radiosurgery Products
- Scanalytics Division of CSPI, Billerica, MA, General Manager, Scientific Software Division
- ISS Enprotech (C. Itoh), Dedham, MA, Technology Director
Key Strengths Skills
- Leadership & Critical Thinking
- Strategy and Business Acumen
- Portfolio and Program Management
- Product Life-cycle Management
- Management of Global Strategic Partnerships
- Early, Clinical and Late-stage Development
- Excellent Communication Skills
Timeline
Executive Director, Strategy Portfolio and Program Management
AstraZeneca Pharmaceuticals
01.2024 - 10.2025
Sr. Director, Strategy, Portfolio, and Program Management Device Lead
AstraZeneca Pharmaceuticals
09.2022 - 12.2023
Device and Combination Product Lead
Alexion Pharmaceuticals, Inc.
04.2021 - 02.2022
Director, Strategy, Portfolio, and Program Management
Alexion Pharmaceuticals, Inc.
08.2018 - 04.2021
Independent Consultant
Principal Consultant
05.2017 - 08.2018
Sr. Director of Program and Portfolio Management, Oncology Division
Shire Pharmaceutical
01.2015 - 05.2017
Sr. Director of Program Management, R&D Renal Division Medical Products
Baxter Healthcare, Inc.
01.2011 - 01.2015
Director of Program Management, Infusion Pump Engineering
Baxter Healthcare, Inc.
01.2010 - 01.2011
Global Group Product Marketing Manager – Marketing GIS Division
Baxter Healthcare, Inc.
01.2007 - 01.2010
Business Marketing Manager – Gamma Knife Radiosurgery
Elekta, Inc.
01.2005 - 01.2007
Director of Marketing – Radionics Division
Tyco Healthcare
01.2004 - 01.2005
Vice President of Marketing
Photoelectron Corporation, Inc.
01.1999 - 01.2004
Bachelor of Science - Medicinal Chemistry
Providence College
Bachelors of Science - Biology
Providence College