CHRISTOPHER TRAVIS COTTAGE

Cell and molecular biologist with over 10 years of industry experience focusing on the mechanisms of cellular senescence and aging. Interdisciplinary scientist with a track record of leading a variety of projects with applications in respiratory, cardiovascular, and oncogenic drug development. A passionate communicator who thrives on building relationships and fostering collaboration to drive impactful outcomes and groundbreaking discoveries.

• Editor, Annals of Surgical Case Reports and Images, 2023-present
• Inamori Fellow, 2011 and 2012
• Rees-Stealy Research Fellow, 2010-2012
• Achievement Rewards for College Scientists (ARCS) Scholar, 2010-2012
• American Heart Association (AHA) Pre-Doctoral Fellowship, 2010-2012
• IRA Student Travel Fund Awards, 2008-2011
• Phi Kappa Phi Honor Society, 2008
• Harry E. Hamber Memorial Scholarship, 2008
• AHA Student Scholarship in Cardiovascular Disease and Stroke, 2008
• Howell-CSUPERB Student Research Fellow Award, 2006

• Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis., Radwanska A, Cottage CT, Piras A, Overed-Sayer C, Sihlbom C, Budida R, Wrench C, Connor J, Monkley S, Hazon P, Schluter H, Thomas MJ, Hogaboam CM, Murray LA., JCI Insight, 08/22/22, 7, 16, 10.1172/jci.insight.153058
• Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signaling., Ebeid DE, Khalafalla FG, Broughton KM, Monsanto MM, Esquer CY, Sacchi V, Hariharan N, Korski KI, Moshref M, Emathinger J, Cottage CT, Quijada PJ, Nguyen JH, Alvarez R, Völkers M, Konstandin MH, Wang BJ, Firouzi F, Navarrete JM, Gude NA, Goumans MJ, Sussman MA., Cardiovasc Res, 01/01/21, 117, 1, 201-211, 10.1093/cvr/cvaa066
• Targeting p16-induced Senescence Prevents Cigarette Smoke-Induced Pulmonary Emphysema by Promoting IGF1/Akt1 Signaling., Cottage CT, Peterson N, Kearley J, Berlin A, Xiong X, Huntley A, Zhao W, Criner GJ, Kolbeck R, Connor J, and Lemaire R., Nature Communications Biology, 2019, 10.1038/s42003-019-0532-1
• Pharamacodynamics of telomerase and telomere shortening by noncytotoxic suramin., Gan Y, Lu J, Yeung BZ, Cottage CT, Wientjes MG, Au J., AAPS J, 01/15, 17, 1, 268-76
• Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation., Din S, Mason M, Völkers M, Johnson B, Cottage CT, Wang Z, Joyo AY, Quijada P, Erhardt P, Magnuson NS, Konstandin MH, Sussman MA., Proc Natl Acad Sci U S A, 04/09/13, 110, 15, 5969-74
• Increased mitotic rate coincident with transient telomere lengthening resulting from Pim-1 overexpression in cardiac progenitor cells., Cottage CT, Neidig L, Sandararaman B, Din S., Joyo AY, Bailey B, Gude N, Hariharan N. Sussman MA., Stem Cells, 11/12, 30, 11, 2512-22, 10.1002/stem.1211
• Human Cardiac Progenitor Cells Engineered with Pim-1 Kinase Enhance Myocardial Repair., Mohsin S, Khan M, Toko H, Bailey B, Cottage CT, Wallach K, Nag D, Lee A, Siddiqi S, Lan F, Fischer K, Gude N, Quijada P, Avitabile D, Truffa S, Dembitsky W, Wu J, Sussman MA., J Am Coll Cardiol, 10/02/12, 60, 14, 1278-87, 10.1016/j.jacc.2012.04.047
• Asymmetric Chromatid Segregation in Cardiac Progenitor Cells Is Enhanced by Pim-1 Kinase., Sundararaman B, Avitabile D, Konstandin M, Cottage CT, Gude N, Sussman MA., Circ Research, 04/27/12, 110, 9, 1169-73
• Pim-1., Cottage C.T, Sundararaman B, Din S, Hariharan N, Sussman MA., Encyclopedia of Signaling Molecules, 2012, Springer Science, Book Chapter
• Myocardial AKT: The Omnipresent Nexus., Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin M, Malhowski A, Cheng Z, Khan M, McGregor M., Physiol Rev, 07/11, 91, 3
• Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin., Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Volkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R, Fischer K, Sussman MA., PNAS, 04/12/11, 108, 15, 6145-50
• Pim-1 Kinase Inhibits Pathological Injury by Promoting Cardioprotective Signaling., Fischer, KM, Cottage, CT, Konstandin, MH, Völkers, M, Khan, M, Sussman, MA., Journal of Molecular Cell Cardiology, 10/11, 51, 4, 554-8, 01/19/11
• Pim-1 kinase protects mitochondrial integrity in cardiomyocytes., Borillo GA, Mason, M, Quijada, P, Volkers M, Cottage, C.T., McGregor, M, Gude, N, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson, A, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA., Circ Res, 03/04/10
• Cardiac Progenitor Cell Cycling Stimulated by Pim-1 Kinase., Cottage C. T., Bailey B, Fischer KM, Avitabile D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA., Circ Res, 03/19/10, 106, 5, 891-901
• ΑMHC promoter can be used to engineer cardiac stem cells and cardiomyocyte progeny., Bailey B, Izarra A, Alavarez R, Fischer KM, Cottage C.T., Quijada P, Diez-Juan A, Sussman MA., Regenerative Medicine, 11/09, 4, 6, 823-33
• Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase., Fischer K, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA., Circulation, 11/24/09, 120, 21, 2077-87
• Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload., Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA., PNAS, 09/16/08, 105, 37, 13889 – 13894
• Activation of Notch-mediated protective signaling in the myocardium., Gude, N.A., Emmanuel, G.E, W. Wu, Cottage, C.T., Fischer K, Quijada P, Muraski Ja, Alvarez R, Rubio M, Schaefer E, Sussman Ma., Circulation Research, 05/08, 102, 1025-1035
• Evolution of the stem cell response to pathological challenge in the myocardium., Fransioli, J., Bailey, B., Gude, N.A., Cottage, C.T. Muraski J, Emmanuel G, Wu W, Alvarez R, Rubio M, Ottolenghi S, Schaefer E, Sussman MA., Stem Cells, 05/08, 26, 5, 1315 -1324
• Pim-1 regulates cardiomyocyte survival downstream of AKT., Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA., Nature Med, 12/07, 13, 12, 1467-75

• Disruption of P53/FOXO4 Interactions in Senescent Lung Cells Results in Senolysis., American Thoracic Society 2024 International Conference, 05/17-05/22/24, San Diego, CA
• Intratracheal Induction of Lung Senescence by Doxorubicin to Evaluate Senolytics., American Thoracic Society 2022 International Conference, San Francisco, CA
• Senolytic FOXO4 mimetic promotes alveolar tissue repair and restores lung function in COPD., Keystone Symposium, Fibrosis and Tissue Repair, 02/20, Victoria, British Columbia, Canada
• Senolytic FOXO4 mimetic peptides promote alveolar tissue repair and restore lung function in cigarette smoke-induced emphysema., Biopharmaceuticals R&D Global Science Symposium, 2019, Gothenburg, Sweden
• Regeneration and rejuvenation strategies for the treatment of respiratory diseases associated with accelerated aging including COPD., Canadian Respiratory Scientific Summit, 2018, Gaithersburg, Maryland
• Deletion of the p16 senescence pathway normalizes pulmonary function in cigarette smoke-Induced emphysema., 2018, San Diego, CA, American Thoracic Society
• Targeting cellular senescence prevents cigarette smoke-induced pulmonary emphysema., 2017, Gaithersburg, MD, Global Respiratory Leadership Forum
• Shelterin Complex Influenced by Pim-1 Preserves Telomeres in Cardiac Progenitor Cells., 11/13/10, Scientific Sessions American Heart Association, Chicago, IL
• Pim-1 activation modulates the shelterin complex resulting in lengthening and preservation of telomeres in cardiac progenitor cells and cardiomyocytes., 03/02/10, Keystone Basic Cardiovascular Research Conference, Keystone, CO
• Pim-1 activation lengthens and maintains telomeres in cardiac progenitor cells and cardiomyocytes., 07/09, AHA Basic Cardiovascular Sciences Conference, Las Vegas, NV
• Pim-1 Stimulates CPC Proliferation and Asymmetric Division., 11/08, E-Poster for American Heart Association Scientific Sessions Meeting, New Orleans, LA
• Pim-1 Stimulates CPC Proliferation and Asymmetric Division., 09/08, Stems of the Heart, Boston, MA