Dajun Chen

Seasoned, proactive and eager to learn synthetic organic chemist with success in medicinal and process chemistry objectives. Abreast of new synthetic methodologies; Adept in complex multi-step synthetic planning and execution; Adaptive to diverse reaction scales (mg to kg); Hand on experience of various purification and characterization techniques.

• Northeastern University, Boston, Massachusetts, 2/2007, 11/2008, Contributed the chemical method of protein-homocysteinylation detection by the synthesis of various aldehyde tags, co-authored paper on published on “Analytical Chemistry”.
• Colorado State University, 2003, 2004, Co-authored paper for J. Org. Chem.
• New Mexico State University, 2002, 2003, Co-authored paper for Chemical Communications.
• Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China, 2000, 2002, Papers published on “Org. Lett.” etc.

Title: Synthetic Organic Chemist

• In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6, Bioorganic Chemistry, 2024, Zdeněk Dvořák, Barbora Vyhlídalová, Petra Pečinková, Hao Li, Pavel Anzenbache, Alena Špičáková, Eva Anzenbacherová, Vimanda Chow, Jiabao Liu, Henry Krause, Derek Wilson, Tibor Berés, Petr Tarkowski, Dajun Chen, Sridhar Mani
• Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands, Advanced Synthesis & Catalysis, 2013, Carl A. Busaccal, Bo Qu, Nicole Grět, Keith R. Fandrick, Anjan K. Saha, Maurice Marsini, Diana Reeves, Nizar Haddad, Magnus Eriksson, Jiang-Ping Wu, Nelu Grinberg, Heewon Lee, Zhibin Li, Bruce Lu, Dajun Chen, Yaping Hong, Shengli Ma, Chris H. Senanayake
• Chemical Methods for the detection of Protein N-Homocysteinylation via Selective Reaction with Aldehydes, Anal. Chem., 2009, Tianzhu Zang, Shujia Dai, Dajun Chen, Bobby W. K. Lee, Suli Liu, Barry Karger, Zhaohui Sunny Zhou
• A diacetate ketone-catalyzed asymmetric epoxidation of olefins, J. Org. Chem., 2009, Bin Wang, Xin-Yan Wu, O. Andrea Wong, Brian Nettles, Mei-Xin Zhao, Dajun Chen, Yian Shi
• Palladium(0)-Catalyzed Cross-Coupling of Fluorous Bis(pinacolato)diboron: An Efficient Access to Fluorous Boronates, Synlett, 2005, Yangen Huang, Dajun Chen, Feng-ling Qing
• Synthesis of (pyridin-2-yl) hydrazine conjugates as bifunctional chelates using the Suzuki–Miyaura reaction, Chem. Commun., 2003, Jeffery B. Arterburn, BJ Bryant, Dajun Chen
• Preparation, properties and synthetic potentials of fluorous boronates, Tetrahedron, 2003, Yangen Huang, Dajun Chen, Feng-ling Qing
• Preparation, properties and synthetic potentials of boronates in a fluorous version (fluorous boronates), Organic Lett., 2002, Dajun Chen, Feng-ling Qing, Yangen Huang
• Regeneration of carbonyl function from carbonyl derivatives using polymer-supported phenyliodine bis (trifluoroacetate), Synth. Commun., 2001, Dajun Chen, Zhenchu Chen
• A new effective synthesis of Se-phenyl O, O-dialkyl phosphoroselenoate, Synth. Commun., 2001, Dajun Chen, Zhenchu Chen
• One-step conversion of aryl aldehydes to aroyl azides using a combined reagent of (diacetoxyiodo) benzene, Tetrahedron Lett., 2000, Dajun Chen, Zhenchu Chen
• A facile novel synthetic access to Se-phenyl O, O-dialkyl phosphoroselenoate, J. Chem. Res. (s), 2000, Dajun Chen, Zhenchu Chen
• Application of polymeric diaryliodonium salts as aryl transfer reagents in solid phase organic synthesis (SPOS), Synlett, 2000, Dajun Chen, Zhenchu Chen
• Synthesis of aryl esters of dithiocarbamic acids using polymeric diaryliodonium salts, J. Chem. Res. (s), 2000, Dajun Chen, Zhenchu Chen