David Lambe
Holliston,MA
Summary
Dynamic and results-oriented professional with over 20 years of experience in the pharmaceutical and biotech industries, specializing in finance, program and portfolio management, and Chief of Staff roles. Proven track record of driving cross-functional enterprise projects and executing strategic initiatives that significantly enhance organizational growth and efficiency.
Overview
2026
2026
years of professional experience
Work History
Senior Vice President, Portfolio Strategy & Operations
Harbinger Health
2023 - Current
- Member of the Executive Team, Lead Project Management Office
- Established and lead the PMO, crafting comprehensive end-to-end project plans for our lead diagnostic product from development to commercialization
- Formulated Corporate Goals for review and approval
- Initiated Governance meetings, standardizing decision-making processes
- Directly support the Office of the CEO, overseeing communications, leadership team meetings and off-sites
- Facilitate quarterly board meetings
- Manage “all employee” engagements and meetings
Executive Director, Business Operations
Alexion Rare Disease Unit
2021 - 2023
- Role focused on supporting the CEO of Alexion
- Facilitate and run all LT meetings including the Alexion leadership team (ALT), R&D LT, Commercial LT and Global Ops LT
- Integration Management Office Lead for Alexion
- Project Lead for Alexion for new building in Cambridge, MA
- Drive the creation of key annual deliverables - Alexion Strategy and Scorecard Goals
- Drive all CEO/Alexion Communications including townhalls, announcements etc
- Creating Alexion global location/hiring strategy across all functions (R&D, Commercial, G&A)
- Facilitate Alexion Senior Leader monthly meetings (VPs and above)
- Support Boston engagement team to facilitate on site events and culture efforts
Senior Director, Chief of Staff R&D
Alexion Pharma Inc.
2019 - 2021
- Role focused on supporting Head of R&D and his leadership team
- Facilitated and run all LT meetings including off-sites
- Drove all R&D Board of Directors deliverables/presentations
- Developed Annual R&D Goals
- Managed all Quarterly R&D townhalls and all R&D Communications/Announcements
- R&D Lead for AZ Acquisition
- Initiated 4 RDLT sub-teams focused on execution of the R&D Portfolio/goals, clarity on governance decisions, Financial performance and hiring/culture efforts
- Facilitate Guiding Star Awards and culture efforts for R&D
Director/Senior Director, R&D Portfolio Strategy Analysis and Operations
Alexion Pharma Inc.
2014 - 2019
- Member of the Portfolio Operations Team focused initiatives and solutions to inform R&D portfolio planning, investment & resource strategies and simplify decision making processes
- Delivery of key financial deliverables for R&D (Annual Op Plan & LRP)
- Led R&D Prioritization process
- Created resourcing & Portfolio modeling tools for Business Development, lifecycle investments, Research new targets demand, portfolio cycle times and success rates and Development resource demand model
- Developed Program and Study benchmarking (cycle times, success rates, costs)
- Enhanced Portfolio systems, data quality and reporting capabilities
- Drove Goals/objectives & Governance processes
Director, BU R&D Portfolio Operations
Pfizer, Inc.
2012 - 2014
- Established and tracked Milestone Goals and Project Objectives
- Led the Op Plan/Prioritization process to gain approval of the annual budget
- Managed authorized headcount targets for all functional lines
- Developed CRO change order tracking/status and approval process (eTemplate)
- Created program and study level benchmarking and metrics
- Led all R&D LT Operational Reviews (goals, objectives, dashboards and study performance metrics/issues)
- Implementation of Planisware planning and resource forecasting system (resource algorithms)
- Business Development lead for R&D development costs to support valuation analyses
- Led operational reviews with Partner Line functions to ensure alignment of resource efforts to Portfolio priorities
- Developed, automated and published numerous Portfolio Reports
Director, Primary Care R&D Finance
Pfizer, Inc.
2009 - 2012
- Primary Care Finance lead for Forecast, Op Plan and Long Range Forecast. Total budget for 2010 exceeded $1.69b
- Finance lead for Tanezumab program and Clinical function. Combined demand exceeded 21% of PC R&D budget
Associate Director, R&D Development Finance
Pfizer, Inc.
2006 - 2008
- Budgeting, reporting and analysis for the 12 Therapeutic Areas with a $1+ billion annual budget
Manager, R&D Finance
Pfizer Inc.
01.2004 - 01.2006
Senior Analyst, R&D Finance
Pfizer Inc.
01.2002 - 01.2004
Finance Analyst, Global Manufacturing
Pfizer Inc.
01.2000 - 01.2002
Budget Analyst, Finance
Partylite Inc.
01.1999 - 01.2000
“Maps” Implementation Project Team/Financial Analyst
Pfizer Inc.
01.1998 - 01.1999
Education
Master of Business Administration - Information Technology
University of Connecticut
Hartford, CT01.2005
Bachelor of Science - Business Management, Minor in Finance
Providence College
Providence, RI01.1998
Skills
- Governance & Decision-making
- Project management
- Strategy and goal setting
- Operations and Business management
- Program & Budget management
- Change management
- Financial reporting
- Corporate communications
- Cross Functional collaboration
- Process improvement
Timeline
Manager, R&D Finance
Pfizer Inc.
01.2004 - 01.2006
Senior Analyst, R&D Finance
Pfizer Inc.
01.2002 - 01.2004
Finance Analyst, Global Manufacturing
Pfizer Inc.
01.2000 - 01.2002
Budget Analyst, Finance
Partylite Inc.
01.1999 - 01.2000
“Maps” Implementation Project Team/Financial Analyst
Pfizer Inc.
01.1998 - 01.1999
Bachelor of Science - Business Management, Minor in Finance
Providence College
Senior Vice President, Portfolio Strategy & Operations
Harbinger Health
2023 - Current
Executive Director, Business Operations
Alexion Rare Disease Unit
2021 - 2023
Senior Director, Chief of Staff R&D
Alexion Pharma Inc.
2019 - 2021
Director/Senior Director, R&D Portfolio Strategy Analysis and Operations
Alexion Pharma Inc.
2014 - 2019
Director, BU R&D Portfolio Operations
Pfizer, Inc.
2012 - 2014
Director, Primary Care R&D Finance
Pfizer, Inc.
2009 - 2012
Associate Director, R&D Development Finance
Pfizer, Inc.
2006 - 2008
Master of Business Administration - Information Technology
University of Connecticut
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