Eric QIANG SHAO

Experienced neuroscientist with 13 years of research experience in industry and academia with expertise in Alzheimer’s disease, ALS, and Autism. Expertise spans from molecular, cell-based assay to animal behavioral, and electrophysiology techniques with extensive experience leading preclinical projects, collaborations, and research mentorships. Self-motivated researcher with demonstrated record of success in independent hypothesis generation, experimental validation, and critical interpretation of results, as evident in 11 first authored and 14 co-authored publications in high-impact journals. Led preclinical projects including collaborating with academic and industry partners to design and execute in vitro and in vivo assays to screen compounds and validate therapeutic targets for neurological diseases. Effective communicator and collaborator who excels in a fast-paced, team-based working environment.

• Member of the Alzheimer’s Association International Society to Advance Alzheimer Research and Treatment (ISTAART) (2019-)
• Member of the American Association for The Advancement of Science (AAAS) (2018-)
• Member of the Society for Neuroscience (2018-2023)
• Member of the American Heart Association (2017-)

• Junior postdoctoral fellows and research associates, 2019-2022
• Graduate students, 2019-2021
• Graduate students and master students, 2015-2019
• Undergraduate students, 2010-2015

• Reducing neural network dysfunction with Tau-targeting antisense oligonucleotides and defining therapeutic windows, Scientific Advisory Board Meeting, San Francisco, California, 2022
• Tau: a potential therapeutic target of autism spectrum disorders, Neuroscience seminar, San Francisco, California, 2022
• C9orf72-mediated Amyotrophic Lateral Sclerosis and Frontotemporal Dementia, Neuroscience seminar, San Francisco, California, 2020
• Inhibition of mTORC1 hyperactivation from impaired lysosomal degradation arrests immune dysfunction in C9orf72/Smcr8 mutant mice, Society for Neuroscience annual conference, San Diego, California, 2018

• 2021 Tau Consortium fellow
• 2020 Tau Consortium fellow
• 2017-2019 Reviewer for Scientific Reports and Plos One
• 2014 Scholarship for the outstanding scientific research
• 2013 Scholarship for the outstanding scientific research
• 2008 Excellent League Member of Shenyang Agricultural University

• TAU ablation in excitatory neurons and postnatal knockdown of brain TAU reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model, Science Translational Medicine, 10.1126/scitranslmed.abm5527, 2022
• Tau: enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies, Science, 10.1126/science.abb8255, 2021
• Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models, iScience, 10.1016/j.isci.2021.103245, 2021
• Phenotypic differences between the Alzheimer’s disease-related hAPP-J20 model and heterozygous Zbtb20 knock-out mice, eNeuro, 10.1523/ENEURO.0089-21.2021, 2021
• Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes, Genes & Development, 10.1101/gad.332494.119, 2020
• C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis, Autophagy, 10.1080/15548627.2019.1703353, 2019
• Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models, Human Molecular Genetics, 10.1093/hmg/ddz230, 2019
• Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice, Development, 10.1242/dev.173765, 2019
• C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner, Acta Neuropathologica Communication, 10.1186/s40478-019-0685-7, 2019
• Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors, Nature Communications, 10.1038/s41467-019-10497-2, 2019
• Mesenchyme Homeobox 1, a novel regulator in TGF-β-induced smooth muscle cell differentiation, Journal of biological chemistry, 10.1074/jbc.RA117.001578, 2018
• Brain cytoplasmic RNA 1 Negatively Regulates Smooth Muscle Differentiation and Vascular Development, Journal of biological chemistry, 10.1074/jbc.RA118.002350, 2018
• Establishing mouse models for Zika virus-induced Neurological Disorders using Intracerebral Injection strategies: embryonic, neonatal, and adult, Journal of Visualized Experiments (JoVE), 10.3791/56486, 2017
• The African Zika Virus is More Virulent and Causes More Severe Brain Damage Compared to the Asian Lineage and Dengue Virus, Development, 10.1242/dev.156752, 2017
• Immunomodulatory and anti-IBDV activities of the polysaccharide AEX from coccomyxa gloeobotrydiformis, Mar. Drugs, 10.3390/md15020036, 2017
• Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage, Development, 10.1242/dev.143768, 2016
• Expression of stem cell pluripotency factors during regeneration in the earthworm Eisenia foetida, Gene, 10.1016/j.gene.2015.10.058, 2016
• Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells, Virus Research, 10.1016/j.virusres.2014.12.019, 2015
• Pigeon RIG-I function in innate immunity against H9N2 IAV and IBDV, Viruses, 10.3390/v7072813, 2015
• Changes of CD4+CD25+ Cells Ratio in Immune Organs from Chickens Challenged with Infectious Bursal Disease Virus Strains with Varying Virulences, Viruses, 10.3390/v7031357, 2015
• Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells, Journal of general virology, 10.1099/vir.0.000277, 2014
• Specific inhibitory effect of κ-carrageenan polysaccharide on swine pandemic 2009 H1N1 influenza virus, PloS One, 10.1371/journal.pone.0126577, 2014
• A review of strategies for producing chimeric birds, Avian Biology Research, 2014
• Production of chimeras between the Chinese soft-shelled turtle and Peking duck through transfer of early blastoderm cells, Journal of Experimental Biology, 10.1242/jeb.083352, 2013
• Transgenic Quail Production by Microinjection of Lentiviral Vector into the Early Embryo Blood Vessels, PloS One, 10.1371/journal.pone.0056477, 2012