Summary
Overview
Work History
Education
Skills
Timeline
Generic

CHRISTOPHER GAUGHAN

North Brunswick,NJ

Summary

Python Developer specializing in Machine/Deep Learning, particularly as it applies to Image Classification and Robot Arm movement accuracy/precision. Specialty in Medical Imaging of critical anatomical structures for identification and subsequent delivery of accurate amounts of liquid (robotic instruments, cannula, needles) where viscosity must be accounted for. Highly skilled in computational methods and programming, robotics, algorithmic development, and data structures to refine code interacting with Convoluted Neural Networks to identify anatomical structures primarily via PyTorch and Tensorflow. Uses Python programming to develop robot arm precision of movement and injection of specific amounts of liquid via delivery devices as a function of viscosity and solution/mixture properties of liquid (critical because solutions and mixtures have different properties with respect to target delivery). PROFESSIONAL ACHIEVEMENTS Developed methods for preprocessing clinical images and analyzing targeted anatomical features using Deep Learning/ Convoluted Neural Networks methods to guide robotic manipulation of tools to interact with studied anatomical elements. Developed clinical imaging platforms with ultra-high sensitivity, high throughput, and automated data analysis generating decreased costs and time to production of prototypes. Prototype development of macromolecules, bioreactors, and robotic injection ports. Developed a lipid bi-layer model for use in Molecular Dynamic simulations, with the model featuring the exact lipid composition client needed for use in performing experiments in the mass transport of an anesthetic throughout a surgical site in the knee. Dedicated Bioengineering professional with a history of meeting company goals utilizing consistent and organized practices. Skilled in working under pressure and adapting to new situations and challenges to best enhance the organizational brand.

Overview

25
25
years of professional experience

Work History

VascuLogic - Principal Investigator

05.2010 - Current
  • Python Programming/ Training speed enhancement
  • Performs all pre-processing on clinically derived files (PET/CT/MR/X-ray-Images), preparation for convenient visualization
  • Employs Deep Learning/ ML to enhance accuracy of robot arm/syringe in targeting blood vessels and other anatomic features specified by operator
  • Performs coding for accurate volume delivery via robot arm/syringe
  • Performs calibration of robot syringe to deliver accurate volumes of liquid as a function of viscosity as well as solution/mixture nature.

Computational Biologist / Scientist / Programmer

LIVANDALA, INC
01.2019 - 01.2021
  • Leveraged AWS and Google Cloud Services to perform BioPython, PostgreSQL, and MySQL-based searches of genetic databases to find human genetic sequences that correspond to growth factors that may affect organogenesis and end-stage liver disease
  • Wrote NSF/XSEDE computational grants to space on large multi-cluster computational resources to carry out simulations that required multi-core (64-128) elements to enhance speed of molecular dynamics simulations on proteins of interest
  • Wrote Linux code to support such simulations
  • Used Python-based/Jupyter notebook tools to visualize data
  • Documented changes during experiments, noting unexpected issues arising during research activities
  • Consulted with researchers to analyze problems, recommend technology-based solutions, and determine computational strategies
  • Analyzed large molecular datasets such as raw microarray data, genomic sequence data or proteomics data for clinical or basic research purposes

Principal Investigator

BEAU RIDGE PHARMACEUTICALS
01.2018 - 01.2020
  • Created a computational model of nanoparticles with controlled release of bupivacaine to mitigate post-operative pain and swelling, a project that resulted in publication
  • Performed Computational Fluid Dynamics studies to determine the rate of nanoparticle release of various drugs that ranged in terms of hydrophobicity and nanoparticle pore-size

INDEPENDENT RESEARCH CONSULTANT - Protein Engineering Consultant

01.2015 - 01.2018
  • Performed Molecular Dynamics Simulations after docking a group of substrates with an enzyme active site using AMBER
  • Calculated thermodynamic parameters on XSEDE/NSF Supercomputer cluster
  • Carried out project management of several projects, including resource management and budget generation for reagents and equipment, as well as directing technical staff in meeting goals
  • One of lead scientists on team that developed a novel fluidized bed/CSTR bioreactor for expansion of stem cells.

Staff Scientist

ZYMERA, INC
01.2011 - 01.2015
  • Decreased annual licensing fees by $10,000 per gene by collaborating with the CMO to produce IP-free expression vectors and subsequent IP-free proteins
  • Streamlined protein chemistry such that target products were produced on order of days instead of months thus incurring significant savings in both time and budget
  • Designed and expressed novel tri-block protein: streptavidin-Renilla Luciferase-PerCp whose purpose was to bind to biotinylated targets and deliver long wavelength report with very high stokes shift to enable signal penetration through dense layers of tissue wile still being detectable in the Attomolar region.

Doctoral Fellow

MEDIMMUNE / ZYMERA, INC, National Science Institute Industrial Post
01.2011 - 01.2012
  • Selected for a post-doctoral fellowship at this cGMP-compliant facility to enhance vaccine production by strategizing and executing initial validation of an experimental, ultra-sensitive, high-throughput assay used in viral infection detection in VERO cells
  • Increased throughput of vaccine development platform by cross-functional collaboration on the troubleshooting and validation of a plaque-counting assay.

Education

Ph.D. - Chemical and Biochemical Engineering

RUTGERS UNIVERSITY
New Brunswick, NJ
10.2008

Bachelor of Science - Chemistry

SUNY UNIVERSITY At Albany
Albany, NY

Skills

  • TECHNICAL SKILLS & EXPERTISE
  • ENGINEERING/MATHEMATICS and COMPUTATIONAL BACKGROUND: Chemical Engineering, Linear Algebra, Statistics, Differential Equations, Protein Engineering, LINUX (Ubuntu, CSH/ Mac-Linux (XNU)), Python3, HTML, CSS, Discreet Mathematics
  • CLINICAL/ PHARMA: Development of clinical imaging sensors (quantum-dot based), Clinical diagnostics assay development, Fluorescent, and Bioluminescent clinical reagent development, Engineering of diagnostic protein and peptide reagents, Neuropharmacology/ Neurotoxicology
  • COMPUTATION TOOLS: Data Analysis/ Visualization, Python, Jupyter Notebooks, NumPy, Pandas, PyTorch, Scikit-Learn, Google Cloud Bioinformatics Workflows, Large Database Queries (PostgreSQL/MYSQL), Data Storage, Machine/Deep Learning
  • CLOUD TOOLS: AWS EC-2, S2, Google Cloud, Google Co-Lab, Google GPU engagement, NSF- Supercluster computational services and virtual machines, job-scheduling MPI-interface
  • Operational Efficiency
  • Investigative Procedures
  • Change Management Process
  • Computational modeling
  • Fundraising expertise
  • Modeling skills

Timeline

Computational Biologist / Scientist / Programmer

LIVANDALA, INC
01.2019 - 01.2021

Principal Investigator

BEAU RIDGE PHARMACEUTICALS
01.2018 - 01.2020

INDEPENDENT RESEARCH CONSULTANT - Protein Engineering Consultant

01.2015 - 01.2018

Staff Scientist

ZYMERA, INC
01.2011 - 01.2015

Doctoral Fellow

MEDIMMUNE / ZYMERA, INC, National Science Institute Industrial Post
01.2011 - 01.2012

VascuLogic - Principal Investigator

05.2010 - Current

Ph.D. - Chemical and Biochemical Engineering

RUTGERS UNIVERSITY

Bachelor of Science - Chemistry

SUNY UNIVERSITY At Albany
CHRISTOPHER GAUGHAN