Hoang Nguyen
Hayward,CA
Summary
Dynamic researcher experienced with supporting drug development from early discovery through clinical transition. Skilled in designing and executing in vivo studies to assess efficacy, safety, and PK/PD profiles, generating critical data that informs go/no-go decisions. Collaborated with multidisciplinary teams to advance multiple programs from preclinical research into the clinic, contributing to IND-enabling studies and regulatory filings.
Overview
8
8
years of professional experience
Work History
Associate Scientist
Denali Therapeutics
02.2022 - Current
- Researched and developed novel rodent techniques to advance scientific objectives
- Design and execute preclinical in vivo studies to support biomarker discovery and PK/PD analysis.
- Characterize neurodegenerative disease models (Parkinson’s, MPS, Gaucher’s) for drug development.
- Communicate study designs, findings, and biomarker data to cross-functional teams.
Research Scientist
Denali Therapeutics
South San Francisco
02.2017 - 02.2022
- Work with a diverse team across functions on programs to forward drug candidates with in vivo studies.
- Managed multiple projects simultaneously, demonstrating exceptional time management skills while maintaining high levels of accuracy.
- Trained new employees on vivarium procedures and wet lab techniques, ensuring compliance with protocols and best practices.
- Optimizing existing protocols to enhance efficiency and accuracy.
- Continuously assessed and refined methodologies to improve experimental processes and outcomes.
Study Technician Consultant
Denali Therapeutics
South San Francisco
01.2018 - 01.2019
- Conducted in vivo studies for pharmacokinetics, pharmacodynamics, efficacy, and safety assessment.
- Processed tissues and performed molecular assays for biomarker evaluation.
- Assisted with execution, and data analysis for in vivo research.
- Collaborated with cross-functional teams for seamless integration of input from various subject matter experts.
- Increased productivity by maintaining a clean, organized, and stocked work environment suitable for efficient study execution.
- Contributed to successful project completion by effectively collaborating with team members.
Undergraduate Researcher under Joanna Chiu
University of California, Davis
Davis
06.2017 - 06.2018
- Under mentorship, developed and performed individualized project characterizing the seasonal adaptation of the cuticular hydrocarbons of Drosophila suzukii
- Developed skills to work with both in vitro and in vivo techniques to assist in multiple programs for the lab
- Performed protein, DNA, RNA isolation from tissues and assess clock protein levels in brain
- Dissect out brains and ovaries of Drosophila melanogaster for Immuno-histochemistry
- Use aseptic technique to clone genetic material in plasmids and bacteria
- Used RNAi to knock out genes for characterization of flies
- Assessed mass spectroscopy data to differentiate cuticular hydrocarbons and the level of expression using heat maps (developed from R program)
Animal Care Technician Consultant
Denali Therapeutics
South San Francisco
01.2017 - 01.2018
- Worked in a team to develop and maintain the facility’s rodent database on Climb
- Maintained rodent colonies, followed microisolator technique and standard of care according to IACUC protocol
Education
Bachelor of Science - Animal Biology
University of California, Davis
Davis, CA05-2018
Skills
- Laboratory techniques (Western, qPCR, FACS/FLOW, MSD, ELISA)
- Microsoft, Prism, R Studio, Benchling, Colony Mangement Software
- Scientific writing
- Microscopy techniques
- Project management
- In vivo dosing techniques and rodent surgeries
Timeline
Associate Scientist
Denali Therapeutics
02.2022 - Current
Study Technician Consultant
Denali Therapeutics
01.2018 - 01.2019
Undergraduate Researcher under Joanna Chiu
University of California, Davis
06.2017 - 06.2018
Research Scientist
Denali Therapeutics
02.2017 - 02.2022
Animal Care Technician Consultant
Denali Therapeutics
01.2017 - 01.2018
Bachelor of Science - Animal Biology
University of California, Davis