Hyeonseo Cho
Boston,USA
Overview
7
7
years of professional experience
Work History
Research Technician
Dana Farber Cancer Institution
Boston, MA
07.2023 - Current
Collaborating with a postdoctoral fellow to investigate small cell lung cancer (SCLC) through in vivo and in vitro models.
An EED Lineage Plasticity Study
- Identified EED as a key epigenetic regulator of SCLC phenotype.
- worked on creating an SCLC transformation mouse model.
- Established cell lines from the mouse model and conducted an in vitro study.
- Investigated the mechanism of EED in maintaining the SCLC phenotype: EED as a repressive regulator of LUAD oncogenic RAS, PI3K, and MAPK pathway genes.
A PD-L1 immunotherapy efficacy study.
- Suggested the efficacy of combination therapy with PD-L1 and Aurora A kinase inhibitor for SCLC.
An LSD1 study.
- Investigating CoREST complex on maintaining neuroendocrine feature.
- Testing several drugs on SCLC neuroendocrine cell lines.
Research Intern
Dana Farber Cancer Institution
Boston, MA
01.2023 - 05.2023
Student
Boston Medical Center
Boston, MA
06.2022 - 07.2022
- Worked on Muscle Dystrophy at Boston Medical Center as a summer student.
Volunteer
Boston Medical Center
Boston, MA
01.2025 - Current
- Assisting patients in finding the location.
- Supporting patients at the Surgical Step Down Unit.
Volunteer
Mass General Hospital
Boston, MA
01.2022 - Current
- Transporting wheelchair patients when they are discharged.
- Adhering to organization procedures and instructions to maintain the safety of patients.
- Navigating patients and visitors at the Emergency Department.
Volunteer
National Sorok Island Hospital
, South Korea
05.2018 - 12.2019
- Provided support and companionship to patients with leprosy in need of assistance.
- Wheelchaired patients when they needed under the supervision of nurses.
Grader
Southern Utah University
Cedar City, UT
10.2018 - 04.2019
- Graded Calculus and Trigonometry class, and explaining correct solution.
Education
Bachelor of Arts - Biology
Boston University
Boston, MA01.2023
Southern Utah University
Cedar City, UT01.2019
Skills
Animal Models
- Mouse breeding
- Tumor monitoring
- Mouse dissection
- Transfection
Cell culture
- CRISPR/Cas9 editing
- Drug assays
Molecular Biology
- RT-qPCR
- RNA extraction
- Western blot
- Gateway cloning
- Immunoprecipitation
Software
- Image J
- GraphPad Prism
Community Service
- BU Student Ambassador Program, Alzheimer's Disease Research Center, Boston, MA, 10/2022, 04/2023, Participated in community outreach to encourage people to participate in the study., Learned about diverse communities and the importance of connecting with them., Attended lectures on Alzheimer's Disease pathology and various treatments helping patients., Learned how to develop rapport with patients with dementia.
- Volunteer, Boston Project Rebound Reentry Services, Boston, MA, 11/2023, Current, Welcoming people who are formerly incarcerated to our community., Writing minutes of the monthly board meeting., Taking clients' intakes for further services., Helping clients get clothes and food cards., Participating in several fairs.
- Volunteer, Multicultural Aids Coalition (MAC), Boston, MA, 01/2025, Current, Outreaching to homeless people in Nubian Square, informing them about the healthcare services at MAC., Assisting events at MAC when needed.
- Volunteer, Horizons for Homeless Children, Boston, MA, 10/2021, 12/2021, Provided care for pre-K to elementary homeless children., Engaged in various activities with children such as role-playing, drawing, building blocks etc.
- Volunteer, Onnuri Church, Woburn, MA, 09/2021, 08/2023, Led a small group of 1st grade and 3rd grade., Supported program leader by engaging, fun and smooth-running events by helping with organization and planning.
- Volunteer, Gyeongnam Welfare Institute For People With Disability, South Korea, 09/2020, 12/2020, Assisted teachers to help children with disability to participate in the program., Helped children with intellectual and physical disability to move and stretch their bodies., Enhanced their autonomy through hands-on activities such as cooking, coloring, and making products.
- Volunteer, Cedar City Library, Cedar City, UT, 04/2018, 04/2018, Read a Korean traditional book to elementary students by translating the book from Korean to English., Organized an origami activity during which children made a Korean traditional toy with Origami, and played games with the toy.
- Volunteer, Southern Utah University, Cedar City, UT, 03/2018, 03/2018, Cultural immersion trip to Salt Lake City., Distributed food in a food bank., Organized medical kits for those in need from various countries., Prepared food for homeless people.
- Volunteer, Canyon Home Care & Hospice, Cedar City, UT, 02/2019, 05/2019, 1 on 1 meeting with a patient once a week, establishing personal connection.
Publications
- Li Y, Mahadevan NR, Duplaquet L, Hong D, Durmaz YT, Jones KL, Cho H, Morrow M, Protti A, Poitras MJ, Springer BF, Bronson RT, Gong X, Hui YH, Du J, Southard J, Thai T, Li S, Lizotte PH, Gokhale PC, Nguyen QD, Oser MG. Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1. Cell Rep Med. 2023 Nov 21;4(11):101282. doi: 10.1016/j.xcrm.2023.101282. PMID: 37992688; PMCID: PMC10694667., Published
- Https://www.biorxiv.org/content/10.1101/2025.07.07.663486v1, Under review
Research
- Research Intern, Dana Farber Cancer Institution, Boston, MA, 01/2023, 05/2023, Matthew Oser M.D., Ph.D
- Research Technician, Dana Farber Cancer Institution, Boston, MA, 07/2023, Present, Matthew Oser M.D., Ph.D, Collaborated with postdoctoral fellow to investigate small cell lung cancer (SCLC) through in vivo and in vitro models., Identified EED as a key epigenetic regulator of SCLC phenotype., Worked on making an SCLC transformation mouse model., Established cell lines from the mouse model, and conducted an in vitro study., Investigated the mechanism of EED in maintaining SCLC phenotype - EED as a repressive regulator of LUAD oncogenic RAS, PI3K, and MAPK pathway genes., Suggested the efficacy of combination therapy with Aurora A kinase inhibitor for SCLC., Investigating CoREST complex on maintaining neuroendocrine feature., Testing several drugs on SCLC neuroendocrine cell lines.
- Student, Boston Medical Center, Boston, MA, 06/2022, 07/2022, Lan Zhou M.D., Ph.D, Worked on Muscle Dystrophy at Boston Medical Center as a summer student.
Languages
Korean
Native/ Bilingual
Timeline
Volunteer
Boston Medical Center
01.2025 - Current
Research Technician
Dana Farber Cancer Institution
07.2023 - Current
Research Intern
Dana Farber Cancer Institution
01.2023 - 05.2023
Student
Boston Medical Center
06.2022 - 07.2022
Volunteer
Mass General Hospital
01.2022 - Current
Grader
Southern Utah University
10.2018 - 04.2019
Volunteer
National Sorok Island Hospital
05.2018 - 12.2019
Bachelor of Arts - Biology
Boston University
Southern Utah University
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