James Amor Smith
Watkinsville,GA
Summary
Dedicated Life Scientist with more than 18 years experience in laboratory research and 6 years working in the pharmaceutical industry. Sharp and focused professional with exceptional communication and project management skills. Proven ability to handle multiple tasks effectively and efficiently toward optimizing processes and supporting team objectives.
Overview
16
16
years of professional experience
Work History
Senior Scientist, Bioprocesses Development
Boehringer-Ingelheim Animal Health USA Inc.
01.2022 - Current
- Provide early bioprocess expertise & technical leadership for late-stage research projects, managing smooth transitions into biological development & aligning with long-range objectives
- Independently Identify & implement new approaches, developing robust, scalable, & economical processes for biological products (vaccines, proteins, antibodies) utilizing platform technologies
- Coordinate collaboration, guiding experimental design, raw material use, & data/result analysis
- Aid in transfer & scale up of New Biological Entities from Development to Operations
Research/Senior Scientist, Asst. Dir. Purification & Process Development
Aalto Scientific, Ltd.
01.2019 - 01.2022
- Extracted & purified native enzymes from whole organ tissue & serum; scaled up processing
- Expressed & purified medically relevant human proteins in E. coli model systems; scaled up
- Created new lines of products & improved stability of existing products
- Directed a team of 8 & routinely advised on optimization of all aspects of product development
Research Technician I/II, Graduate Research Asst.
Complex Carbohydrate Research Center
06.2009 - 08.2018
- Offered individual training of biological & chemical procedures to students/personnel
- Utilized & maintained cutting edge instruments; UHPLC, LC-MS/MS, GC-MS, NMR, & MALDI-TOF
- Manipulated model organism cell walls through targeted gene editing
- Identified & characterized nucleotide-sugar biosynthesis enzymes & glycosyltransferases
- Isolated & characterized metabolites with unique molecular properties from plant, fungi, bacteria cell extracts & recombinant enzyme reactions by real-time NMR, HPLC, GC-MS, & LC-MS/MS
Education
BS - Biochemistry/Molecular Biology
University of Georgia
BS - Biology
University of Georgia
01.2008
PhD - Biochemistry/Molecular Biology
University of Georgia
01.2018
Skills
- Experimental design
- Assay development
- Project management
- Training and mentoring
Publications
- 1. James Amor Smith, Maor Bar-Peled. Identification of an apiosyltransferase in the plant pathogen Xanthomonas pisi. PLoS One. 2018. 13(10).
- 2. James Amor Smith, Maor Bar-Peled. Synthesis of UDP-apiose in Bacteria: The marine phototroph Geminicoccus roseus and the plant pathogen Xanthomonas pisi. PLoS One. 2017. 12(9).
- 3. James Amor Smith, et Al. Functional Characterization of UDP-apiose Synthases from Bryophytes and Green Algae Provides Insight into the Appearance of Apiose-containing Glycans during Plant Evolution. J Biol Chem. 2016. Oct 7; 291(41).
- 4. Jonathan D. Willis, James Amor Smith, et Al. Downregulation of a UDP-Arabinomutase Gene in Switchgrass (Panicum virgatum L.) Results in Increased Cell Wall Lignin While Reducing Arabinose-Glycans. Front Plant Sci. 2016. 7: 1580.
- 5. Viviana Martinez, Miles Ingwers, James Amor Smith, John Glushka, Ting Yang, Maor Bar-Peled. Biosynthesis of UDP-4-keto-6-deoxyglucose and UDP-rhamnose in Pathogenic Fungi Magnaporthe grisea and Botryotinia fuckeliana. J Biol Chem. 2012. Jan 6; 287(2): 879–892.
- 6. Ting Yang, Yael Bar-Peled, James Amor Smith, John Glushka, Maor Bar-Peled. In-microbe formation of nucleotide sugars in engineered Escherichia coli. Anal Biochem. 2012. Feb 15;421(2):691-8.
- 7. Xiaogang Gu, John Glushka, Yanbin Yin, Ying Xu, Timothy Denny, James Amor Smith, Yingnan Jiang, Maor Bar-Peled. Identification of a Bifunctional UDP-4-keto-pentose/UDP-xylose Synthase in the Plant Pathogenic Bacterium Ralstonia solanacearum. J Biol Chem. 2010 Mar 19; 285(12): 9030-9040.
Timeline
Senior Scientist, Bioprocesses Development
Boehringer-Ingelheim Animal Health USA Inc.
01.2022 - Current
Research/Senior Scientist, Asst. Dir. Purification & Process Development
Aalto Scientific, Ltd.
01.2019 - 01.2022
Research Technician I/II, Graduate Research Asst.
Complex Carbohydrate Research Center
06.2009 - 08.2018
BS - Biology
University of Georgia
BS - Biochemistry/Molecular Biology
University of Georgia
PhD - Biochemistry/Molecular Biology
University of Georgia
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