Jaspreet Kalra

Highly skilled scientist with expertise in rodent behavior, mammalian cell culture, literature search, scientific editing, proofreading, summarizing, report writing, and microbiological techniques. Proficient in molecular biology techniques such as RT-PCR, immunofluorescence technique, gel electrophoresis, western blotting, ELISA, protein purification, and protein-protein interactions. Experienced with non-invasive blood pressure systems, isometric tension studies (AD Instruments), confocal laser scanning microscope (Leica DMi8), FT-IR (JASCO), microplate reader (Spectra max), UV-VIS spectrophotometer, and Flow cytometer. Motivated with a strong work ethic and punctuality, utilizing organizational skills and team collaboration to enhance processes.

• 01/01/23 - 06/30/25, American Heart Association-Postdoctoral Fellowship
• 05/01/19 - 02/29/20, CSIR-Ministry of Human Resource Development (MHRD), Govt of India. CSIR-SRF fellowship for pursuing doctoral research
• 03/01/20, DST-International travel grant, Ministry of Science and Technology, India

• Kalra J, Artamonov M, Wang H, Franke A, Markowska Z, Jin L, Derewenda ZS, Ayon R, Somlyo A. p90RSK2, a new MLCK, rescues contractility in myosin light chain kinase null smooth muscle. bioRxiv [Preprint]. 2023 May 22:2023.05.22.541840. doi: 10.1101/2023.05.22.541840. Update in: Front Physiol. 2023 Sep 13;14:1228488. doi: 10.3389/fphys.2023.1228488. PMID: 37292593; PMCID: PMC10245941.
• Kalra J. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res. 2023 Jan;18(1):94-101. doi: 10.4103/1673-5374.343884. PMID: 35799515; PMCID: PMC9241418.
• BollaReddy SVR, Krishna V, Kalra J, Goyal SG, Dhar A, Bhat A. Review of Contemporary Coronary Artery Stents and Future Developments. Research Reports.
• Udumula MP, Mangali S, Kalra J, Dasari D, Goyal S, Krishna V, Bollareddy SR, Sriram D, Dhar A, Bhat A. High fructose and streptozotocin induced diabetic impairments are mitigated by Indirubin-3-hydrazone via downregulation of PKR pathway in Wistar rats. Sci Rep. 2021 Jun 21;11(1):12924. doi: 10.1038/s41598-021-92345-2. Erratum in: Sci Rep. 2021 Aug 19;11(1):17152. PMID: 34155273; PMCID: PMC8217483.
• Kalra J, Bhat A, Jadhav KB, Dhar A. Up-regulation of PKR pathway contributes to L-NAME induced hypertension and renal damage. Heliyon. 2020 Nov 18;6(11):e05463. doi: 10.1016/j.heliyon.2020.e05463. PMID: 33294654; PMCID: PMC7689172.
• Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB, Dhar A. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sci. 2020 Dec 1;262:118436. doi: 10.1016/j.lfs.2020.118436. Epub 2020 Sep 17. PMID: 32950570.
• Kalra J, Mangali S, Bhat A, Jadhav K, Dhar A. Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165606. doi: 10.1016/j.bbadis.2019.165606. Epub 2019 Nov 15. PMID: 31740405.
• Kalra J, Mangali SB, Dasari D, Bhat A, Goyal S, Dhar I, Sriram D, Dhar A. SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy. Fundam Clin Pharmacol. 2020 Apr;34(2):173-188. doi: 10.1111/fcp.12516. Epub 2019 Nov 19. PMID: 31698522.
• Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Vamsi Krishna Venuganti V, Dhar A. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochem Pharmacol. 2020 Jul;177:113948. doi: 10.1016/j.bcp.2020.113948. Epub 2020 Apr 3. PMID: 32251680.
• Kalra J, Mangali SB, Bhat A, Dhar I, Udumula MP, Dhar A. Imoxin attenuates high fructose-induced oxidative stress and apoptosis in renal epithelial cells via downregulation of protein kinase R pathway. Fundam Clin Pharmacol. 2018 Jun;32(3):297-305. doi: 10.1111/fcp.12352. Epub 2018 Mar 13. PMID: 29430716.
• Udumula MP, Bhat A, Mangali S, Kalra J, Dhar I, Sriram D, Dhar A. Pharmacological evaluation of novel PKR inhibitor indirubin-3-hydrazone in-vitro in cardiac myocytes and in-vivo in wistar rats. Life Sci. 2018 Sep 15;209:85-96. doi: 10.1016/j.lfs.2018.07.055. Epub 2018 Aug 1. PMID: 30076923.
• Kalra J, Lingaraju MC, Mathesh K, Kumar D, Parida S, Singh TU, Sharma AK, Kumar D, Tandan SK. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar;391(3):285-297. doi: 10.1007/s00210-017-1455-3. Epub 2017 Dec 26. PMID: 29279966.
• Kalra J, Dhar A. Double-stranded RNA-dependent protein kinase signalling and paradigms of cardiometabolic syndrome. Fundam Clin Pharmacol. 2017 Jun;31(3):265-279. doi: 10.1111/fcp.12261. Epub 2017 Mar 13. PMID: 27992964.

• First Ph.D graduate at BITS-Pilani Hyderabad, India to secure top percentile with CG 10 during the Ph.D course.
• Outstanding oral presenter at Global Health summit: ICONICA 2020 at Panjab University Chandigarh, from 02/12/20 - 02/14/20, among 79 oral presentations.
• Received a certificate of excellence in academics from Hindi Vyavahar Sangadhan and Rotary Club of Bareilly South.
• Recipient of Smt Usha Rani cash award and certificate for excelling in high school exams.
• IIIrd position in the quiz competition during National Technology Day Convention-2012 on Recent Advances in Pharmaceutical Technology held at ISF college of Pharmacy, Moga, Punjab, India. 08/01/12

Phytotherapy Research

▪ Molecular Medicine

▪ BMC Nephrology

▪ Scientific Reports

▪ Neural Regeneration Research

▪ Journal of Physiology and Medicine

▪ Molecular Medicine

▪ Neurochemistry International

▪ Neuroscience Letters

• UCSF Health
• University of Virginia