Jiyuan Zhang
Carrollton,TX
Summary
Experienced scientist with over 10 years of expertise in biochemistry, and protein sciences, specializing in therapeutic proteins and protein-ligand interactions. Proven leadership in protein biochemistry projects, with strong skills in protein purification, characterization, and engineering. Demonstrated ability to collaborate with interdisciplinary teams to drive innovation in therapeutic development.
Overview
11
11
years of professional experience
Work History
Assistant Professor
UT Southwestern Medical Center
Dallas, TX
01.2023 - Current
- Led research on lysosomal membrane-associated proteins
- Led discovery and characterization projects enhancing therapeutic reagent development
- Implemented high-throughput purification strategies improving protein production efficiency
- Enhanced cross-functional collaboration, boosting project team productivity.
Instructor
UT Southwestern Medical Center
Dallas, TX
01.2020 - 01.2023
- Led research on lysosomal membrane-associated proteins
- Led discovery and characterization projects enhancing therapeutic reagent development
- Implemented high-throughput purification strategies improving protein production efficiency
- Enhanced cross-functional collaboration, boosting project team productivity.
Research Investigator
UT MD Anderson Cancer Center
Houston, TX
01.2018 - 01.2020
- Advanced understanding of lysosomal calcium release mechanisms
- Optimized protein characterization methods, aiding biologics development.
Postdoc Fellow
UT MD Anderson Cancer Center
Houston, TX
01.2013 - 01.2018
- Advanced understanding of lysosomal calcium release mechanisms
- Optimized protein characterization methods, aiding biologics development.
Education
Ph.D. - Genetics and Biochemistry
China Agricultural University & Chinese Academy of Sciences
01.2012
B.S. - Biological Engineering
Chongqing University
01.2003
Skills
- Protein Biochemistry: Expert in protein purification, characterization, and engineering
- Protein Characterization: Proficient in various analytical methods
- Molecular Biology & Genetics: Skilled in genetic manipulation and analysis
- Data Analysis & Software: Competent in data processing with R and familiar with standard software
Affiliations
Active member of professional societies and participant in industry conferences, engaging with developments in protein sciences.
Publications
- Zhang, J., W. Zeng, Y. Han, W. R. Lee, J. Liou and Y. Jiang (2023). "Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel." Mol Cell 83(14): 2524-2539 e2527.
- Zhang, J., X. Guan, K. Shah and J. Yan (2021). "Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles." Nat Commun 12(1): 4739.
- Zhang, J., X. Guan, Q. Li, A. L. Meredith, H. L. Pan HL and J. Yan (2018). "Glutamate-activated BK channel complexes formed with NMDA receptors." Proc Natl Acad Sci U S A 115(38): E9006-E9014.
Timeline
Assistant Professor
UT Southwestern Medical Center
01.2023 - Current
Instructor
UT Southwestern Medical Center
01.2020 - 01.2023
Research Investigator
UT MD Anderson Cancer Center
01.2018 - 01.2020
Postdoc Fellow
UT MD Anderson Cancer Center
01.2013 - 01.2018
Ph.D. - Genetics and Biochemistry
China Agricultural University & Chinese Academy of Sciences
B.S. - Biological Engineering
Chongqing University