JONATHAN ACOSTA, MPH, MS

Department of Medicine, Clinical Trials Division

• Provided quality assurance–focused regulatory and operational oversight for the MCTO cellular therapy portfolio.
• Led QA oversight for CAR-T and advanced therapy trials using surveillance-based, population-level approaches to monitor protocol adherence, data quality, and patient safety.
• Managed and supervised a team of 6 research staff, delivering clinically informed QA training, workflow standardization, and performance oversight.
• Applied clinical judgment and epidemiologic methods to identify trends, deviations, and operational risk across studies, translating findings into corrective and preventive actions.
• Developed QA dashboards and longitudinal tracking systems to support audit readiness, safety monitoring, and continuous quality improvement.

Department of Medicine, Clinical Trials Division

• Coordinate and monitor clinical trials in CAR-T therapies, investigational drugs, and medical devices across liver, nephrology, and rheumatology specialties.
• Conduct ongoing trial monitoring visits and quality checks to ensure data accuracy, regulatory compliance, and patient safety.
• Lead data cleaning, query resolution, and database review activities to ensure complete and audit-ready study data.
• Collaborate with external vendors and EDC teams (RAVE, Veeva, Suvoda, OnCore) to test, validate, and maintain study databases.
• Contribute to development and refinement of data management SOPs, data dictionaries, and CRF specifications.
• Integrate clinical assessment and epidemiologic analysis to strengthen study outcomes.
• Exceeded enrollment goals by 15%, screen failures reduced by 10%, visit-related errors reduced by 39%.
• Ensure protocol compliance and generate high-quality datasets for population-level and clinical outcome evaluation.

Department of Emergency Medicine – Clinical Trials Division

• Oversaw all clinical trial research referrals, with 79% leading to successful randomization.
• Assisted with trial monitoring activities, including regulatory file reviews, source documentation checks, and visit readiness assessments.
• Coordinated patient support and maintained protocol binders, SOPs, and regulatory documentation to ensure compliance.
• Conducted staff training, refined admission workflows, and contributed to departmental performance metrics.
• Supported patient care through sample collection and direct clinical observation.
• Collaborated with physicians to perform patient assessments, interpret diagnostic data, and support accurate medical decision making.
• Integrated disease surveillance protocols to track outcomes, identify emerging trends, and inform evidence-based interventions enhancing patient safety and continuity of care.

Department of Infectious Disease – Peter Kruger Clinic

• Conducted cohort monitoring and coordinated care for 100+ patients in a primary care setting under an NIH-funded Care Coordination Research Program.
• Supported trial and data monitoring processes to ensure adherence to NIH and IRB standards.
• Collected and analyzed adherence data to evaluate intervention effectiveness and ensure protocol compliance.
• Designed and implemented a CQI project using the PDSA model, leading to 63% of patients achieving undetectable viral loads within 6 months (vs. 8-month benchmark).
• Collaborated interdepartmentally with physicians, nurses, case managers, and data teams to support accurate diagnosis, treatment planning, and continuity of care.
• Applied epidemiologic and disease surveillance methods to identify adherence trends, detect care gaps, and improve patient outcomes.

• Department of Urgent Care Medicine
• Documented clinical data for thousands of patient encounters in a high-volume urgent care setting.
• Assisted providers, reducing diagnostic errors by 20% and patient wait times by 15%.
• Ensured accurate EMR documentation and coding across multiple sites.
• Trained and supervised new scribes, optimizing workflows that increased provider productivity by 25%.
• Contributed to a 30% rise in patient volume through efficiency and improved satisfaction.
• Supported patient evaluation, triage, and evidence-based decision-making.
• Collaborated with providers to strengthen continuity of care and improve outcomes through real-time data tracking and disease trend analysis.