Jua Kim

• Highly motivated postdoctoral research scholar with 12 years (2010-2022) of academic and research experience.
• Documented publication record in peer-reviewed literature, such as Acta Biomaterialia, ACS Applied Materials & Interfaces, Journal of Arthroplasty, and Journal of Biomedical Materials Research Part A and B.
• Research interests are: 1) biomaterials, 2) metals, 3) biodegradable metals, 4) magnesium and magnesium alloys, 5) metal corrosion, 6) cytotoxicity, 7) tissue engineering, 8) animal studies, 9) metal-cell/metal-biomolecule interactions, 10) orthopedic device-related infections (i.e., biofilms), 11) cancer/stem cell research.
• Extensive experience in electrochemical and mechanical testing of metal alloys, performance testing, and failure & retrieval analysis of medical implants, and a variety of cell culture techniques.
• Proficient in conducting laboratory experiments while informing new hires on research methods and data collection procedures. Hardworking and driven with superior organizational and analytical skills combined with unparalleled dedication to research excellence. Skilled in conceptualization, design, and implementation of various research projects.
• Able to design, plan, and execute research experiments, analyze data, and write experimental plans/protocols, research proposals, scientific research papers, review papers, and grants.
• Knowledgeable in FDA regulations and ASTM standards for medical devices.
• Proficient in oral and written communication skills. Native in both English and Korean.
• Hardworking and driven to work quickly and effectively on projects in all types of environments.
• Able to collaborate and work well as a team. Can work independently as well.
• Have strong leadership skills.

• Full Name: Jua Kim (English Name: Jacelyn)
• Date of Birth: May 17th, 1987
• Citizenship: Republic of Korea
• Current Job Position: Postdoc Research Scholar at Shenzhen Institute of Advanced Technology (SIAT) Chinese Academy of Sciences (CAS), Shenzhen, Guangdong Province, 518055, China
• Google Scholar: https://scholar.google.com/citations?user=LikclhsAAAAJ&hl=en&oi=ao
• ORCID ID: 0000-0002-3949-9019
• Scopus Author Identifier: 56996865300

Postdoc Research Scholar at Shenzhen Institute of Advanced Technology (March 2021-Present), Shenzhen, Guangdong Province, China

• Continue previous Ph.D. work and research on pure Mg/Mg-Ti for their therapeutical potential for cancer and biofilm therapy.
• Develop novel Mg-B alloy as a bone regenerating material.
• Investigate metal-cell/metal-biomolecule interaction to understand how cells affect metal corrosion and how metal corrosion affects biology. Focused on metals in the bone microenvironment. Interested in metals interacting with osteoblasts, osteoclasts, mesenchymal stem cells, endothelial cells (related to angiogenesis), and immune cells like macrophages and neutrophils.
• Worked with human umbilical cord-mesenchymal stem cells (HUC-MSCs) and investigated cell stemness and cell proliferation rate under different oxygen levels (normal 21% O2 or hypoxia 2% O2) and media (DMEM + 10% FBS + 1% PSG, DMEM + 5% hPL + 1% PSG, or DMEM + 2% hPL + 1% PSG).
• Passed the initial postdoc evaluation on May 19th of 2021.
• Passed the mid-evaluation on December 11th of 2021.

Marketing/Sales/R&D Director at Global Works Company (July 2020-October 2020), Seoul, South Korea

• As a research director, designed and developed a research and development department at Global Works Company.
• Started research on a material called ABPM (which stands for Anti-Bacterial Porosity Minerals), mainly focused on its antibacterial effects and mechanism. Started to develop a color-changing ABPM using halochromic substances, so that ABPM can change color based on pH changes. The idea was based on the fact that bacterial growth causes acidification and lowers pH slightly to 6.8 or lower. Succeeded in developing color-changing ABPM that changes color to yellow when bacteria contaminate ABPM and then turns back to purple when bacteria is killed by ABPM (within minutes).
• Participated in developing ABPM's application on different products, such as cellphone cases (collaborating with TaeYang I.S.), air-conditioning filters (collaborating with Sang-A-Frontec), doctor/lab gowns, patient clothes, pajamas for atopy patients, various pet products, etc. All these items were manufactured by incorporating ABPM to give antibacterial properties. For example, incorporating ABPM on cotton by dipping or silk printing produced "ant-bacterial" cloth, which can kill 99.9% of bacteria when it contaminates the cloth. Such cloth is useful in producing special doctor or lab gowns or patient clothes, which are prone to germ contamination in hospital environment.
• Signed a non-disclosure agreement (NDA) and material transfer agreement (MTA) with Clemson University (South Carolina, USA) in order to collaborate in research on ABPM and its potential use on medical devices (e.g., bandages or surgical materials).
• As a marketing and sales director, sold COVID-19 products, such as hand sanitizers, masks, gloves, disinfectant sprays, and other antibacterial products.
• Searched for potential global buyers or distributors through various online platforms, such as go4worldbusiness, exporthub, tradewheel, globalsources, kompass, amazon, alibaba, ecplaza, ec21, etc. and talked to them via phone or online.
• Succeeded in signing a contract with Hanmi Pharmaceutical to distribute our products to pharmacies in Korea.
• Succeeded in signing an exclusive distributor agreement with Abhay Raj International located in India.
• Wrote all relevant forms and contracts, such as buyer product request form, proforma invoice, offer sheet, exclusive distributor application forms, exclusive distributor agreement, etc.
• Managed all company employees and led all internal company meetings.
• Built company website www.gwc.or.kr.

Founder and CEO at Novelis Corporation (July 2019-October 2020), Seosan, South Korea

• Helped clients with their imports and exports among the USA, China, and South Korea.
• Due to the COVID-19 pandemic, Novelis imported mask materials and mask-making machines from China and sold them to mask factories in Korea.
• Distributed KF-94 masks, dental masks, PPE, nitrile gloves, and other sanitary materials in the Korean market.

Expert Reviewer at Insilica LLC (January 2018-January 2019) Baltimore, MD

General Job Descriptions:

• Participated in the design and development of Sysrev (https://sysrev.com/), a unique platform that helps users build systematic reviews/literature reviews using the web application and machine learning tools.
• As an expert reviewer, helped clients with their projects in extracting, analyzing data, and writing.
• Wrote grants, publications, and systematic reviews.

Project Title: Natural Products for Prostate Cancer Therapy

• Investigated and wrote a systematic review on the following natural products: carotenoids (lycopene, alpha-carotene, and beta-carotene), vitamin E (alpha-tocopherol, beta-tocopherol, gamma-tocopherol), selenium, selenium + vitamin E, and their effects on prostate cancer incidence, prostate cancer-related mortality, and their potential mechanisms.

Project Title: Undiscovered Genes in Cancer Mechanisms

• Annotation-based pathway analysis is critical for understanding molecular pathways, but the selection process for gene annotation may be incomplete or biased. This study used differentially expressed genes across colon cancer clinical endpoints to prove this hypothesis. We gave "aggression" scores for genes from 6 phenotypic types: binary metastasis, percent positive lymph nodes, binary stage, lymphatic invasion, vascular invasion, and histology. Many genes had less than 20 publications and more than one-third of genes lacked annotations. However, there was no correlation between the "aggression" scores of genes and the number of annotations, meaning that many genes, that can be important in tumor progression, were under-annotated, meaning not studied extensively on their roles in cancer. Additionally, "orphan" genes that lack homologs were under-annotated more often than genes that had homologs. The number of annotations and publications of a gene increased as the number of homologs increased. This demonstrated that gene annotation analyses are biased towards genes with homologs.

Non-Matriculating Research Trainee at Kennedy Krieger Institute, Johns Hopkins University (February 2018-January 2019) Baltimore, MD

Project Title: TET1 Expression and Its Application in Developing Therapies for Treating Gliomas

• Wrote a systematic review for identifying genes and molecular pathways in glioblastoma to predict patient survival and therapeutic responses.
• Helped fulfill aims in ICI-Grant, titled "TET1 Expression and Its Application in Developing Therapies for Treating Gliomas". The hypothesis of this grant was that TET1 is a tumor suppressor gene known to have a strong relationship to tumor progression and tumor survival because TET1 is involved in DNA damage repair, suppression of metalloproteinases, etc. Therefore, identifying TET-1-related molecular features was important in understanding glioma and its progression. So, the overall goal of this project was to identify relationships between TET1 and genomic stability + patient survival in glioma. The specific aims were 1) Identify TET-1 related molecular features, 2) Model patient survival and genomic stability based on these features, 3) Interrogate survival functions for mechanistic properties.

Research Assistant, Ph.D. at Syracuse University (November 2011-May 2017) Syracuse NY

Dissertation Title: Cytotoxicity of Galvanically Coupled Magnesium and Titanium Particles for Therapeutic Effect

Patent Title: Biochemical Coupling of Metallic Biomaterial Implants for Biological Effect

Patent ID: US9039764B2

https://patents.google.com/patent/US9039764B2/en

• Investigated the cytotoxicity of galvanically-coupled magnesium-titanium microparticles due to electrochemical reactions on different cell types (Escherichia Coli, human osteosarcoma, mouse pre-osteoblast cells). The goal of this study was to investigate the cytotoxic properties of magnesium-titanium microparticles in application to treating bacterial infections (specifically for implant-related infections) and cancer. Galvanically coupled magnesium-titanium particles killed cancer cells very effectively at low particle concentrations (in ug/ml unit range), which is the dosage level that will not cause adverse effects. Particles also killed implant-based biofilms, which are hard to eradicate using conventional antibiotics, often causing implant removal after orthopedic infection.

Project Title: Studying the Factors that Affect the Corrosion and Failure of Hip Implants

• Assessed the effects of loading magnitude, loading frequency, hip design/geometrical factors, different material combinations, and electrochemical conditions on corrosion and micro-motion at the hip head/neck modular junction of hip implants.

Research Assistant, M.S. at Syracuse University (January 2010-December 2012) Syracuse NY

Capstone Project Title: The Effect of Pluronic F-127 on the Cell Viability of MC3T3 Cells

• Researched on retrieving stem cells from chicken embryos and analyzing the effect of pluronic F-127 gel on cell viability using MC3T3 mouse pre-osteoblast cells, in application to use pluronic F-127 as a matrix to culture the stem cells and differentiate them into chondrocytes by applying mechanical loading.

Project Title: Modes of Hip Implant Failure

• Analyzed retrieved hip implants from patients to determine the modes of failure.

Undergraduate Research Assistant, B.S. at Syracuse University (January 2009-December 2009) Syracuse NY

Senior Thesis Title: Potentiodynamic Polarization Testing of CoCrMo Alloy

• Performed potentiodynamic polarization testing on cobalt-chromium-molybdenum alloys that were held at different cathodic potentials for a certain period of time in order to determine how the history of cathodic potentials prior can affect the electrochemical behavior of the oxide layer. History of applying cathodic potential forms defective and weak oxide films, and therefore, more likely to cause corrosion of the metal.

Senior Capstone Project Title: Advanced Cardiovascular Life Support (ACLS)

• Designed an educational online flash game for Advanced Cardiovascular Life Support (ACLS) that will teach the players about the skills and knowledge regarding cardiovascular and respiratory emergencies.

Teaching Assistant for Biomaterials and Medical Devices at Syracuse University (Spring 2016 and Spring 2012) Syracuse NY

• This class involved teaching undergraduate and graduate students majoring in biomedical engineering and biotechnology (60-80 students per class).
• Teaching this course required a good understanding of biomaterials used in medical devices and implants, biological systems involved with medical devices, and the design and performance of biomaterials-based medical devices.

Lab Instructor for Quantitative Physiology at Syracuse University (Spring 2013) Syracuse NY

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required a good understanding of mammalian physiology from an engineering perspective, where each of the major systems of the body is addressed with an emphasis on electrical, mechanical, and thermodynamic principles.
• The lab portion required extensive use of data acquisition software LabVIEW and MATLAB. Also, experienced animal dissection and/or handling.
• Conducted a lab that involved dissecting a frog to retrieve a leg muscle and then stimulating the sciatic nerve to show that it controls the behavior of the gastrocnemius muscle and using MATLAB to assemble Windkessel model to study the fluid behavior in the cardiovascular system, especially in different cardiac conditions. This lab also involved handling a live rat to measure its frequency and tidal volume of respiration when delivering various mixtures of respiratory gases.

Lab Instructor for Bioengineering Laboratory at Syracuse University (Fall 2012) Syracuse NY

• This class involved teaching undergraduate (junior-senior level) students majoring in biomedical engineering (20-30 students per class).
• Teaching this course required good understanding of designing, executing, and analyzing experiments related to biomechanics and bioinstrumentation. This course required extensive use of AutoCAD and LabVIEW.
• Conducted a lab that involved designing, constructing, and/or improving the existing designs of a breathalyzer, a simple respiration monitor utilizing thermistor, photopleth heart rate monitor, and hemodialysis cartridge. The students used AutoCAD to design their products and acquired data using LabVIEW to test their products. Once the students designed their hemodialysis cartridge using AutoCAD, their designs were 3D printed.

Teaching Assistant for Engineering Materials, Properties, and Processing at Syracuse University (Fall 2011) Syracuse NY

• This class involved teaching undergraduate (junior level) students majoring in engineering (130-180 students per class).
• Teaching this course required good understanding of the relationships between processing, structure, properties, and performance of materials.

Summer Intern at LG Electronics (June-August 2006) Seoul South Korea

• Modified and improved an existing LG-brand motor for washing machines in performance without the increase of the cost and designed a new marketing strategy to sell the motor competitively in the motor market.

Marketing Agent/Salesperson at LG Telecom (June-August 2007) Seoul South Korea

• Collaborated with a marketing strategy team to sell the latest cellphones. Visited LG Telecom stores to determine which cellphones were sold the best to different customers, depending on their age, gender, and economy.

1. Kim J, Gilbert JL. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles, Acta Biomater. 2016; 30: 368-77. DOI: 10.1016/j.actbio.2015.11.030.
2. Kim J, Gilbert JL. The Effect of Cell Density, Proximity, and Time on the Cytotoxicity of Mg and Galvanically Coupled
Mg-Ti Particles In Vitro, J. Biomed. Mater. Res. A. 2018; 106(5): 1428-39. DOI: 10.1002/jbm.a.36334.
3. Kim J, Gilbert JL. In Vitro Cytotoxicity of Galvanically Coupled Magnesium‐Titanium Particles on Human Osteosarcoma SAOS2 Cells: A Potential Cancer Therapy, J. Biomed. Mater. Res. B. Appl. Biomater. 2018; 107(1): 178-89. DOI: https://doi.org/10.1002/jbm.b.34109.

4. Kim J, Gilbert JL. Cytotoxic Effect of Galvanically Coupled Magnesium-Titanium Particles on Escherichia Coli, J. Biomed. Mater. Res. B. Appl. Biomater. DOI: 10.1002/jbm.b.34864.

5. Ouellette ES, Mali S, Kim J, Grostefon J, Gilbert JL. Design, Material, and Seating Load Effects on In Vitro Corrosion Performance of Modular Head-Neck Tapers, J. Arthroplasty. 2019; 34(5): 991-1002. DOI: 10.1016/j.arth.2019.01.043.

6. Luechtefeld T, Lin N, Kim J, Paller CJ, Bressler J. TET1 Survival Model Molecular Mediation Experiments in Glioma, Cancer Res. 2019; 79(13): 4255. DOI: 10.1158.1538-7445.AM2019-4255.

7. Kim J, Bressler J, Paller CJ, Luechtefeld T, Begum A. Genes and Molecular Pathways in Glioblastoma: A Protocol of a “Living” Systematic Review, Prospero: International Prospective Register of Systematic Reviews. Registered with ID: CRD42018088817.

8. Deng K, Du P, Liu K, Tao X, Harati J, Jhang JW, Kim J, Wang PY. Programming Colloidal Self-Assembled Patterns (cSAPs) into Thermo-Responsible Hybrid Surfaces for Controlling Human Stem Cells and Macrophages, ACS Appl. Mater. Interfaces. 2021; 13(16): 18563-80. DOI: 10.1021/acsami.1c02969.

9. Enkhbat M, Liu YC, Kim J, Xu Y, Yin Z, Liu TM, Deng CX, Zou C, Xie X, Li X, Wang PY. Expansion of Rare Cancer Cells into Tumoroids for Therapeutic Regimen Cancer Therapy, Adv. Ther. 2021; 4(7): 2100017. DOI: 10.1002/adtp.202100017.

10. Kim J, Pan H. Understanding the Effect of Magnesium Corrosion: The Systematic Interaction Between Metal and Cells, Prog. Mater. Sci., In Progress.

1. Kim J and Gilbert JL. "Cytotoxicity of Galvanically Coupled Magnesium-Titanium Particles on Human Osteosarcoma." Stevenson Lecture, Syracuse University, Syracuse, New York; March 2016. Won Second Place in Stevenson Biomaterials Research Poster Session.
2. Kim J and Gilbert JL. “Proximity and Cell Density Effects on the Killing Ability of Mg and Mg-Ti Microparticles In-Vitro.” Annual Meeting of the Society for Biomaterials, Boston, Massachusetts; April 2013.
3. Kim J and Gilbert JL. "Cytotoxicity of Mg-Ti Particles for Targeted Therapeutic Effect." Stevenson Lecture, Syracuse University, Syracuse, New York; November 2012.

4. Kim J and Gilbert JL. “Cytotoxicity of Mg-Ti Particles for Targeted Therapeutic Effect.” 9th World Biomaterials Congress, Chengdu, China; June 2012.

• Surfaces of Biomaterials (able to teach this course material)*
• Engineering Materials, Properties, and Processing (able to teach this course material)*
• Biomaterials and Medical Devices (able to teach this course material)*
• Engineering Analysis of Living Systems (able to teach this course material)*
• Advanced Biomechanics/Advanced Biomechanics Lab
• Skeleto-Muscular Biomechanics
• Cardiovascular Engineering
• Electrical Engineering Fundamentals
• Electrical Engineering Laboratory
• Polymer Physics
• Analysis of Polymeric Literature
• Drug Delivery
• Cellular Physiology
• Metals in Medicine
• Introduction to Immunology
• Introduction to Virology
• Principles of Tissue Engineering
• Advanced Neuroscience
• Anatomy & Physiology
• Control of Robots
• System and Signal Analysis
• Anatomy and Physiology
• Mechanics of Solids

Wechat / Kakaotalk ID: talk2jua

Additional E-mail Addresses:

• jkim90@syr.edu (Syracuse University e-mail)
• jua@juakim.com (official e-mail)
• talk2jua@outlook.com (personal e-mail)
• lovtheqt@gmail.com (personal e-mail)

Additional Phone Numbers:

• +1-240-545-5444 (USA)
• +82-10-8744-5444 (South Korea)

Linked-In Profile:

• https://www.linkedin.com/in/juakim87/

Website:

• https://www.juakim.com