Justine Curley, Ph.D.

• Develop and maintain relationships with key opinion leaders in epilepsy throughout my territory bringing them the latest research and clinical data on VNS Therapy.
• Bring insights from discussions in the field to internal R&D and clinical strategy teams.
• Arrange and facilitate meetings between KOLs in academic centers in Boston and New York and the executive leadership team.
• Coordinated development and application of two funded IIRs, one with potential to add an indication to the FDA label and one with potential to add features to the next generation of the device.
• Mentor junior team members in their first MSL roles.
• Train epilepsy fellows at level 4 epilepsy centers on VNS Therapy and started the first cadaver lab training program for neurosurgery residents for VNS implants.
• Attend national and regional conferences in epilepsy and neurology and bring insights back to internal stakeholders.
• Collaborate on analyses and publications from a 3-year clinical study of more than 800 patients with VNS.

• Project manager on two studies investigating the role of the prenatal immune environment on aging of stress response circuitry and vulnerability to Major Depressive Disorder in midlife.
• Responsible for collection and analysis of structural and functional MRI, serological, physiological, and neuropsychological data, and synthesis of data from multiple modalities into models of sex differences in neuropsychiatric disorders.
• Primary writer on five manuscripts and two funded grants.
• Mentor to junior scientists in the lab.

• Postdoctoral researcher on two longitudinal studies examining the effects of sex and aging on stress response neural circuitry in adults with a history of major depression.

Other research projects included:

• Functional connectivity in the default mode network at different stages of reproductive aging, in healthy and depressed men and women in early midlife.
• Effects of increased levels of pro-inflammatory cytokines in utero on stress circuitry activity and connectivity in early midlife subjects with neuropsychiatric disorders.
• Analysis of sex differences in the neural response to varying levels of stress in young adults using fMRI activation and connectivity and adrenal hormone levels.

• Investigated the importance of prediction in neural activity and cortical rhythms underlying context-dependent memory and disambiguation of overlapping sequences using fMRI and EEG in human subjects.
• Development of novel episodic memory tasks using virtual reality (POV-Ray) and E-Prime software.
• Teaching fellow for physiological psychology course and mentor to undergraduate researchers.

• Researched, wrote, edited, and coordinated the production of documents for submission to FDA and non-US regulatory bodies for several clinical research trials across a range of therapeutic areas including neurology, oncology, and musculoskeletal and cardiovascular indications.
• Performed quality control review of written materials for the Medical Imaging group.
• Participated in industry-wide harmonization committees.
• Provided guidance to junior staff members.

• Performed immunostaining and imaging of tissue and live cells for a histology and microscopy core facility.
• Trained all users on advanced imaging equipment and created training materials.

• Histological and confocal data collection for research using a transgenic mouse model study the role of sex hormones and apolipoprotein E in susceptibility to Alzheimer's disease.
• Assisted in coordinating a clinical study in which studies with mice were extrapolated to elderly subjects using virtual reality paradigms mimicking the Morris water maze and novel object recognition tests.

• Assisted in design and implementation of a multiple user imaging and histology core facility servicing several laboratories studying the effects of alcohol on the brain.
• Performed sectioning, immunostaining, in situ hybridization, and confocal and light microscopy of brain tissue.
• Consulted on neuroanatomical findings.