Kartik Ramasubramanian
Blue Bell,PA
Summary
Chemical engineer with nine and half years of industrial experience in R&D and manufacturing, and passion for difficult problem solving using data analysis, continuous improvement, and cross-functional collaboration.
Overview
16
16
years of professional experience
Work History
Senior Process Engineer, Upstream
Merck
Elkton, USA
09.2022 - 09.2023
- Manage and mentor new process engineers to ensure timely and sound on-the-floor technical support to operations
- Led development of batch sheets and SOPs for engineering and PPQ batches, and Manufacturing Execution System (MES) implementation
- Led deviation investigations and implemented effective corrective and preventive actions
- Conceptualized, plan, and implement changes to critical sugar flow meter installation and calibration control to resolve chronic under-performance
Senior Chemical Engineer, Downstream
Merck
Elkton, USA
03.2020 - 08.2022
- Provided rigorous technical support for downstream processing of fermentation broth to Caspofungin API (small molecule lipopeptide antifungal)
- Investigated and resolved obstruction in critical process transfer pump by analyzing large datasets of outlet pressure for different flow paths across multiple years
- Resolved chronic treated water conductivity problem using trend analysis and hypothesis testing and implemented restorative maintenance of oxygen generator as an effective solution
- Led installation and qualification of new ozone generator to supply water for GMP manufacturing
- Brought about step-improvement in safety performance by ensuring no spills and injuries
Site in Technical Manager
The Lycra Company
Waynesboro, USA
03.2019 - 02.2020
- Supervised process engineers and provided 360-degree feedback
- Oversaw commercial scale-up of processes in alignment with technical transfer documents
- Worked with Quality, R&D, Tech marketing, and Sales functions to achieve site and regional goals
Lead Process Engineer
The Lycra Company
Waynesboro, USA
11.2015 - 03.2019
- Led tech transfer of a new product family of black Lycra fiber
- Managed a cross-functional project using Six Sigma principles to restore a twenty five-year old asset to design standards, validated changes through fabric manufacturing experiments at international customers, and ensured optimal asset utilization to produce > $10MM Lycra fiber annually
- Implemented equipment upgrades to resolve chronic quality issues through cause mapping and in-depth product testing
- Visited international customers to build relationships and conduct trials for new product commercialization
R&D Chemical Engineer
The Lycra Company
Waynesboro, USA
01.2014 - 11.2015
- Led pilot-scale experiments to evaluate impact of process and equipment attributes on fiber and fabric uniformity
- Designed experiments to quantify effects of additives on fluid rheology and product properties
- Developed a new fiber along-length variability parameter to explain trends in data gathered via competitive benchmarking and used it as a product quality attribute for process development
Chemical Engineering PhD Candidate
Ohio State University
Columbus, USA
09.2007 - 08.2013
- Developed a novel technique for coating inorganic colloidal dispersions on polymer supports and fabricating inorganic-polymer thin film composite (TFC) membranes - U. S. Patent No. 9216390 (2015), U. S. Patent No. 10322379 (2019), and publication in Journal of Colloid and Interface Science (2015)
- Developed process and cost models of CO2 capture membranes - Journal of Membrane Science (2012)
- Developed and validated model of membrane reactor in spiral-wound geometry by solving a system of simultaneous non-linear partial differential equations describing mass, energy, and momentum balances - Industrial & Engineering Chemistry Research (2013)
- Laid the foundation for a critical research trajectory in the lab by installing, troubleshooting, and operating a pilot-scale continuous TFC membrane fabrication machine for fuel cell H2 purification
Education
Ph.D. - Chemical Engineering
The Ohio State University
Columbus, OhioChemical Engineering PhD Candidate -
Ohio State University
Columbus, OHBachelor of Chemical Engineering -
Institute of Chemical Technology
Mumbai, IndiaSkills
- People management
- Technical and scientific writing
- Project management
- Statistical process and quality control and Six sigma principles
- Scale-up and Tech transfer
- Process validation and Continued process verification
- Root cause analysis and Deviation investigations
- GMP documentation
- Change controls
- MES implementation
- Quality systems and Data integrity
- Clean room best practices
- Design of experiments, Multi-variate regression and Quality by Design
- Downstream and upstream pharmaceutical unit operations
- Chromatography, crystallization and filter drying
- Tangential and normal flow filtrations
- Fermentation and Harvest unit operations
- HPLC column packing and testing
- PLCs and Distributed control systems such as DeltaV
- Clean-in-place and Sterilize-in-place
- Rheology of non-Newtonian fluids
- Mixing
- Organic reactions
- Gas separations
- Continuous polymerization
- Polymer processing
- Drying and spinning of polymeric fibers
- Fabrication of polymer and polymer-inorganic membranes
- Gas permeation units
- Membrane transport characterization
- Viscometry
- Gas chromatography
- Spectroscopy
- Scanning electron microscopy
- Aspen process explorer and PI system
- Data analysis and visualization, Minitab, JMP
- Process modeling
- COMSOL Multiphysics
- Numerical solving techniques
- MATLAB
Google Scholar Profile
https://scholar.google.com/citations?user=lTl_VWwAAAAJ&hl=en&oi=ao
Recognitions
- American Institute of Chemists Foundation Award, 2013
- Outstanding Graduate Research Award, Chemical and Biomolecular Engineering Department, 2011
- Outstanding Graduate Research Award, Chemical and Biomolecular Engineering Department, 2012
- American Institute of Chemical Engineers Separations Division Graduate Student Research Award, 2011
- Best Teaching Associate Award, The Ohio State University, 2009
Timeline
Senior Process Engineer, Upstream
Merck
09.2022 - 09.2023
Senior Chemical Engineer, Downstream
Merck
03.2020 - 08.2022
Site in Technical Manager
The Lycra Company
03.2019 - 02.2020
Lead Process Engineer
The Lycra Company
11.2015 - 03.2019
R&D Chemical Engineer
The Lycra Company
01.2014 - 11.2015
Chemical Engineering PhD Candidate
Ohio State University
09.2007 - 08.2013
Ph.D. - Chemical Engineering
The Ohio State University
Chemical Engineering PhD Candidate -
Ohio State University
Bachelor of Chemical Engineering -
Institute of Chemical Technology