Lana Pierotich (ex Vasung)

• Reporting directly to the CMO
• Led the development and preparation for execution of clinical trial strategies for gene editing, successfully guiding programs from pre-clinical stages towards the human proof-of-concept trials.
• Collaborated cross-functionally with research, clinical sciences, regulatory affairs, and clinical operations teams to design and implement efficient and safe clinical trials across multiple therapeutic areas.
• Authored and conceptualized clinical trial protocols across early phases (I-II), ensuring alignment with scientific and regulatory standards.
• Represented clinical development in cross-functional program teams, contributing strategic insights and ensuring seamless integration of clinical development with broader organizational objectives.
• Organized and led Scientific Advisory Boards, facilitating feedback from Key Opinion Leaders (KOLs) to inform clinical trial design and therapeutic strategy.
• Supported regulatory interactions, including the preparation and submission of regulatory documents, and participated in discussions with regulatory agencies to drive clinical development forward.
• Collaborated with pre-clinical research teams to develop and implement translational biomarker programs, analyzing data to optimize clinical trial outcomes.
• Actively participated in scientific and medical conferences, presenting Prime Medicine’s data and staying informed on emerging trends and advancements in gene therapy and related therapeutic fields.
• Participated at regulatory meetings, and conferences, fostering relationships with key stakeholders and ensuring smooth trial strategy development.

Leveraged an existing fetal MRI cohort from the Advanced Maternal-Fetal Care Center at Boston Children’s Hospital with the aim to analyze MRI using state-of-the-art MRI tools and characterize the fetal brain structure. Identifying regions that are

altered during development in different disorders of the brain and/or body (e.g., congenital heart disease, ventriculomegaly, hydrocephalus, Chiari II malformation) helped in characterizing the neural substrate of the impaired neurodevelopmental outcome seen in these children after birth.

In the future, these biomarkers will be used to develop clinical risk stratification

tools and to guide preventive and therapeutic interventions in this vulnerable clinical population. I directly contributed to planning and selecting the best animal model for fetal in-utero neurosurgical interventions, with an emphasis on detailing approaches for pre-surgical planning and developing strategies for in-vivo fetal CNS tissue collection or agent delivery.

Selected Achievements:

● Completed a research project as a PI funded by the Harvard Catalyst (Clinical and Translational).

● Published several peer-reviewed articles in high-impact journals such as Nature and Cerebral Cortex.

● Mentored four undergraduate students in various research activities.

● Built and maintained professional relations with competitors which led to joint publications.

● Submitted several NIH R21 and R01 grants including Innovator NIH grant.

As an instructor, my goals were to characterize normal brain development both in-utero and postnatally (during neonatal, infant, and childhood periods) using high-resolution MRI. Additionally, I aimed to characterize structural brain abnormalities

and identify imaging biomarkers of neurodevelopment outcomes (Bailey Scales of Infant and Toddler Development, neurological signs and symptoms) in children with neurological and brain disorders, such as agenesis of the corpus callosum. Leveraging my expertise in developmental neuroscience, I was able to contribute to technology development.

I reported directly to the Founding Director of the Fetal-Neonatal Neuroimaging and Developmental Science Center. My responsibilities included compiling and maintaining a neuroimaging and clinical outcome database in fetuses and children with rare genetic disorders, which was used to evaluate and interpret research results. Additionally, I led and coordinated multidisciplinary collaborations between clinicians, basic science researchers, and engineers at Boston Children’s Hospital. I

ensured seamless coordination of a multinational collaboration involving McGill in Canada, UNIGE and UNIL in Switzerland, Europe, FNNDSC in Boston, CHOP and UPenn in Philadelphia. I also contributed to NIH grant writing and designed research.

strategies in collaboration with partners at the Computational Radiology Laboratory, Newborn Medicine, and Department of Neurology.

Furthermore, I analyzed clinical data using NLME.

Selected achievements:

● Completed a research project as a Principal Investigator funded by the Swiss National Science Foundation (Title: Investigating the role of transient fetal zones and axonal fiber growth in relation to gyral formation in humans; https://

data.snf.ch/grants/person/601887).

● Published 17 peer-reviewed articles in high-impact journals such as PNAS, Neuroimage, and Cerebral Cortex.

● Mentored four undergraduate students in various research activities.

● Built and maintained professional relationships with competitors, resulting in joint publications

Reported directly to the Founding Director of the Child Development Center, University Hospitals Geneva, Geneva, Switzerland. Mentored and guided MD and PhD students through neuroscience research projects. Wrote three national

research grant proposals as a Principal Investigator and postdoctoral fellow. Led the planning and implementation of several international collaborations for research. Developed and executed clinical research strategies.

Selected Achievements:

● Published 17 scientific articles in leading journals such as Cell, Cerebral Cortex, Clinics in Perinatology, and contributed to

several book chapters (e.g., Toga et al., Brain Mapping: An Encyclopedic Reference).

● Completed two years of profound clinical training in neuroradiology.

● Led and concluded a nationally funded project with the University of Geneva titled 'From Cortex to Classroom: Enhancing

Brain Development for Premature Infants’.

Reported directly to the Founding Director of the Croatian Institute for Brain Research. Founded and guided the Student’s Section for Neuroscience and Croatian Student Summits, taking on a leadership role. Interpreted and analyzed the results of

diagnostic tests and communicated with patients to evaluate progress. Initiated several international collaborations.

Selected Achievements:

● Published four scientific articles in leading journals such as Annals of New York Academy of Sciences, Seminars in Perinatology, and Brain Structure and Function.