Leela Sai Lokesh Janardhanam
Iowa City,IA
Summary
Knowledgeable researcher with a robust background in scientific research and advanced analytical techniques. Notable for contributing to groundbreaking studies and publishing in peer-reviewed journals. Demonstrated expertise in data analysis and experimental design, showcasing strong problem-solving and critical thinking skills.
Overview
11
11
years of professional experience
Work History
Postdoctoral researcher
The University of Iowa
06.2023 - Current
- Formulated PLGA nanoparticles co-loaded with encorafenib and trametinib at a fixed dose ratio
- Nanoparticles were surface conjugated with cRGD to target colon cancer
- Conducted drug screening studies using cell viability assay and xenograft cancer model in nude mice to identify novel synergistic drug combinations against BRAF and KRAS mutated colon cancer model
- Optimized exosomes isolation techniques and high drug loading in exosomes for the application of drug delivery
Formulation Scientist
Dr. Reddy's Laboratories
02.2022 - 05.2023
- Ideation and development of differentiated drug products with better therapeutic efficacy for emerging markets
- Troubleshooted the stability of a proton pump inhibitor molecule and redesigned the pellet coatings using Wurster coating techniques
- Conducted the drug-excipient compatibility studies to identify the source of impurity generation
- Responsible for preparing the product specifications and manufacturing records to execute scale-up batches
Project Assistant - Department of Science and Technology (DST, Govt. of India)
BITS Pilani - Hyderabad campus
10.2017 - 02.2022
- Worked on developing Layer-by-Layer self-assembled polymeric patches for the oral delivery of oxaliplatin and STAT3 siRNA
- Optimized polymer coating on hard gelatin capsule for the pH dependent delivery in colon region
- Obtained hands on experience with FTIR, DSC, TGA and pXRD techniques by analyzing the drug properties loaded in polymeric patch
- Development of dissolvable microneedles for the localized delivery of chemotherapeutics for treating oral cancer
- Analyzing the stability of patches and nanoparticles following ICH guidelines
Research Associate -III
Aurobindo Pharma Ltd.
06.2017 - 10.2017
- Generic formulation development of tablets for vaginal drug delivery
- Provided technical inputs in designing and developing the potent handling laboratory
Executive
Aizant Drug Research Solutions Pvt. Ltd.
04.2015 - 06.2017
- Development of a bilayer anti-diabetic tablet with a dual drug release profile
- Developed the generic formulation of anti-breast cancer molecules and supported for its 505b filing to the US Market
- Actively involved in preparing standard operating procedures (SOP's) for the lab scale instruments
- Designing and execution of formulation-related experimental trials, excipient compatibility and stability studies of solid oral dosage forms like tablets, capsules, pills with delayed and modified release behavior
- Evaluating & reasoning of in-process changes and results and taking necessary actions from time to time to improve the quality of the product and giving inputs for compilation reports
Executive trainee
Aizant Drug Research Solutions Pvt. Ltd.
04.2014 - 03.2015
Education
Postdoctoral Fellowship - Nano Formulations
University of Iowa
Iowa City, IA12.2025
Ph.D. - Drug and Gene Delivery
BITS Pilani
Hyderabad01.2022
Pharmaceutics
Jawaharlal Nehru Technological University Kakinada (JNTUK)
01.2015
Bachelors - Pharmacy
NRI College of Pharmacy
01.2012
Skills
- Zeta Sizer (NanoZS, Malvern instruments)
- Nanoparticle tracking analysis (NTA)
- Microfluidics (PreciGenome)
- HPLC (Shimadzu and Waters)
- DSC (Shimadzu)
- In vitro imaging system (IVIS, Lumina III, PerkinElmer)
- Pharmacokinetic and bio-distribution analysis
- Cell culture - in vitro assays
- Animal handling and dosing
- Orthotopic, syngeneic and orthotopic tumor model development in mice
- GraphPad Prism
- BioRender
- Winnonlin
Publications And Patents
- No. of patents filed: 01
- No. of papers published (last 5 years): 07
- Books or book chapters published: 01
- National and international conferences attended: 07
Education And Fellowship
- Postdoctoral Fellowship, The University of Iowa, 06/01/23, Present
- Ph.D. in Drug and Gene Delivery, BITS Pilani - Hyderabad campus, 01/01/17, 12/31/22
- Masters in Pharmaceutics, Jawaharlal Nehru Technological University Kakinada (JNTUK), Andhra Pradesh, 01/01/12, 12/31/15
- Bachelors in Pharmacy, NRI College of Pharmacy, Affiliated to Acharya Nagarjuna University, 01/01/08, 12/31/12
Awards
- Best poster award at ATMOS-Current Trends in Pharmaceuticals, BITS Pilani- Hyderabad Campus, 11/01/19, For the topic titled 'Proof of concept: Efficacy of smart capsule containing 5-fluorouracil loaded Janus membrane using Caco-2 spheroid model mimicking colon cancer'.
- Research fellow grant, Department of Science and Technology - Science and Engineering Research Board (DST-SERB), Gov of India, 01/01/17 to 12/31/20
- Qualified in the Graduate Pharmacy Aptitude Test (GPAT-2012), All India Council for Technical Education (AICTE), 01/01/12, Received a scholarship from 2012 to 2014.
Timeline
Postdoctoral researcher
The University of Iowa
06.2023 - Current
Formulation Scientist
Dr. Reddy's Laboratories
02.2022 - 05.2023
Project Assistant - Department of Science and Technology (DST, Govt. of India)
BITS Pilani - Hyderabad campus
10.2017 - 02.2022
Research Associate -III
Aurobindo Pharma Ltd.
06.2017 - 10.2017
Executive
Aizant Drug Research Solutions Pvt. Ltd.
04.2015 - 06.2017
Executive trainee
Aizant Drug Research Solutions Pvt. Ltd.
04.2014 - 03.2015
Postdoctoral Fellowship - Nano Formulations
University of Iowa
Ph.D. - Drug and Gene Delivery
BITS Pilani
Pharmaceutics
Jawaharlal Nehru Technological University Kakinada (JNTUK)
Bachelors - Pharmacy
NRI College of Pharmacy
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