Madelyn Pickett

Highly-motivated graduate student with desire to take on new challenges. Successful collaborator on both biomedical research and project management teams. Strong work ethic, adaptability, and interpersonal skills and a quick ability to master new skills.

In-Space Production of Janus Base Nanomaterials for Drug Delivery and Tissue Regeneration (Master's Thesis) - 06/2023-05/2025

• Developing novel DNA-inspired Janus-base nanomaterial technology (JBNs) to carry drug cargos as a therapeutic delivery vehicle in the form of Janus Base Nanopieces (JBNps) and combined with protein as a matrix to form Janus Base Nanomatrix (JBNm) for supporting tissue regeneration
• Working in collaboration with NASA/ISS and Axiom Space to study the effects of microgravity on the fabrication of JBNs

Neuronal Cell Viability in Soft Hydrogels for modeling Traumatic Brain Injury - 08/2022-05/2023

• Fabricated gelatin-alginate based hydrogels of various concentrations through cross-linking to accurately mimic brain matter for studying Traumatic Brain Injury
• Encapsulated neuronal cells within hydrogels to design a viable 3D scaffold
• Performed an MTS (Cell Proliferation) Assay to study the biocompatibility of the hydrogel scaffold

Characterization of Breast Cancer Cell Subtypes through Mechanical Stiffness - 11/2022-05/2023

• Cultured multiple cell lines simultaneously (obtained from Cornell Medicine) of varying breast cancer cell subtypes which were formed into cell spheroids for later experimentation
• Tested the mechanical stiffness of breast cancer cell spheroids using unique micro-tweezer technology developed in the Hoshino Lab and analyzed the differences in stiffness

Design of a Microphysiological Tissue Chip to mimic cartilage for in vitro studies of Arthritis- 01/2022-05/2022

• Collaborated with group members to successfully design the product and its features& utilized CAD software to model the design
• Completed six project reports outlining the functionality and components of the device