Overview
Work History
Education
Skills
Awards
Academic Contribution
Other
Conferences
Publications
Timeline
Generic

Mariarosaria Cuozzo

Overview

7
7
years of professional experience

Work History

PhD visiting student

APC Microbiome Ireland
Cork, Ireland
01.2023 - 12.2023
  • Worked on projects centered around the microbiome-gut-brain axis in Women’s Health
  • Specifically assessed the role of the microbiome and inflammation in Endometriosis.

PhD in Pharmaceutical Sciences

University of Naples Federico II
Naples, Italy
01.2020 - 01.2024
  • Focused on microbiota-gut-brain axis in pain processing and associated mood disorders
  • Explored chemotherapy-induced intestinal microbiota alteration and its correlation with peripheral manifestations such as neuropathic pain and central repercussions like anxiety and depression
  • Targeted microbiota with psychobiotic compounds or their metabolites as therapeutic tools.

Training Period in Pharmacology

University of Naples Federico II
Naples, Italy
01.2017 - 01.2019
  • Worked on the project entitled “Characterization of new TRPM8 modulators in pain perception”
  • To better understand the role of this channel in pain, in this study, we tested two compounds, an agonist and an antagonist of TRPM8 receptor, previously evaluated in vitro, in either acute or chronic pain models using both systemic and local routes of administration.

Education

Ph.D. in Pharmacology, Pharmaceutical Sciences, XXXVI Cycle -

University of Naples Federico II
01.2024

II Level Masters - Preclinical and clinical drug development and post-marketing monitoring

University of Naples Federico II
01.2020

Master degree in Pharmacy -

University of Naples Federico II
01.2019

Skills

  • IN VIVO techniques: Behavioral tests in both mice and rats - To assess pain perception (Von Frey, Randall-Sellitto, Hot plate, Acetone evaporation test, Acetic-acid writhing test, Formalin-induced paw pain) To assess mood disorders like anxiety and depression (Tail suspension test, forced swimming test, light/dark box and elevated plus maze tests)
  • IN VITRO techniques: Cell culture (Neuro-2a mouse neuroblasts, HaCaT cells, VK2/E6E7 epithelial cell line): cellular assay development, cell stimulation, cell viability assay (MTT assay), Mycoplasma contamination analysis Bacteria culture (Lactobacillus rhamnosus and Roseburia intestinalis): growth in different growth medium (GOS addition), preparation of bacterial supernatants, cells treatment with bacterial supernatants
  • EX VIVO analysis: Western blotting, ELISA, RNA extraction, gene expression through RT-PCR and GC/MS analysis
  • Statistical analysis and graph design
  • Excellent written skills and good oral communication and active listening skills, thanks to several publications and attending conferences
  • Eager to learn, efficient, dynamic and organized in a laboratory, punctual, with adaptability, able to work in a team, easy to work with and always striving for excellence

Awards

2019: "Paola Persico Association” award for best experimental graduation thesis recognized the hard work, innovation, and impact of my team researcher's work.

2023: "SIF research fellow for short periods abroad” for visiting training period

Academic Contribution

  • 2020-present, Italian Society of Pharmacology, Member
  • From 2022, Department of Pharmacy, University of Naples Federico II, PhD Mentor for international Erasmus and/or PhD Students
  • October 2023, Irish Pain Society Annual Meeting, Cork, Ireland, Worked in the organization and successful running of the event

Other

XXV Conference of Young SIF Pharmacologists, September 5-8, 2023, Urbino, PU, Chairperson during the oral communications Session “Miscellaneous I”

Conferences

  • 44 National Congress of the Italian Association for the Study of Pain (AISD), September 23-25, 2021, Rome, Italy, Oral Communication, Microbiota-gut-brain axis involvement in pain syndrome: biomolecular pathway and potential therapeutic strategies
  • 1st Joint meeting on Natural Products Pharmacology SIF - SIPHAR – IMGNPP, February 24-26, 2022, Naples, Italy, Poster presentation, Effects of chronic oral post-biotic treatment in neuropathic pain
  • 41 National Congress Of The Italian Society Of Pharmacology - The scientific value and appropriate use of the drug, November 16-19, 2022, Rome, Italy, Poster presentation, Effect of Sodium Butyrate on peripheral and central alterations induced by paclitaxel-based chemotherapy
  • XXV Conference of Young SIF Pharmacologists, September 5-8, 2023, Urbino, PU, Oral Communication, Role of bioactive endogenous fatty acids in the regulation of Paclitaxel-induced toxicity
  • XXV Conference of Young SIF Pharmacologists, September 5-8, 2023, Urbino, PU, Poster presentation, Role of bioactive endogenous fatty acids in the regulation of Paclitaxel-induced toxicity
  • The 3rd International Conference on Controversies in Neuropathic Pain, November 20-21, 2023, Brussels, Belgium, Oral Communication, The Beneficial Effects of Sodium Butyrate in the Management of Neuropathic Pain Induced by Paclitaxel in Mice
  • The 3rd International Conference on Controversies in Neuropathic Pain, November 20-21, 2023, Brussels, Belgium, Poster presentation, The Beneficial Effects of Sodium Butyrate in the Management of Neuropathic Pain Induced by Paclitaxel in Mice

Publications

  • Cacciola NA, Venneri T, Salzano A, D'Onofrio N, Martano M, Saggese A, Vinale F, Neglia G, Campanile C, Baccigalupi L, Maiolino P, Cuozzo M, Russo R, Balestrieri ML, D'Occhio MJ, Ricca E, Borrelli F, Campanile G., Chemopreventive effect of a milk whey by-product derived from Buffalo (Bubalus bubalis) in protecting from colorectal carcinogenesis., Cell Commun Signal, 2023 Sep 20, 21(1), 245, 10.1186/s12964-023-01271-5, 37730576, PMC10510155
  • Cristiano C, Giorgio C, Cocchiaro P, Boccella S, Cesta MC, Castelli V, Liguori FM, Cuozzo MR, Brandolini L, Russo R, Allegretti M., Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy., Cytokine, 2023 Nov, 171, 156370, 10.1016/j.cyto.2023.156370, 37722320
  • Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, Piscitelli F, Abolghasemi A, Gazzerro E, Silvestri C, Capasso R, Motta A, Russo R, Di Marzo V, Iannotti FA., Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy., EMBO Mol Med, 2023 Mar 8, 15(3), e16225, 10.15252/emmm.202216225, 36594243, PMC9994484
  • Cuozzo M, Cristiano C, Coretti L, Liguori FM, Cimmino F, Turco L, Avagliano C, Aviello G, Mollica MP, Lembo F, Russo R., Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction., Biomed Pharmacother, 2022 Sep, 153, 113528, 10.1016/j.biopha.2022.113528
  • Avagliano C, De Caro C, Cuozzo M, Liguori FM, La Rana G, Micheli L, Di Cesare Mannelli L, Ghelardini C, Paciello O, Russo R., Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels., Front Pharmacol, 2022 Aug 11, 13, 930832, 10.3389/fphar.2022.930832
  • Cristiano C, Avagliano C, Cuozzo M, Liguori FM, Calignano A, Russo R., The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice., Biomolecules, 2022 Aug 20, 12(8), 1155, 10.3390/biom12081155
  • Sodano F, Cristiano C, Rolando B, Marini E, Lazzarato L, Cuozzo M, Albrizio S, Russo R, Rimoli MG., Galactosylated Prodrugs: A Strategy to Improve the Profile of Nonsteroidal Anti-Inflammatory Drugs., Pharmaceuticals (Basel), 2022 Apr 29, 15(5), 552, 10.3390/ph15050552
  • Sodano F, Avallone B, Tizzano M, Fogliano C, Rolando B, Gazzano E, Riganti C, Magliocca S, Cuozzo M, Albrizio S, Calignano A, Cristiano C, Russo R, Rimoli MG., Ketogal Safety Profile in Human Primary Colonic Epithelial Cells and in Mice., Pharmaceuticals (Basel), 2021 Nov 11, 14(11), 1149, 10.3390/ph14111149
  • Cuozzo M, Castelli V, Avagliano C, Cimini A, d'Angelo M, Cristiano C, Russo R., Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain., Biomedicines, 2021 Mar 30, 9(4), 346, 10.3390/biomedicines9040346
  • De Caro C, Cristiano C, Avagliano C, Cuozzo M, La Rana G, Aviello G, De Sarro G, Calignano A, Russo E, Russo R., Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System., Front Pharmacol, 2021 Feb 1, 11, 620221, 10.3389/fphar.2020.620221

Timeline

PhD visiting student

APC Microbiome Ireland
01.2023 - 12.2023

PhD in Pharmaceutical Sciences

University of Naples Federico II
01.2020 - 01.2024

Training Period in Pharmacology

University of Naples Federico II
01.2017 - 01.2019

Ph.D. in Pharmacology, Pharmaceutical Sciences, XXXVI Cycle -

University of Naples Federico II

II Level Masters - Preclinical and clinical drug development and post-marketing monitoring

University of Naples Federico II

Master degree in Pharmacy -

University of Naples Federico II
Mariarosaria Cuozzo