Summary
Overview
Work History
Education
Skills
Timeline
Generic

MARK D. BREZZELL

Summary

Executive Strategic Development, Two Indications. Cardiac and NeuroIntervention Strategic partnerships development and management and funding opportunities through extensive research and profiling. Cardiovascular Perfusionist Masters (Terminal) level with 10 years of clinical and 13 years Industry Medical Affairs experience. Strong Hematology/Oncology KOL network per Sickle Cell, Hemophilia and other benign hematology conditions. Clinical experience included working in OR, Cath lab, ED, and overseeing Institutional Blood Conservation program. Extensive expertise in blood and fluid management including albumin, synthetic colloid and plasma utilization. KOL development/Medical Affairs Associate Director level Research experience. Clinical Research experience Frequent presenter and speaker at industry conferences and clinical sites.

Results-oriented professional with extensive leadership experience in high-stakes environments. Skilled in strategic planning, operational optimization, and organizational growth. Known for fostering team collaboration and delivering results under changing conditions. Key strengths include strategic vision and stakeholder management.

Experienced with strategic planning and execution, ensuring alignment with organizational goals. Uses strong leadership capabilities to inspire and motivate teams toward success. Track record of leveraging financial acumen and stakeholder relationships to drive business growth.

Overview

30
30
years of professional experience

Work History

Executive/Sr Medical Science Liaison

Terumo Medical
05.2022 - 09.2025
  • Drive the development and implementation of the appropriate medical affairs strategy by providing medical scientific expertise
  • Lead and Organize advisory boards/expert panels to improve scientific knowledge, identify unmet needs and cover potential scientific gaps.
  • Medical affairs & scientific expertise: Cardiovascular Medicine.
  • Drive Scientific communication:
  • Strategic Marketing department collaboration:
  • Drive Clinical development planning:
  • Drive Clinical operational activities:
  • Cardiology Cardiovascular Medicine
  • Directed cross-functional teams to enhance operational efficiency and streamline processes.
  • Implemented strategic initiatives to optimize product development cycles and reduce time-to-market.

Oncology Executive Medical Science Liaison

Coherus Biosciences
02.2019 - 07.2020
  • Establish Coherus Biosciences as a leading company committed to oncology (and other therapeutic areas) and the advancement of biosimilars as a new treatment option.
  • Maintain clinical, scientific and technical expertise in relevant Oncology (and other disease state areas).
  • Have a thorough understanding of the biosimilar development process, biosimilar products, clinical protocols and related procedures.
  • Collaborate with medical affairs, clinical development, commercial and serve as a Coherus resource to HCPs, large group medical practices, payers and formulary decision makers.
  • Develop and track key opinion leader (KOL) engagement plans - identify, develop and maintain long-term collaborative relationships with KOLs within assigned region.
  • Participate in medical and scientific exchanges with the medical/ scientific community including advisory boards.
  • Provide medical/ clinical teams with feedback and insights from interactions with KOLs and investigators.
  • Respond to and document unsolicited requests for information on Coherus BioSciences' products and clinical programs.
  • Support internal requests for dossier review and comment, medical review/consideration of potential business development opportunities and other unique projects as requested.
  • Participate in/support the training of Coherus field and home office employees.
  • Facilitate research collaborations (including Real World Data [RWD] generation and investigator sponsored trials [IIS]) with key investigators including helping identify, establish and maintain such collaborations.
  • Represent the company at medical meetings through Medical Affairs' Scientific Booth coverage and other related activities.
  • Engage in speaker identification, training and evaluation and provide support for advisory board meetings as requested.
  • Collaborate with Market Access and Commercial colleagues for thought leader and institutional engagement where appropriate.
  • Adhere to corporate SOPs and ensure vigilant compliance with relevant legal and regulatory guidelines governing scientific interactions with physicians and healthcare professionals across all activities, including those related to clinical trials, scientific interactions with internal and external group.

Executive Consultant

BusStim LLC
05.2019 - 2020
  • Serve as the Executive in Residence (EIR) for BusStim LLC handling Business Development activities for Portfolio companies.
  • Assist with Fundraising for Spinal Resources Inc (Spinal Medical device Startup)
  • Medical Affairs Consultant for CytoSorbents Medical Device Company developing the CytoSorb for critical care immunotherapy, specializing in blood purification.
  • Led strategic initiatives to enhance operational efficiency within client organizations.
  • Developed comprehensive business analysis frameworks to drive data-informed decision-making processes.

Senior/Executive Medical Science Liaison

Prolong Pharmaceuticals
09.2014 - 05.2018
  • Drive drug development strategy for the utilization of SANGUINATE (Oxygen transfer agent) for Cardiovascular Intervention and Neuro Throbectomy space.
  • Direct the Identification of a Cardiac Indication in the Cardiac Space.
  • Direct the Indication of a Throbectomy Indication.
  • Tasked with the exploration and development of the Phase 2 Cardiovascular Surgery protocol.
  • Developed detailed Cardiovascular KOL list of potential investigators.
  • Direct and organize Cardiovascular Intervention and Neuro Intervention Scientific Advisory board.
  • Leverages in-depth medical-scientific knowledge, clinical expertise, and professional position from within the medical community as a credible peer to cultivate and integrate substantive relationships with key opinion leaders (KOLs), clinicians, academic institutions, professional organizations, and patient advocacy groups, rendering strong advocacy by these external customers for Prolong products, (ie SANGUINATE, ANF-Rho) Calling on Hematology/Oncology Clinicians in Sickle Cell.
  • Participation and execution of Clinical Operations duties assisting with Site Identification and Evaluation in prep for Phase 2 Sickle Cell Study.
  • Advisory for, and involvement, with product life-cycle management initiatives.
  • Outstanding company awareness and the establishment of a reputation as a collaborative scientific partner.
  • Directs the management of critical relationships with KOLs and external customers through the compliant exchange of complex scientific information related to Prolong Pharma areas of research, product development, and commercialization.
  • Directs the pairing of research and educational needs of external customers with available Prolong Pharma resources; provides the unique service of disseminating current and emerging data in response to specific healthcare professional inquiries; and delivers expert disease-state and technical product education.
  • Understands and balances clinical objectives with Prolong Pharma business priorities creating a positive impact on product utilization, product innovations, and growth. The Sr. MSL does so by serving on Prolongs Pharma cross-functional teams as a conduit for accurate and updated medical-scientific information, medical-scientific intelligence, emerging clinical trends, and customer feedback.
  • Provides internal Prolong Pharma stakeholders with a scientific foundation and expert medical-scientific resource with which to optimize their performance through the development and execution of targeted individual and group disease-state and product education initiatives.
  • Fulfills project team leadership roles on select internal and external projects.
  • Position reports to the CEO/CSO.
  • Directed cross-functional teams to enhance product development timelines and improve overall efficiency.
  • Implemented strategic initiatives that increased operational effectiveness and streamlined processes across departments.

Medical Science Liaison-Critical Care/Coagulation

CSL-Behring
08.2008 - 09.2014
  • Leads and coordinates in the global strategic development and implementation around the utilization of Riastap, the first and only Fibrinogen Concentrate, to US Commercial Operations, CSL Behring for use in Cardiac Surgery, Trauma and GI and our 4-Factor prothrombin complex concentrate (4 F-PCC) now approved for the urgent reversal of vitamin K antagonist (i.e warfarin) therapy in patients with acute major bleeding and need for urgent surgery/invasive procedure.
  • Generates and manages strong KOL relationships through the long-term management of these KOL and key external customer relationships for sustainable advocacy and company reputation as a scientifically-innovative industry partner.
  • Maintains comprehensive medical-scientific knowledge of assigned therapeutic areas, disease states, and evolving clinical issues related to CSLB products, through literature surveillance and attendance at scientific meetings to: Learn, interpret, and convey pertinent scientific data and evaluate new information, assess the impact on CSL Behring business, and navigate brand initiatives towards appropriate research and clinical utilization of products.
  • Facilitates the intake and evolution of unsolicited investigator-initiated trial (IIT) ideas to feasible and meaningful protocols, providing medical-scientific data to expand areas of product use and development, as well as the process of protocol approval. Manages, monitors, and communicates IIT study activity progress to meet established budgets and timelines.
  • Interprets and develops timely, focused responses to external and internal requests for medical-scientific information (including compliant dissemination of unsolicited requests for off-label information) regarding CSL Behring products.
  • Serves as a central reliable resource for education and dissemination of pertinent, clear, and balanced medical-scientific information to internal audiences (Brand teams, National Accounts Department, Medical Affairs, Pharmacovigilance, Reimbursement, Research & Development, and Sales) and external audiences (healthcare professionals, consumers, patient organizations, distributors, etc.). Represents the medical-scientific perspective during respective cross-functional brand-planning strategy meetings; contributes to the development and refinement of CSL Behring business initiatives, and aligns KOL interactions with successful implementation and achievement of franchise goals.
  • Contributes an expert clinical perspective on the identification and integration of influential participants in the Speaker's Bureau and Advisory Board Committees. Contributes clinical-scientific recommendations and insight to external vendors to ensure accurate representation of the company, products, and supporting science.
  • Provides scientific scrutiny of therapeutic initiatives (i.e. publications, educational programs, market research, and other requested materials) for assigned therapeutic areas and products to ensure information to health care providers is accurate, detailed, and balanced.
  • Coordinates and executes professional education, consultant programs, and one-to-one peer exchange, as well as expert product training, to internal and external audiences in specific therapeutic areas, involving highly-complex therapies.

Consultant - Business Development

ADS Biotechnology
06.2010 - 04.2012
  • Company Overview: (Pre-Clinical Start-up)
  • Serve as a key consultant of the executive team that sets the company's strategic direction around partnership and strategic licensing opportunities in support of our Peg-Albumin drug development program.
  • Support Business Development activities including in-licensing, out-licensing, development planning and commercial forecasts/valuations as needed.
  • Utilize ADS resources (journals, external databases, reports, access to scientific staff) and external resources (interviews with academic scientific leaders) to refine ADS in-licensing opportunity pipeline.
  • Key Liaison for strategic partnerships development and management and funding opportunities through extensive research and profiling.
  • Win early customers with limited support.
  • Be the driving force in the development of the work ethic, culture and values of the business development group. Through personal example, establish the style and approach which will characterize the Company's dealings with the marketplace.
  • (Pre-Clinical Start-up)
  • Led cross-functional teams to implement innovative biotechnology solutions, enhancing project outcomes.
  • Developed and executed strategic plans for product development, aligning with market needs and trends.

Medical Liaison-Hemostasis

Novo Nordisk Inc.
03.2006 - 08.2008
  • Provide comprehensive support of marketed and development biopharmaceutical products, in particular NovoSeven within a specified geographic area of the country.
  • Serves as the scientific resource for health care providers (HCP's) and other NNI employees, as required.
  • Provide support to HCP's for publications that relate to current areas of scientific interest.
  • Attend assigned medical and scientific meetings to: respond to inquiries from the medical community, address current scientific issues and new data pertaining to NNI products.
  • Establish and maintain a functional working relationship with Clinical and Clinical Research Associates working within the Region supporting clinical research directives.
  • Develop formulary presentations.
  • Design, develop and deliver presentations to individuals and groups of strategic importance to NNI.
  • Support field medical education initiatives in line with the current licensed products and research activities.
  • Coordinate customer feedback with respect to sponsored medical education events or needs.
  • Identify, respond to inquiries and develop relationships with health care providers; identifying those individuals with novel research concepts, clinical experience and expertise, within identified therapeutic areas or the use of NNI products.
  • Develop and demonstrate a thorough working knowledge of NNI, its products, current scientific research and publications associated with same.
  • Develop and/or maintain a pool of high quality regional participants for advisory meetings.
  • In conjunction with Drug Development, contact influential centers and investigators to initiate and/or participate in clinical trials and identify key areas of future research.
  • Consistently complete administrative duties in an accurate manner and on a timely basis, in line with current SOP's and working practices.
  • Communicate activity through timely submission of reports and highlights.

Clinical Training Coordinator

Terumo Heart Inc.
04.2005 - 01.2006
  • Primary interface is with the Clinical Study Team and includes interfacing with representatives from functional groups including Research and Development, Product Development, Manufacturing, Marketing, Distribution, Regulatory Affairs, outside consultants.
  • Develop and implementation of clinical/technical material and training for investigators center staff and Terumo Heart, Inc. field clinical team.
  • Clinical/technical support to THI project teams, customers and field teams via training, attendance at implants or follow ups, call support, including on call coverage as needed.
  • Active participation in cross functional teams such as the complaint handling and design enhancement teams.
  • Review clinical data/information and contribute to data correction and report to Clinical Study Team. Primarily the technical data and issues for interface throughout the key functional groups.
  • Assists Clinical Study team in providing interim and final reports and presentations.
  • Developed budgets and project plans.
  • Review and approve center activation documentation in collaboration with Clinical Study Team.
  • Attended relevant scientific and medical meetings.

Clinical Support Consultant

SynCardia Systems
11.2004 - 04.2005
  • Company Overview: (Start-up)
  • Initiated and executed 24/7 clinical support to select Transplant Centers utilizing the Cardiowest Implantatable temporary Total Artificial Heart throughout the Midwest, East Coast and Eastern Canada. Assist Physicians, Nurses, Perfusionist and VAD Coordinators in patient management on the TAH-t.
  • Was a resource and assisted the Physicians, Nurses, Perfusionist and VAD Coordinators in patient management on the TAH-t.
  • Assisted in the three phase FDA mandated training of the Transplant Center's certification for implant readiness.
  • Responsible for periodical reeducation of the Transplant Team on the Patient Simulator.
  • Provide support in the updating of the training material and technical assistance with the Sales Force.
  • Provide assistance to BioMed Dept in troubleshooting equipment.
  • Attend medical seminars and other social functions that promote the company.
  • This position reports to the Senior VP Clinical Support.
  • (Start-up)

Dept. of Perfusion, Clinical Education Coordinator

Toledo Hospital
06.2002 - 11.2004
  • Managed and coordinated mechanisms to ensure the personnel of Surgery and Critical Care Department are brought up to date on new technologies and techniques. Attended medical, research, and new technique conferences. Developed and implemented continuing education in-services for the personnel.
  • Provided in-services for CV, Anesthesia and Critical Care physician and nurses on the updated Perfusion Techniques and Practices.

Staff Clinical Cardiovascular Perfusionist

Toledo Hospital
02.1996 - 11.2004
  • Performed extensive pre and post operative patient work-up in preparation for surgery.
  • Managed the open heart surgical patients utilizing the heart-lung machine, providing complete cardio-pulmonary support during operation and assisted the Anesthesiologist with post-operative homeostasis.
  • Managed and coordinated Blood Conservation nurses working within the (Auto transfusion) Blood Services Department.
  • Recognized by peers for successfully introducing and increasing awareness for Blood Conservation Practices within the department.
  • Served on Blood Use/Utilization Review Committee 1997-2004.
  • Served on Bloodless Surgery Committee 1998-2005.
  • Proficient in the use of Sarns 8000 Heart-Lung machine, Quest MPS Microplegia machine, Medtronic Magellan, biomedicus Pump, and Cobe Brat.
  • Operated cardiopulmonary bypass machines during surgical procedures, ensuring optimal patient care and safety.
  • Collaborated with surgical teams to develop and implement perfusion protocols tailored to individual patient needs.
  • Employed specialized procedural knowledge and equipment to test and document patient cardiac activity.

Education

Master of Science - Master of Science Equivalency, Clinical Cardiovascular Perfusion Science

Johns Hopkins Hospital, School of Perfusion Sciences
Baltimore, MD
01.1995

B.S. - Biology Pre-Medicine, Minor Analytical Chemistry

Oakwood College
Huntsville, AL
01.1992

Skills

  • Interpersonal skills
  • Operations management
  • Executive support
  • Customer-oriented
  • Team leadership
  • Motivation
  • Team player
  • Staff training
  • Public speaking talent
  • Staff motivation

Timeline

Executive/Sr Medical Science Liaison

Terumo Medical
05.2022 - 09.2025

Executive Consultant

BusStim LLC
05.2019 - 2020

Oncology Executive Medical Science Liaison

Coherus Biosciences
02.2019 - 07.2020

Senior/Executive Medical Science Liaison

Prolong Pharmaceuticals
09.2014 - 05.2018

Consultant - Business Development

ADS Biotechnology
06.2010 - 04.2012

Medical Science Liaison-Critical Care/Coagulation

CSL-Behring
08.2008 - 09.2014

Medical Liaison-Hemostasis

Novo Nordisk Inc.
03.2006 - 08.2008

Clinical Training Coordinator

Terumo Heart Inc.
04.2005 - 01.2006

Clinical Support Consultant

SynCardia Systems
11.2004 - 04.2005

Dept. of Perfusion, Clinical Education Coordinator

Toledo Hospital
06.2002 - 11.2004

Staff Clinical Cardiovascular Perfusionist

Toledo Hospital
02.1996 - 11.2004

B.S. - Biology Pre-Medicine, Minor Analytical Chemistry

Oakwood College

Master of Science - Master of Science Equivalency, Clinical Cardiovascular Perfusion Science

Johns Hopkins Hospital, School of Perfusion Sciences

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