MARTINA DAELLI
Lunenburg,MA
Summary
Scientist with 5+ years of experience in both the R&D Discovery and CMC space. A proven track record of using my excellent personal, communicational, and organizational skills to lead research projects from start-to-finish, improve and innovate manufacturing processes in the PD-CMC space and collaborating with MS&T teams for successful Tech Transfers. Committed to advancing biomedical research from an immunological perspective. Team player with excellent communication skills, high quality of work, driven and highly self-motivated to rise to new challenges.
Skills
TCRT-T cells production
CAR-T cells production
CAR-NK cells production
Cell Line Development
Multicolor Flow Cytometry
Cell-Based Assay Development
Non-Viral cell engineering
T cell Metabolism (Seahorse)
CliniMACS, CliniMACS Prodigy Systems
G-REX Systems
Thermofisher large-scale systems
Tech Transfer support
Overview
5
5
years of professional experience
1
1
year of post-secondary education
Work History
Scientist II, Process Sciences
Affini-T Therapeutics
Watertown, MA
11.2023 - 08.2024
- Led a project to identify, screen and implement a new media formulation option for developing a non-viral TCR-T manufacturing process using frozen starting material.
- Investigated mechanism of action of TCR-T drug candidate’s metabolism in response to different metabolic stressors using Seahorse XFPro and Seahorse HS-mini assays.
- Led a team of 2 to validate and characterize 10+ small- and 8 large-scale productions of non-virally engineered TCR-T cells using flow cytometry and metabolite analysis via FLEX2.
- Validated and characterized one at manufacturing scale productions of TCR-T cells to solidify Tech Transfer package to CDMO.
- Aided in the Tech Transfer of the lead program to CDMO by establishing and overseeing training of CDMO's staff on key process procedures, supporting the MS&T team.
- Enhanced efficiency and accuracy of material management by implementing an electronic inventory and tracking solution.
- Managed PD team's operations, including budgeting, purchasing equipment, and maintaining a safe work environment.
Scientist I, Cell Therapy
SalioGen Therapeutics
Lexington, MA
07.2022 - 11.2023
- Lead scientist on the CAR-NK project.
- Spearheaded all the efforts to develop a strong NK cell growth and expansion pipeline.
- Created and developed SOPs for all NK cell-based assays.
- Created and enhanced transposon-based engineering method for the production of engineered CAR-NK cells.
- Developed and implemented new SOPs to characterize and immunophenotype engineered NK cells.
- Designed plasmids for the CAR-NK project.
- Assisted in conducting cell-based plasmid screenings for the solid tumor program involving CAR-T and CAR-NK applications.
Scientist I, Cell Therapy
Glyde Bio Inc.
Cambridge, MA
01.2021 - 07.2022
- Optimized and streamlined assays used to characterize our lead product’s effects on target and off-target cells via flow cytometry methodology.
- Screened our proprietary monoclonal antibodies against various cancer cells lines for binding specificity and complement dependent killing.
- Developed and implemented new SOPs to optimize the flow cytometry assays.
- Maintained CACO2, SNUC5, Jurkats, and HELA cell lines.
- Ensured smooth execution of the GLP-Toxicology study by coordinating operations with our CRO.
- Led a team consisting of three Co-op students and one Research Associate, offering mentorship and managing their progress.
- Contributed to the improvement of mRNA development through optimization of mini, midi, and maxi prep assays.
Research Associate, Platform Immunology
Moderna Inc.
Cambridge, MA
03.2020 - 12.2020
- Assessed mRNA expression in immune cell subsets via in vivo and in vitro assay analysis
- Worked with murine, rat, and non-human primate (NHP) tissues to develop and optimize 15 colors flow cytometry panels
- Optimized flow cytometry SOPs to immunophenotype cell subsets to ascertain which cells are targeted by mRNA-LNPs.
Research Associate, T cell Process Development
TCR2 Therapeutics
Cambridge, MA
09.2019 - 03.2020
- Optimized closed-system cell therapy process of TCR2’s first T cell product (TRuC) while minimizing processing complexity and costs
- Developed a successful closed process to produce TRuC product comparable to that of current process
- Proficient usage of CliniMACS Prodigy and G-REX systems for T cell engineering and expansion.
Education
Master of Science - Immunology and Immunotherapy
University of Birmingham
2018.08 - 2019.09
Bachelor of Science - Biology
University of Massachusetts
Boston, MA05.2018
Languages
Italian
Native/ Bilingual
References
References available upon request.
Timeline
Scientist II, Process Sciences
Affini-T Therapeutics
11.2023 - 08.2024
Scientist I, Cell Therapy
SalioGen Therapeutics
07.2022 - 11.2023
Scientist I, Cell Therapy
Glyde Bio Inc.
01.2021 - 07.2022
Research Associate, Platform Immunology
Moderna Inc.
03.2020 - 12.2020
Research Associate, T cell Process Development
TCR2 Therapeutics
09.2019 - 03.2020
Master of Science - Immunology and Immunotherapy
University of Birmingham
2018.08 - 2019.09
Bachelor of Science - Biology
University of Massachusetts
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