Md Motiar Rahman

Involved research projects:

1. Functional and gene expression control of SARS-CoV-2 RNA structure using triplex-forming peptide nucleic acids (PNAs)

2. Study the binding affinity of chemically modified PNAs with various bulge RNAs in vitro through chemical probing (DMS and SHAPE) and gel shift assay

3. Application of chemically modified CRISPR RNA (crRNAs) that assist Cas9 protein to mediate genome editing in humans cell lines and the subsequent analyses of the off-target effect using GuideSeq

4. In situ mutation detection of extracellular vesicles DNA using CRISPR probe loaded liposome

Articles

1. Md Motiar Rahman et al., Peptide nucleic acids (PNAs) control the frameshifting efficiency of the SARS-CoV-2 genome through RNA-PNA complex formation (In press)

2. Christopher A. Ryan, Md Motiar Rahman, Vipin Kumar, and Eriks Rozners, Triplex-forming peptide nucleic acid controls dynamic conformations of RNA bulges, Journal of the American Chemical Society, 145 (2023) 10497-10504.

3. Md. Mofizur Rahman, Lixue Wang, Md. Motiar Rahman et al., Yuan Wan, Rapid in situ mutation detection in extracellular vesicle-DNA, bioRxiv, https://doi.org/10.1101/2024.02.26.582068.

Involved Research Projects:

1. Development and optimization of mRNA to use as therapeutic cancer vaccines

2. Functional analysis of long non-coding RNA (lnRNA) in silico that contribute to triple-negative breast cancer in humans

Articles

1. Md Motiar Rahman et al., Identification of long non-coding RNA candidates that contribute to triple-negative breast cancer in humans through the computational method, International Journal of Molecular Sciences 22 (2021) 12359.

2. Md. Motiar Rahman et al., Jiandong Huang, An overview on the development of mRNA-based vaccines and their formulation strategies for improved antigen expression, Vaccines 9 (2021) 244.

Involved research projects:

1. Biochemical analysis of long-range tertiary interacting motifs and their application to RNA nanostructure design

2. Analysis of the effects of core separation ofthe Tetrahymena group I ribozyme and their application to construct RNA one-dimensional array

3. Analysis of the effects of polyethylene glycol (PEG) to restore the catalytic activity of structurally unstable ribozyme systems

4. Biochemical analyses of structurally unstable RNA enzyme (ribozyme) with natural polyamines

Articles

1. Md Dobirul Islam, Md Motiar Rahman et al., Effects of chain length of polyethylene glycol molecular crowders on a mutant Tetrahymena group I ribozyme lacking large peripheral module, Nucleosides, Nucleotides and Nucleic Acids 17 (2021) 867-883.

2. Md. Motiar Rahman et al., Effect of molecular crowding on a bimolecular group I ribozyme and its derivative that self-assembles to form ribozyme oligomers, Biochemical and Biophysical Research Communications 507 (2018) 136-141.

3. Md. Motiar Rahman et al., Oligomerization of a bimolecular ribozyme modestly rescues its structural defects that disturb the interdomain assembly to form the catalytic site, Journal of Molecular Evolution 86 (2018) 431-442.

4. Mst A Gulshan, Md. Motiar Rahman et al., Biogenic triamine, and tetraamine activate the core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module, Biochemical and Biophysical Research Communications 496 (2018) 594-600.

5. Md. Motiar Rahman et al., Artificial RNA motifs expand programmable assembly between RNA modules of a bimolecular ribozyme leading to application to RNA nanostructure design, Biology 6 (2017) 37.

Involved research projects:

1. Design of short-length DNA (label-free) biomarkers for the detection of food adulterants in the mixed biological samples based on multiplex PCR

2. Synthesis of mesoporous carbon-supported gold catalysts for alkylbenzene oxidation

Article

1. Md. Eaqub Ali, Md. Motiar Rahman et al., Heterogeneous metal catalysts for oxidation reaction-A review, Journal of Nanomaterials 2014 (2014) 23.

Job Responsibility:

1) Investigating Biochemical, Molecular, and Immunological test of different types of samples provided by the patients

2) Interpreting and recording data and presenting to the consultants/doctors

3) To perform and monitor Quality Control (QC) and calibration of equipment and update all the records accordingly