Summary
Overview
Work History
Education
Skills
Conference Presentations
Leadership And Community Service
Selected Publications
Honors And Awards
Timeline
Generic

Mingyue Li

Andover

Summary

Principal Scientist at Pfizer with 4 years of experience in biotherapeutics and vaccine development. Authored over 25 publications, and developed innovative analytical technologies to drive impactful research in various therapeutic areas. Expertise in leading technology innovation in analytical R&D.

Overview

18
18
years of professional experience

Work History

Senior Scientist - Principal Scientist

Pfizer
Andover
08.2021 - Current
  • Led the Technology & Innovation cross-functional team to evaluate innovation efforts in automation, mRNA technologies, enhancing platform technologies, and attribute understanding & control.
  • Heightened characterization lead for biotherapeutics and vaccine development
  • Subject matter expert in analytical and biophysical techniques.
  • Corresponding author of multiple publications.

Postdoctoral Fellow

Merck & Co. Inc.
West Point
09.2019 - 07.2021
  • Authored over 10 publications in high-profile pharmaceutical and chemistry journals on structure and formulation characterization of small molecule, LNP structure, lyophilized vaccines and biologics.

Postdoctoral Associate

University of Pittsburgh School of Medicine
Pittsburgh
10.2016 - 08.2019
  • Authored 2 publications on the structure and dynamics of membrane-bound cytochrome c, implicated in mitochondrial apoptosis.
  • Authored one publication on the aggregation mechanisms of gD-crystallin implicated in cataract formation.

Graduate Research Assistant

University of Delaware
Newark
01.2011 - 01.2016
  • Characterized the conformation and dynamics of Tau, an Alzheimer’s disease related protein, upon binding to polymeric microtubules
  • Investigated the structure and dynamics of human motor protein kif5b assembled with microtubules
  • Developed a structural characterization method for oxovanadium (V) bioinorganic compounds by a hybrid of multinuclear MAS NMR spectroscopy and DFT calculations

Undergraduate Research Assistant

Jilin University
Changchun
01.2008 - 01.2010
  • Contributed to the method development of silver nanoprisms synthesis

Education

Ph.D. - Chemistry and Biochemistry

University of Delaware
Newark, DE
01.2016

B.S. - Chemistry

Jilin University
Changchun, Jilin, China
01.2010

Skills

  • Analytical techniques
  • Biophysical methods for proteins and particles
  • Circular dichroism (CD)
  • Dynamic light scattering (DLS)
  • Infrared spectroscopy (IR)
  • Differential scanning calorimetry (DSC)
  • UV-Vis spectroscopy
  • Fluorescence spectroscopy
  • Mass photometry
  • Size exclusion chromatography with multi-angle light scattering (SEC-MALS)
  • AUC
  • UPLC, HPLC, FPLC
  • LC/MS
  • Transmission electron microscopy (TEM)
  • SDS-PAGE
  • Solution NMR techniques
  • Solid-state NMR techniques
  • Statistical analysis tools
  • JMP software
  • OriginLab software
  • PRISM software

Conference Presentations

  • Poster presentation at CASSS HOS, Chicago, IL, 09/01/23
  • 2020 AAPS PharmSci 360 Symposium, Virtual, 10/01/20
  • 33rd Protein Society Symposium, Seattle, WA, 06/01/19
  • 14th Postdoctoral Data & Dine Symposium, Pittsburgh, PA, 05/01/19
  • 7th Molecular Biology & Structural Biology Research Symposium, Pittsburgh, PA, 05/01/19
  • 60th Experimental Nuclear Magnetic Resonance Conference, Asilomar, CA, 04/01/19
  • 3rd Gateway NMR Conference, Pittsburgh, PA, 11/01/18
  • 2nd Gordon Research Conference on Molecular Structure Elucidation, Newry, ME, 08/01/18
  • 6th Molecular Biology & Structural Biology Research Symposium, Pittsburgh, PA, 05/01/18
  • 59th Experimental Nuclear Magnetic Resonance Conference, Orlando, FL, 04/01/18
  • 2nd Gateway NMR Conference, Columbus, OH, 11/01/17
  • 5th Molecular Biology & Structural Biology Research Symposium, Pittsburgh, PA, 05/01/17
  • 12th Postdoctoral Data & Dine Symposium, Pittsburgh, PA, 05/01/17
  • 57th Experimental Nuclear Magnetic Resonance Conference, Pittsburgh, PA, 04/01/16
  • 43rd Silver Symposium, University of Delaware, Newark, DE, 05/01/15
  • 55th Experimental Nuclear Magnetic Resonance Conference, Boston, MA, 04/01/14
  • 54th Rocky Mountain Conference on Magnetic Resonance, Cooper Mountain, CO, 08/01/12

Leadership And Community Service

  • Scientific Committee Member, CASSS HOS, 2024 -
  • Journal reviewer, Scientific Reports, Biochemical Society Transaction, Communications Biology, Biophysical Chemistry, Chemistry and Physics of Lipids, Biomedicine & Pharmacotherapy, ChemPhysChem
  • Member, American Association of Pharmaceutical Scientists, 2020 – 2022
  • Member, Merck Postdoctoral Association, 2019 – 2021

Selected Publications

  • Molecular Insight into Lipid Nanoparticle Assembly From Solution and Solid-state NMR Spectroscopy, Li, M., etc, 2025, Mol. Pharmaceutics
  • Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches, Li, M., etc, 2024, Mabs, 16, 1, 2292688
  • Molecular mechanism of antimicrobial excipient-induced aggregation in parenteral formulations of peptide therapeutics, Li, M., etc, 2022, Mol. Pharmaceutics, 19, 9, 3267–3278
  • Understanding the Impact of Protein–Excipient Interactions on Physical Stability of Spray-Dried Protein Solids, Chen, Y., Ling, J., Li, M., Su, Y., etc, 2021, Mol. Pharmaceutics, 18, 7, 2657–2668
  • Investigating crystalline protein suspension formulations of pembrolizumab from MAS NMR spectroscopy, Li, M., etc, 2022, Mol. Pharmaceutics, 19, 3, 936–952
  • Activation of Cytochrome C Peroxidase Function Through Coordinated Foldon Loop Dynamics upon Interaction with Anionic Lipids, Li, M., etc, 2021, J. Mol. Biol., 443, 15, 167057

Honors And Awards

  • American Association of Pharmaceutical Scientists Best Poster Abstract Award, Virtual, 11/01/20
  • Hans Neurath Outstanding Promise Travel Award, 33rd Protein Society Symposium, Seattle, WA, 06/01/19
  • Professional Opportunities for Women Travel Award, 62nd Biophysical Society Meeting, San Francisco, CA, 02/01/18
  • Professional Development Award for Graduate Students, University of Delaware, Newark, DE, 12/01/16
  • Student Travel Award, 55th Experimental Nuclear Magnetic Resonance Conference, Boston, MA, 04/01/14
  • Outstanding Student Fellowship, Jilin University, Changchun, Jilin, 01/01/09
  • Outstanding Student Fellowship, Jilin University, Changchun, Jilin, 01/01/08
  • Outstanding Student Fellowship, Jilin University, Changchun, Jilin, 01/01/07

Timeline

Senior Scientist - Principal Scientist

Pfizer
08.2021 - Current

Postdoctoral Fellow

Merck & Co. Inc.
09.2019 - 07.2021

Postdoctoral Associate

University of Pittsburgh School of Medicine
10.2016 - 08.2019

Graduate Research Assistant

University of Delaware
01.2011 - 01.2016

Undergraduate Research Assistant

Jilin University
01.2008 - 01.2010

Ph.D. - Chemistry and Biochemistry

University of Delaware

B.S. - Chemistry

Jilin University

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