Naritaka Tamaoki

Results-driven leader with strong background in strategic management and organizational growth. Skilled in developing and implementing effective business strategies, optimizing processes, and driving team performance. Known for adaptability, effective collaboration, and delivering measurable outcomes in dynamic environments. Strong communication and problem-solving abilities, coupled with focus on fostering productive and positive team culture.

• Rejuvenation of human T cells with a partial reprogramming
• Evaluation of T cell cytotoxic capacity using CD19-CAR and NY-ESO models
• Multi-color flow cytometry analysis and cell sorting with Sony sorter
• Generation of human and mouse iPSCs from PBMC-derived T cells and tumor-infiltrating lymphocytes (TILs)
• Characterization of human iPSC (EB-based differentiation, Teratoma assay, Bisulfite sequencing analysis of OCT3/4 and NANOG methylation in iPSC)
• Human iPSC differentiation to hematopoietic progenitor/stem cells and T cells
• Gene introduction into human somatic cells using retroviral, lentiviral, and Sendai virus systems

• METHODS FOR MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING REJUVENATED T CELLS, US12091682, 09/17/24
• METHODS FOR MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING REJUVENATED T CELLS, WO2022115492A1, 11/24/20, 11/23/21, 06/02/22
• PREFERENTIAL GENERATION OF IPSC CARRYING ANTIGEN SPECIFIC TCRs FROM TUMOR SPECIFIC TCRs, WO2022040569A1, 08/21/20, 08/20/21, 02/24/22
• METHODS OF PRODUCING POPULATIONS USING PLURIPOTENT STEM CELLS, WO2021142081A1, 01/07/20, 01/07/21, 07/15/21
• METHODS OF PREPARING HEMATOPOIETIC PROGENITOR CELLS IN VITRO, WO2019/094614A1, 11/08/17, 11/08/18, 05/16/19
• EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS (INCLUDING DLX4), WO2015/030111A1, PCT/JP2014/072564, 08/28/14, 03/05/15
• EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS, WO2010/013359A1, 07/31/08, 10/02/08, 08/05/14, 08/05/14

• 2012, William J. Gies Award, IADR/AADR
• 2009, MEDARTIS Award, Japanese Society of Oral and Maxillofacial Surgeons

• Tamaoki N, Siebert S, Maeda T, Ha NH, Good ML, Huang Y, Vodnala SK, Haro-Mora JJ, Uchida N, Tisdale JF, Sweeney CL, Choi U, Brault J, Koontz S, Malech HL, Yamazaki Y, Isonaka R, Goldstein DS, Kimura M, Takebe T, Zou J, Stroncek DF, Robey PG, Kruhlak MJ, Restifo NP, Vizcardo R., Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells., Cell Rep Methods, 04/24/23, 3, 4, 100460
• Tamaoki N, Takahashi K, Aoki H, Iida K, Kawaguchi T, Hatakeyama D, Inden M, Chosa N, Ishisaki A, Kunisada T, Shibata T, Goshima N, Yamanaka S, Tezuka K., The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells., Sci Rep, 12/04/14, 4, 7283
• Tamaoki N, Takahashi K, Tanaka T, Ichisaka T, Aoki H, Takeda-Kawaguchi T, Iida K, Kunisada T, Shibata T, Yamanaka S, Tezuka K., Dental pulp cells for induced pluripotent stem cell banking., J Dent Res, 08/01/10, 89, 8, 773-8
• Islam SMR, Maeda T, Tamaoki N, Good ML, Kishton RJ, Paria BC, Yu Z, Bosch-Marce M, Bedanova NM, Liu C, Kruhlak MJ, Restifo NP, Vizcardo R., Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells., Cancer Res Commun, 05/25/23, 3, 5, 917-932
• Selami Demirci, Juan J Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P Restifo, John F Tisdale, Naoya Uchida., Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation., Stem Cell Res Ther, 11/24/20, 11, 1, 493
• Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP., Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System., Cell Rep, 03/20/18, 22, 12, 3175-3190
• Sugiyama K, Nagashima K, Miwa T, Shimizu Y, Kawaguchi T, Iida K, Tamaoki N, Hatakeyama D, Aoki H, Abe C, Morita H, Kunisada T, Shibata T, Fukumitsu H, Tezuka KI., FGF2-responsive genes in human dental pulp cells assessed using a rat spinal cord injury model., J Bone Miner Metab, 09/05/18
• Nagashima K, Miwa T, Soumiya H, Ushiro D, Takeda-Kawaguchi T, Tamaoki N, Ishiguro S, Sato Y, Miyamoto K, Ohno T, Osawa M, Kunisada T, Shibata T, Tezuka KI, Furukawa S, Fukumitsu H., Priming with FGF2 stimulates human dental pulp cells to promote axonal regeneration and locomotor function recovery after spinal cord injury., Sci Rep, 10/18/17, 7, 1
• Eiji Naito, Daichi Kudo, Shin-Ichiro Sekine, Kazuhiro Watanabe, Yui Kobatake, Naritaka Tamaoki, Masatoshi Inden, Kazuki Iida, Yusuke Ito, Isao Hozumi, Toshiyuki Shibata, Sadatoshi Maeda, Takeda-Kawaguchi T, Sugiyama K, Chikusa S, Iida K, Aoki H, Tamaoki N, Hatakeyama D, Kunisada T, Shibata T, Fusaki N, Tezuka K., Derivation of iPSCs after Culture of Human Dental Pulp Cells under Defined Conditions., PLoS One, 12/18/14, 9, 12
• K.Iida, T.Takeda-Kawaguchi, M.Hada, M.Yuriguchi, H.Aoki, N.Tamaoki, D.Hatakeyama, T.Kunisada, T.Shibata, K.Tezuka., Hypoxia-enhanced derivation of iPSCs from human dental pulp cells., J Dent Res, 10/01/13, 92, 10, 905-10
• THE CELL, 51, 4, 2019, Takuya Maeda, Meghan Good, Naritaka Tamaoki, Nicholas Restifo, Raul Vizcard
• Standard Protocol on Organoids, 2019, Raul Vizcard, Takuya Maeda, Rafiqul Islam, Naritaka Tamaoki, Nicholas Restifo