Nazia Nazam
Birmingham
Summary
Accomplished postdoctoral fellow specializing in pediatric oncology with a strong background in chemoresistance and oncogenic drivers in solid tumors. Investigated the role of protein phosphatase 2A (PP2A) in pediatric cancers, demonstrating therapeutic potential through novel small molecule activators. Focused on elucidating molecular and epigenetic factors contributing to disease relapse and developing preclinical evidence for PP2A reactivation strategies. Dedicated to bridging research and clinical practice to improve treatment options and quality of life for patients with solid tumors.
Overview
15
15
years of professional experience
Work History
Post-doctoral Fellow
University of Alabama at Birmingham
Birmingham
10.2022 - Current
- Company Overview: Department of Pediatric Surgery, School of Medicine, University of Alabama at Birmingham, USA.
- Evaluate the epigenetic changes associated with activation of the PP2A tumor suppressive pathway in neuroblastoma and other pediatric solid tumors
- Department of Pediatric Surgery, School of Medicine, University of Alabama at Birmingham, USA.
Post-doctoral Research Associate
Amity University Uttar Pradesh
Noida
12.2020 - 09.2022
- ICMR RA: Deciphering therapeutic potential of an epigenetic target in ovarian tumorigenesis and drug resistance
Senior Research Fellow
Amity University Uttar Pradesh
Noida
10.2019 - 12.2020
- DBT project: Understanding epigenetic regulation of chemoresistance pathways in ovarian cancers to develop new therapeutic approaches
Research Assistant
Amity University Uttar Pradesh
Noida
02.2018 - 10.2019
- DBT RLS: Identifying new cancer drivers and exploring their transcriptional regulation in ovarian cancers to develop new therapeutic approaches
Ph.D. University Fellowship; Senior Research Fellow
Aligarh Muslim University
Aligarh
01.2015 - 01.2018
- DNA damage and biochemical alteration in mammalian tissues exposed to organophosphate compounds: possible amelioration by phytoextract
Junior Research Fellow
Aligarh Muslim University
Aligarh
01.2010 - 01.2012
- Dichlorophos-mediated hematopoietic organ genotoxicity in Mus musculus.
Education
Ph.D. - Genetics
Aligarh Muslim University
Aligarh, India01.2018
M.Phil - Genetics
Aligarh Muslim University
Aligarh, India05.2012
M.Sc. - Genetics
Aligarh Muslim University
Aligarh, India06.2009
B.Sc. (Hons.) - Zoology
Aligarh Muslim University
Aligarh, India06.2007
Senior Secondary (Class XII) -
Aligarh Muslim University
Aligarh, India06.2003
Higher Secondary (Class X) -
D.A.V Public School
Jharkhand, India04.2001
Skills
- Cell culture
- In vivo cytogenetic assays
- Molecular techniques
- Biochemical assays
- Microscopy
- Experimental Models
- Animal and cell line handling
- Routine culturing and maintenance
- Cell viability
- Wound healing assay
- Migration & invasion assay
- Clonogenic assay
- Cell Titer proliferation assay
- ELDA
- Micronucleus test
- Metaphase chromosome preparation
- Mitotic index
- Sperm morphology assay
- Comet assay
- DNA extraction
- RNA extraction
- Protein extraction
- Quantification
- Gel profiling
- Immunoblotting
- Basic PCR
- RT-qPCR
- ChIP-qPCR
- SiRNA-based gene knockdown
- Flow cytometry
- Cell cycle analysis
- Cell death analysis
- MMP analysis
- Basic cloning
- Gene overexpression
- ELISA
- Antioxidant markers
- Oxidative stress markers
- Hepatic marker enzyme
- Renal marker enzyme
- Histopathological preparation
- H & E staining
- Immunohistochemistry
- Orthotopic model
- Flank model
- Athymic nude mice
- NOD-SCID mice
- Wistar rats
- Swiss albino mice
- Cancer PDXs
- Neuroblastoma cell line
- Ovarian cancer cell line
- Breast cancer cell line
- Normal cell line
- Primer designing
- Kaplan-Meier plotter
- ROC plot
- Cancer database
- Biotechniques
- Experimental skills
- Tumor biology
- Molecular biology expertise
- Cell biology
- Molecular cytogenetics
- Molecular and cellular biology
Awards
- Career Enhancement award, Tutorials in Genomics & Bioinformatics: RNA-seq Analysis course at the Cold Spring Harbor Meeting, 05/11/25
- Travel award for Oral presentation, ASC, 02/06/24
- 3rd prize for Oral presentation, 2023 Postdoctoral Research Day, 10/09/23
- Best oral presentation, 41st Annual Conference of Indian Association for Cancer Research, 03/02/22
Publications
- PP2A activation targets MYCN in neuroblastoma via epigenetic regulation, Nazia Nazam et al., 2025, Experimental and Molecular Medicine, under review
- Deciphering pharmacological targets of plumbagin in cisplatin resistance ovarian cancer model using in vitro and in silico approaches, Nazia Nazam et al., 2025, Current Pharmaceutical Design, Revision stage
- PP2A activation overcomes leptomeningeal dissemination in Group 3 medulloblastoma, Nazia Nazam et al., 2024, Journal of Biological Chemistry, 300, 11, 107892
- Novel PP2A activating compounds in neuroblastoma, Nazia Nazam et al., 2024, Cancers, 16, 22, 3836
Professional Memberships
- American Society of Clinical Oncology, 7377610
- Indian Association for Cancer Research, SM/2020/0031
Research Interests
- Solid cancer
- Chemoresistance
- Therapy Induced Senescence
- Epigenetics
- DNA damage pathways
Timeline
Post-doctoral Fellow
University of Alabama at Birmingham
10.2022 - Current
Post-doctoral Research Associate
Amity University Uttar Pradesh
12.2020 - 09.2022
Senior Research Fellow
Amity University Uttar Pradesh
10.2019 - 12.2020
Research Assistant
Amity University Uttar Pradesh
02.2018 - 10.2019
Ph.D. University Fellowship; Senior Research Fellow
Aligarh Muslim University
01.2015 - 01.2018
Junior Research Fellow
Aligarh Muslim University
01.2010 - 01.2012
Ph.D. - Genetics
Aligarh Muslim University
M.Phil - Genetics
Aligarh Muslim University
M.Sc. - Genetics
Aligarh Muslim University
B.Sc. (Hons.) - Zoology
Aligarh Muslim University
Senior Secondary (Class XII) -
Aligarh Muslim University
Higher Secondary (Class X) -
D.A.V Public School
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