Nicole Sarna

Adept at pioneering cancer immunotherapy research, my tenure at Vanderbilt University honed my expertise in CAR T cell engineering and fluid shear stress analysis. Skilled in both flow cytometry and collaborative innovation, I excel in transforming scientific inquiries into tangible outcomes, evidenced by enhanced CAR T cell cytotoxicity in solid tumors.

• Sarna, N.S., Curry, N.M., Aalei, E., Kaufman, B.G., King, M.R., Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress, IEEE Reviews in Biomedical Engineering, 2023, 10.1109/RBME.2024.3505073
• King S.M.
• Sarna N.S.
• Ortiz I.
• Wang W., Lopez-Cavestany M., Zhang Z., Retention of E-Selectin Functionalized Liposome Fanny Packs on Jurkat Cells Following Invasion through Collagen, Journal of Immunological Methods, 2024, 10.1016/j.jim.2024.113700
• Sarna, N.S., Desai, S.H., Kaufman, B.G., Hanna, A.M., King, M.R., From Stress to Strength: A Kinetic Study of Enhanced and Sustained T Cell Activation and Function in Response to Fluid Shear Stress, iScience, 2023, 10.1016/j.isci.2024.109999
• Knoblauch, S.V., Desai, S.H., Dombroski, J.A., Sarna, N.S., Hope, J.M., King, M.R., Chemical and Mechanical Activation of Piezo1 Enhance TRAIL-Mediated Apoptosis in Glioblastoma Cells, ACS Omega, 2023, 10.1021/acsomega.3c00705
• Sarna, N.S.
• Marrero-Morales, L
• DeGroff, R
• Rivera-Rodriguez, A, Lui, S, Chiu-Lam, A, Good, H, Rinaldi-Ramos, CM., An anatomically correct 3D printed mouse phantom for magnetic particle imaging studies, Bioengineering & Translational Medicine, 2022, 10.1002/btm2.10299
• Dombroski, J.A.
• Hope, J.M.
• Sarna, N.S., King, M.R., Channeling the Force: Piezo1 mechanotransduction in cancer metastasis, Cells, 2021, 10.3390/cells10112815
• Rivera-Rodriguez, A, Hoang-Minh, L, Chiu-Lam, A, Sarna, N.S., Marrero-Morales, L, Mitchell, D, Rinaldi-Ramos, C.M., Tracking Adoptive T Cell Immunotherapy Using Magnetic Particle Imaging, Nanotheranostics, 2021, 10.7150/ntno.55165
• Lui, S
• Rivera-Rodriguez, A
• Chiu-Lam, A
• DeGroff, R, Savliwala, S, Sarna, N.S., Rinaldi-Ramos, C.M., Long Circulating Tracer Tailored for Magnetic Particle Imaging, Nanotheranostics, 2021, 10.7150/ntno.58548

Fluid Shear Stress for Ex Vivo Activation Of Immune Effector Cells, US 2024/0327792 A1, 10/03/24

King, MR, Hope, JM, Dombroski, JA, Sarna, NS

Co-invented a method for ex vivo activation of immune effector cells using fluid shear stress to enhance activation efficacy.