Nithyadevi Duraisamy

• Clinical trials were conducted by injecting the synthesized biopolymeric scaffolds into wistar rats through subcutaneous and studied their characterization after 14 or 21 days of reaction.
• Preclinical trials were conducted with cell culture and their characteristics were investigated using various assays (mentioned in skills)
• Conducted Fabricating nanosized biopolymeric materials using electrospinning technique, 3D imprinting, and ultrasonication methods. loading drugs and demonstrating their properties in-vitro on a regular basis.
• Used Origin, Graphpad software's to determine data-set correlations while initiating qualitative functions.
• Used MAtlab, COMSOL software's to design 3D models for 3D imprinting polymeric materials.
• Performed research into study topics to increase knowledge and to provide valuable contributions with the publications in high impact journals.
• Collaborated with staff to develop and implement best practices and accomplished all team goals.
• Streamlined research processes to meet tight deadlines for multiple projects.
• Wrote research papers, reports, reviews and summaries regarding Drug delivery, Pain management, Electrochemical properties finding with biopolymeric materials.
• Set up equipment, organized inventory and maintained facilities.

• Collaborated with JSS college of Pharmacy and KMCH college of Pharmacy (Ooty and coimbatore INDIA) professionals to advance research and gain deeper understanding of topics based on clinical trials on injecting carcinogen into rats via IV.
• Designed and carried out complex laboratory experiments to assess effectiveness of anticancer drug loaded metal/metal oxide core shell nanoparticles by four different chemical route (Stober, reflux, reverse micelle and hydrothermal method)
• The anticancer and targeting effects of stober synthesized PEG induced pure and anticancer drug (LET) loaded Ag/TiO2 core shell nanoparticles with chemically induced animal model (Xenograft studies) using SD type rats were investigated.
• Through various in-vitro analyses, developed a unique research into analyzing the anticancer and targeted properties of (Dox and LET)drug loaded (Metal/Metal oxide)core shell nanoparticles (cytotoxicity-MCF-7 cell line, hemolytic studies, Protein leakage analysis, colony count unit).
• Worked to improve collective knowledge to demonstrate the significance of materials synthesized, medication given to treat or suppress the growth of cancer cells using nanotechnology.

• Honoree of University Research Fellow
• Highly recommended dissertation
• Thesis: In- vivo and In-vitro studies on bio-compatible pure and drug loaded silver/ titanium dioxide core shell nanoparticles breast cancer therapy
• Research Project: Targeted Drug delivery Developed and troubleshooted challenging quantitative letrozole and doxorubicin (anti-cancer drug) activation formulated with Metal/metal oxide core shell nanoparticles as egg shaped structure for the development of new research focus led to suppress the growth, resulted in more than 90% of inactivation of cancer cells and release of drug from the nano compounds.
• Analyzed the biological properties of synthesized drug induced core shell nanoparticles through Female Sprague-Dawley rats with inducing breast cancer carcinoma through IV.
• Identified for the first time the mechanisms of drug induced core shell nanoparticles (Doxorubicin and letrozole) in response to cancer cell line (MCF-7) and cancer causing bacteria which led to publication in high impact journal.
• The antibacterial properties of prepared core shell nanoparticles were tested using gram positive (Stephy.cocci) bacteria through Colony count method and bacterial cytotoxicity analysis.

Thesis: Synthesis, Characterization and Photocatalytic Properties of TiO2, SnO2 and SnO2-TiO2 Composite nanoparticles

• Nanoparticles of Pure TiO2, SnO2 and SnO2 - TiO2 were synthesized by using sol-gel technique using titanium (IV)-n-butoxide and tin (II) ethylhexanate as precursors.
• The as-prepared nanoparticles are found to be amorphous while particles which are calcinated at 400 degree Celsius show a mixture of crystalline phase structure as Anatase and brookite.
• The photocatalytic activity test has been done for pure TiO2 , SnO2 and SnO2 - TiO2 nanoparticles using methylene blue solution.
• From the photo catalytic activity tests ,it is clear that pure SnO2 shows a better photocatalytic activity compared with previous reports and also with the pure TiO2 , various concentration of SnO2 - TiO2 nanoparticles due to its higher bandgap. In case of Composite , 0.4M shows higher photocatalytic activity due to less brookite presence .