Nnamdi Edokobi, Ph.D.

I am a Patent Agent with technical expertise across a broad range of life science disciplines. I value being a detail-oriented team player with strong organizational skills and being able to handle multiple projects simultaneously with a high degree of accuracy. I aspire to be a Patent Attorney, such that I can utilize my skills to develop global patent strategies for biotech, pharmaceutical companies, and academic intuitions.

Chen, C., Ziobro, J., Robinson-Cooper, L., Hodges, S. L., Chen, Y., Edokobi, N., ... & Isom, L. L. (2023). Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-linked developmental and epileptic encephalopathy. Brain Communications.

Ramos-Mondragon, R.*, Edokobi, N.*, Hodges, S. L., Wang, S., Bouza, A. A., Canugovi, C., ... & Isom, L. L. (2022). Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation. JCI insight. *RRM and NE contributed equally to this work.

Bouza, A. A., Edokobi, N., Hodges, S. L., Pinsky, A. M., Offord, J., Piao, L., ... & Isom, L. L. (2021). Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling. JCI insight.

Bouza, A. A., Philippe, J. M., Edokobi, N., Pinsky, A. M., Offord, J., Calhoun, J. D., ... & Isom, L. L. (2020). Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis. Journal of Biological Chemistry.

Edokobi, N., & Isom, L. L. (2018). Voltage-gated sodium channel β1/β1B subunits regulate cardiac physiology and pathophysiology. Frontiers in Physiology.

Sigl, V., Owusu-Boaitey, K., Joshi, P. A., Kavirayani, A., Wirnsberger, G., Novatchkova, M., Kozieradzki, I., Schramek, D., Edokobi, N., Hersl, J., Sampson, A., Odai-Afotey, A., Lazaro, C., Gonzalez-Suarez, E., Pujana, M. A., Cimba, F., Heyn, H., Vidal, E., Cruickshank, J., Berman, H., … Penninger, J. M. (2016). RANKL/RANK control Brca1 mutation. Cell Research.

Electrophysiology
Patch Clamp, Cardiomyocyte Isolation, Animal Electrocardiogram (ECG), Langendorff perfusion

Microscopy
Confocal Imaging, Whole Mount Heart Preparation, Immunohistochemistry and Immunocytochemistry

Recombinant Tissue / Organisms
Induced Pluripotent Stem Cells (iPSC) Cardiomyocytes, Cultured Eukaryotic Cells, Mouse Models, Native Tissue

Therapeutics
Small Molecules, Protein Therapeutics, Genetic Therapeutics, Antibodies, Drug Discovery, Pharmacology, Pharmacokinetics and Pharmacodynamics

Ion Channels
Ion Channel Diseases, Cardiac Arrythmia, Ion Channel Biochemistry

Molecular biology
DNA Isolation, RNA Isolation

• University of Michigan Ph.D. Connections Conference - Invited Speaker, March 2023
• University of Michigan Pharmacology in Color Symposium - Invited Speaker, June 2023
• Annual Meeting of the American Epilepsy Society - Scn1b deletion results in sinoatrial node dysfunction, atrial remodeling, and increased susceptibility to atrial fibrillation in neonates, Virtual, 2020
• Annual Meeting of the American Epilepsy Society- Characterizing SUDEP Biomarkers in SCN1B-linked Developmental and Epileptic Encephalopathy (DEE) Patient-Derived Cardiac Myocytes, Baltimore, MD, 2019
• Cardiac Arrhythmia Mechanisms Gordon Research Conference - Characterizing Sudden Unexpected Death in Epilepsy Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes, Lucca (Barga), Italy, 2019
• Examining the RANK-L Inhibitor as a Potential Targeted Therapy in Brca1 mutant mice, Annual Meeting of the American Association for Cancer Research, San Diego, CA, 2014

• Zell Lurie Institute Michigan Business Challenge, 2019 - 2020
• Eugene Applebaum Dare to Dream grant program, 2019 - 2020
• Translational Cardiovascular Research and Entrepreneurship Training Program (T32), 2019 - 2021
• Rackham Interdisciplinary Workshops, 2018
• Office of Graduate and Postdoctoral Studies Annual Graduate Student Awards - Nominee, Excellence in Promoting Diversity, Equity, and Inclusion, 2018
• Pharmacological Sciences Training Program (T32), 2017 - 2019
• Rackham Merit Fellow, 2016
• NIH MARC U STAR, 2013 - 2015
• Meyerhoff Scholar, 2013