Jenny Rudnick Weston

Director of Translational Oncology at Recursion Pharmaceuticals with specialization in oncology and immuno-oncology research. Expertise in pre-clinical drug discovery and biomarker investigation, successfully leading cross-functional teams to advance small molecule programs. Skilled in managing external collaborations and implementing efficacy assessment strategies to enhance drug development outcomes.

• Department of Defense Breast Cancer Research Postdoctoral Fellowship Award, May 2013
• American Cancer Society Postdoctoral Fellowship Award, March 2013
• NIH Institutional Research Service Award- Molecular & Cellular Mechanisms of Cancer, September 2011
• 1st place, Sackler School of Graduate Biomedical Sciences Annual Charlton Poster Competition, November 2010
• Department of Defense Breast Cancer Research Program Predoctoral Traineeship Award, April 2009
• J.W. Chappell Scholarship Recipient, Department of Chemistry, James Madison University, September 2003
• 1st place, Chemical & Biological Sciences 5th Undergraduate Research Symposium & Poster Competition, University of Maryland, Baltimore County, October 2002

• Miller, R.A., Guru, P., Bauer, P., Robles, J., Tomaszewski, C., Overcash, J.S., Waters, M., Cameron, M., Olalla Sierra, J., Janc, J., Rudnick, J.A., Hu, S., Jones, W.B., Kwei, L., Mahabhashyam, S., Willingham, S.B., Criner, G. (2021) Clinical results with a B cell activating anti-CD73 antibody for the immunotherapy of COVID-19. medRxiv
• Rudnick, J.A., Debnath, J. (2021) Autophagy in host stromal fibroblasts supports tumor desmoplasia. (2021) Autophagy, online ahead of print. PMID: 34470579
• Willingham, S.B., Criner, G., Hill, C., Hu, S., Rudnick, J.A., Daine-Matsouka, B., Hsieh, J., Mashedi, H., Hotson, A.N., Brody, J., Marron, T., Piccione, E., Buggy, J.J., Mahabhashyam, S., Jones, W.B., Mobasher, M., Miller, R.A. (2020) Characterization and phase 1 trial of a B cell activating anti-CD73 antibody for immunotherapy of COVID-19. medRxiv
• Rudnick, J.A., Monkonnen, T., Mar, F., Barnes, J.M., Starobinets, H., Goldsmith, J., Rostker, F., Roy, S., Bustamante-Eguigure, S., Weaver, V.M., Debnath, J. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. (2021) Genes Dev, 35(13-14): 963-975. PMID: 34168038
• Rudnick, J.A., Kuperwasser, C. (2012) Stromal biomarkers in breast cancer development and progression. Clin Exp Metastasis, 29(7): 663-672. PMID: 22684404.
• Rudnick, J.A., Arendt, L.M., Klebba, I., Hinds, J.W., Iyer, V., Gupta, P.B., Naber, S. P., Kuperwasser, C. (2011) Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer stem like cells. PLoS One, 6(9): e24605. PMID: 21957456.
• Fillmore, C.M., Gupta, P.B., Rudnick, J.A., Caballero, S., Keller, P.J., Lander, E.S., Kuperwasser, C. (2010) Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci, 107(50): 21737-21742. PMID: 21098263
• Keller, P.J., Lin, A., Arendt, L.M., Klebba, I., Jones, A.D., Rudnick, J.A., DiMeo, T.A., Gilmore, H., Jefferson, D.M., Graham, R.A., Naber, S.P., Schnitt, S, Kuperwasser, C. (2010) Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res, 12(5): R87. PMID: 20964822.
• Arendt, L.M., Rudnick, J.A., Keller, P.J., Kuperwasser, C. (2010) Stroma in breast development and disease. Semin Cell Dev Biol, 21(1): 11-18. PMID: 19857593.
• McCready, J. Arendt, L.M., Rudnick, J.A., Kuperwasser, C. (2010) The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis. Breast Cancer Res, 12(3): 205. PMID: 20584344.

• AACR, Chicago, IL, April 2025: “Pursuit of Novel First-In-Class Medicines with a Suite of AI-enabled Platform Technologies” (poster presentation, first author)
• AACR, Orlando, FL, April 2023: “A Phenomics Platform Combining Imaging and Artificial Intelligence for Rapid Validation and Advancement of Novel Oncology Targets” (poster presentation, first author)
• AACR, New Orleans, LA, April 2022: “Identification and optimization of novel small molecule modulators of immune checkpoint resistance with a unified representation space for genomic and chemical perturbations” (poster presentation)
• SITC, virtual meeting, November 2020: "Immunotherapy with B cell activating antibody CPI-006 in patients with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells, and memory/effector T cells" (poster presentation)
• AACR, Washington, D.C., April 2017: “A novel CD73-blocking antibody reduces production of immunosuppressive adenosine and restores T cell function” (poster presentation, second author)
• Genentech sponsored Keystone Symposia, Stromal Cells & Immunity, Keystone, CO, February, 2016: “Autophagy inhibition in mammary stroma suppresses tumorigenesis” (invited oral presentation)
• University of California, San Francisco Biomedical Sciences Graduate Program, Granlibakken, Lake Tahoe, CA, October, 2015 (mentor nominated oral presentation)
• Gordon Conference in Mammary Gland Biology, Lucca, Italy, June, 2014 (poster presentation, first author)
• Department of Defense Era of Hope Meeting, Orlando, FL, August, 2011 (poster presentation, first author)
• Keystone Symposia: Stem Cells, Cancer & Metastasis, Keystone, CO, March, 2011 (poster presentation)