Priyal Patel
Philadelphia,PA
Summary
To obtain a Bioinformatics analyst position. Highly motivated individual willing to learn and contribute knowledge of molecular biology, genomics, and computer science to investigate and manipulate complex material for biological and cellular study.
Overview
1
1
year of professional experience
Work History
Research Technician
Fox Chase Cancer Center
06.2022 - Current
- Conduct experiments and analyze data related to chronic lymphocytic leukemia (CLL) cells
- Helping to refine co-culture model for CLL that mimics lymph node microenvironment using RNA sequencing by testing different conditions
- Assessing FDA-approved drugs (monotherapy as well as combination therapy) and compounds in clinical trials for CLL/MCL patients using co-culture model
- Developed assay that can screen newly developed drugs, accelerating drug discovery process and identifying novel compounds with therapeutic potential.
Volunteer
University of Florida
- Participated in research that focuses on RNA/DNA modification pathways, enzymes and genes involved
- Worked on research project that focuses on DNA modification pathways
- Used various bioinformatics tools to extract data to successfully classify two super families of proteins that are involved in modification based on their substrate specificity and catalytic residues
- This information can be used to create exogenous DNA that can be modified to protect from degradation
Education
Master of Science - Bioinformatics
Johns Hopkins University
Baltimore, Maryland12.2023
Bachelor of Science - Biotechnology, Bioinformatics
University of Florida
Gainesville, Florida2021
Skills
- Programming Languages: R, Bash, Python, Perl
- Tools & Software: bcftools, samtools, STAR, StringTie, MACS2, RShiny, BBMap, MEME
- Suite, Phytools
- Methods & concepts: Gene set enrichment analysis (GSEA), Gene Ontology enrichment
- Analysis (ToppGene, Enrichr), Differential Gene expression analysis (DESeq2, EdgeR)
- Dimensionality reduction methods (t-SNE, PCA, hierarchical clustering), Sequence
- Assembly & Alignment (BWA/STAR/BowTie), Calling and Annotating mutations and
- Genetic aberrations (VarScan2, CNVkit, ClinVar, COSMIC), Statistical Analysis
- (Pearson/Spearman correlation, Student t-test, Wilcox rank sum test, ANOVA, Kruskal-
- Wallis)
Projects
- Using Python programming tools to implement a bioinformatics analysis pipeline that tests for the presence of protein coding adaptation in a specified gene
- Developing a central database for phages using existing databases
- Analyzing genomic data and interpretation using genomics databases, manipulating NGS data to detect genomic variations, gene expression and regulatory elements
- Analyzing publicly available expression databases (e.g., Stanford MicroArray Database GEO) by testing for outliers, filtering low-expression genes, and performing feature selection with statistical tests or ML methods to extract meaningful insights
Publications
Wu W, Lu P, Patel P, et al. SHP1 loss augments DLBCL cellular response to ibrutinib: a candidate predictive biomarker. Oncogene. 2023 Feb;42(6):409-420. doi: 10.1038/s41388-022- 02565-7. Epub 2022 Dec 8. PMID: 36482202.
Timeline
Research Technician
Fox Chase Cancer Center
06.2022 - Current
Volunteer
University of Florida
Master of Science - Bioinformatics
Johns Hopkins University
Bachelor of Science - Biotechnology, Bioinformatics
University of Florida
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