Summary
Overview
Work History
Education
Skills
Mostrecentpresentations
Invitedseminars
Honorsandawards
Membershipofprofessionalbodies
Selectedpublications
Research
Timeline
Generic

PRECIOUS ELECHI DIKE

Baltimore,US

Summary

Experienced biologist with over 5 years in cell biology and microbiology research, specializing in preclinical investigations. Proficient in both in vitro and in vivo studies, including cell proliferation assays, western blot analysis, cell culture, and qPCR. Adept at driving research that uncovers molecular targets and enhances therapeutic development. Driven Graduate Research Associate with a strong background in performing comprehensive research in various scientific fields. Possess solid skills in data analysis, project management, and report writing, contributing to successful research outcomes. Known for the ability to collaborate effectively with team members and bring innovative solutions to complex problems. Previous work has resulted in valuable contributions to academic literature and advancements in subject matter understanding.

Overview

13
13
years of professional experience

Work History

Graduate Research Associate

Morgan State University
Baltimore, US
08.2021 - 05.2025
  • Conducted preclinical in vitro and in vivo studies to explore novel therapeutic strategies for prostate cancer, with a focus on enzalutamide resistance and ferroptosis
  • Led collaborative projects to identify ferroptosis inducers and therapeutic targets for drug-resistant metastatic prostate cancer
  • Discovered novel roles of HMGA2 in regulating oxidative stress and cancer progression
  • Conducted prostate nuclei isolation for single-cell RNA sequencing, contributing to a Chan Zuckerberg Initiative (CZI) project to build a comprehensive cellular atlas of normal tissues that exhibit high cancer burden across Africa, the Caribbean, and the USA
  • Worked with in vitro and in vivo animal metastasis models to establish Epithelial Mesenchymal Transition (EMT) models in prostate cancer, and show the importance of the bone microenvironment in the induction of EMT
  • Collaborated on a Pfizer-funded project focused on identifying biomarkers for prostate cancer in Black patients, utilizing patient-derived tissues to investigate unique molecular and cellular features associated with cancer progression
  • Published peer-reviewed articles
  • Studied prostate cancer-bone microenvironment interactions in both in vivo and in vitro models
  • Mentored three undergraduate students and research interns
  • Managed laboratory operations and project workflows

Graduate Research Assistant

University of Port Harcourt
Port Harcourt, Nigeria
01.2019 - 01.2022
  • Developed a single-step method for the simultaneous production of bioethanol and alpha-amylase
  • Developed and optimized a fermentation process for improved production of weaning food with enhanced sensory and nutritional qualities
  • Conducted sensory evaluations and nutrient analyses to determine product quality and consumer acceptance
  • Analyzed experimental data using statistical software and presented findings in written reports and oral presentations

Intern

National Agency for Food and Drug Administration and Control (NAFDAC)
Port Harcourt, Nigeria
07.2012 - 01.2013
  • Assessed the microbiological and chemical quality of water, food, and drugs produced in Nigeria to ensure compliance with regulatory standards

Education

PhD - Bioenvironmental Science

Morgan State University
Baltimore, MD, US
01.2024

PhD - Microbiology

University of Port Harcourt
Port Harcourt, Nigeria
01.2022

MSc - Industrial Microbiology

University of Port Harcourt
Port Harcourt, Nigeria
01.2017

Bachelor of Technology - Microbiology Technology

University of Port Harcourt
Port Harcourt, Nigeria
01.2014

Skills

  • In vitro techniques
  • Cancer cell culture
  • Microbial cell culture
  • Cell proliferation assays
  • Migration assays
  • ELISA
  • Flow cytometry
  • Molecular techniques
  • Tumor Microenvironment characterization
  • Immune cell infiltration
  • Stromal interactions
  • Signaling pathways
  • RNA-Seq Analysis Preparation
  • Gene expression analysis
  • Protein expression analysis
  • PCR
  • QPCR
  • Western blotting
  • Transfection
  • DNA extraction
  • RNA extraction
  • In vivo techniques
  • Intrafemoral injections
  • Intraperitoneal injections
  • Subcutaneous injections
  • Sperm collection
  • Stereotaxic surgery
  • Project management
  • Collaboration
  • Project planning
  • Experimental protocol troubleshooting
  • Data analysis
  • Statistical analysis
  • GraphPad Prism
  • Collaboration & communication
  • Research presentation
  • Scientific report writing
  • Literature review
  • Critical thinking

Mostrecentpresentations

  • The Jackson Laboratory 33rd Annual Short Course on Experimental Models of Human Cancer, 08/04/24, Bar Harbor, ME
  • Research Centers in Minority institutions (RCMI) Consortium National Conference, 04/29/24 - 05/01/24, Hyatt Regency Bethesda, MD
  • 16TH American Association for Cancer Research (AACR) conference on the science of cancer health disparities, 09/29/23 - 10/02/23, Disney’s Grand Floridian Resort, Orlando, Florida
  • Research Centers in Minority institutions (RCMI) Consortium National Conference, 04/12/23 - 04/14/23, Bethesda Marriott Hotel, Bethesda, MD

Invitedseminars

  • The Jackson Laboratory 33rd Annual Short Course on Experimental Models of Human Cancer, 08/04/24, Bar Harbor, ME
  • 16TH American Association for Cancer Research (AACR) conference on the science of cancer health disparities, 09/29/23 - 10/02/23, Disney’s Grand Floridian Resort, Orlando, Florida

Honorsandawards

  • TETFUND travel grant award for training of Laboratory Technologist and Technicians by Association of University institute of Technology ADIUT, France 2021.
  • World Bank Africa Centre for Excellence ACE-CEFOR Research Grant award and PhD scholarship.
  • Indian Research and Training Fellowship for Developing Country Scientists (RTF-DCS) scheme award for 6 months study period 2019.
  • Overall Best Graduating Student in School of Science Laboratory, University of Port Harcourt (2012-2013 academic session award).
  • Best Graduating Student in Microbiology Technology, University of Port Harcourt (2012-2013 academic session award).
  • Best Graduating Female Student, University of Port Harcourt (2012-2013 academic session award).
  • Best Graduating Student in Industrial Safety, University of Port Harcourt (2012-2013 academic session award).
  • Best Research Project in School of science Laboratory Technology (2012-2013 academic session award).

Membershipofprofessionalbodies

  • American Association for Cancer Research (Associate member)
  • American Society of Microbiology (Global ambassador)
  • Nigerian Society for Microbiology (PG student)

Selectedpublications

  • Dike, P.E, Bor-Jang H. Campbell, T., Awoolowo M., Elliott, B., & Odero-Marah, V. (2024). HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells. Biochemical and Biophysical Research Communications, 150859.
  • Liadi, Y., Campbell, T., Dike, P., Harlemon, M., Elliott, B., & Odero-Marah, V. (2023). Prostate cancer metastasis and health disparities: a systematic review. Prostate Cancer and Prostatic Diseases, 1-9.
  • Campbell, T., Hawsawi, O., Henderson, V., Dike P., Hwang, B. J., Liadi, Y., White, E. Z., Zou J, Wang G, Zhang Q, Bowen N, Scott D, Hinton C. and Odero-Marah, V. Novel Roles for Hmga2 Isoforms in Regulating Oxidative Stress and Sensitizing to RSL3-Induced Ferroptosis in Prostate Cancer Cells. Heliyon, 9(4), 2405-8440.

Research

  • Graduate Research Associate, Morgan State University, Baltimore, MD, 08/01/21, 05/01/25, Dr. Valerie Odero-Marah, Conducted preclinical in vitro and in vivo studies to explore novel therapeutic strategies for prostate cancer., Led collaborative projects to identify ferroptosis inducers and therapeutic targets for drug-resistant metastatic prostate cancer., Discovered novel roles of HMGA2 in regulating oxidative stress and cancer progression., Conducted prostate nuclei isolation for single-cell RNA sequencing., Worked with in vitro and in vivo animal metastasis models., Collaborated on a Pfizer-funded project focused on identifying biomarkers for prostate cancer in Black patients., Published peer-reviewed articles., Mentored three undergraduate students and research interns., Managed laboratory operations and project workflows.
  • Graduate Research Assistant, University of Port Harcourt, Port Harcourt, Nigeria, 08/01/19, 05/01/22, Dr. Chimezie Jason Ogugbue, Developed a single-step method for the simultaneous production of bioethanol and alpha-amylase., Developed and optimized a fermentation process for improved production of weaning food., Conducted sensory evaluations and nutrient analyses., Analyzed experimental data using statistical software.
  • Intern, National Agency for Food and Drug Administration and Control (NAFDAC), Port Harcourt, Nigeria, 07/01/12, 01/01/13, Assessed the microbiological and chemical quality of water, food, and drugs.

Timeline

Graduate Research Associate

Morgan State University
08.2021 - 05.2025

Graduate Research Assistant

University of Port Harcourt
01.2019 - 01.2022

Intern

National Agency for Food and Drug Administration and Control (NAFDAC)
07.2012 - 01.2013

PhD - Bioenvironmental Science

Morgan State University

PhD - Microbiology

University of Port Harcourt

MSc - Industrial Microbiology

University of Port Harcourt

Bachelor of Technology - Microbiology Technology

University of Port Harcourt
PRECIOUS ELECHI DIKE